{"id":12192,"date":"2021-01-27T10:46:16","date_gmt":"2021-01-27T12:46:16","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12192"},"modified":"2023-01-05T14:40:18","modified_gmt":"2023-01-05T17:40:18","slug":"cannabis-and-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/canabisul-si-boala-alzheimer\/","title":{"rendered":"Ce se \u0219tie despre canabis \u0219i boala Alzheimer"},"content":{"rendered":"
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Boala Alzheimer (AD) este o boal\u0103 neurodegenerativ\u0103 responsabil\u0103 pentru mai mult de 50% din cazurile de demen\u021b\u0103 diagnosticate \u00een prezent \u0219i este direct corelat\u0103 cu \u00eemb\u0103tr\u00e2nirea. \u00cen prezent, 40% dintre persoanele cu v\u00e2rsta de peste 85 de ani au un anumit nivel de demen\u021b\u0103.<\/p>\n\n\n\n

Anterior, se credea c\u0103 simptomele bolii Alzheimer erau legate doar de un declin al func\u021biilor cognitive care afectau memoria pe termen scurt, \u00een timp ce \u00een stadii avansate ale bolii afecteaz\u0103 abilit\u0103\u021bile lingvistice ale pacien\u021bilor \u0219i chiar memoria pe termen lung.<\/p>\n\n\n\n

Cu toate acestea, ast\u0103zi se \u0219tie c\u0103 pacien\u021bii care sufer\u0103 de DA prezint\u0103 o serie de alte simptome, cum ar fi depresia, psihoza, comportamente agresive, ceea ce agraveaz\u0103 \u0219i mai mult boala. <\/p>\n\n\n\n

\u00cen ultimii ani, cercet\u0103torii \u0219i medicii au raportat \u00een studiile lor rezultate pozitive atunci c\u00e2nd au \u00eenceput s\u0103 \u00ee\u0219i trateze pacien\u021bii cu AD cu medicamente pe baz\u0103 de canabis, ob\u021bin\u00e2nd ameliorarea simptomelor.<\/p>\n\n\n\n

Sistemul endocannabinoid a devenit o abordare alternativ\u0103 pentru tratamentul diferitelor boli \u0219i patologii, \u00een afar\u0103 de influen\u021ba sa \u00een mai multe procese, cum ar fi neuroplasticitatea, neuroinflamarea, tulbur\u0103rile de comportament, reglarea somnului, func\u021biile imunologice, bolile inflamatorii, func\u021biile cardiovasculare, durerea, controlul motor, echilibrul energetic \u0219i apetitul. <\/p>\n\n\n\n

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Fotografie realizat\u0103 de Ravi Patel<\/a> pe Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Din p\u0103cate, exist\u0103 \u00eenc\u0103 pu\u021bine studii oficiale care s\u0103 analizeze \u00een mod direct rela\u021bia dintre sistemul endocannabinoid \u0219i DA.<\/p>\n\n\n\n

\u00cen prezent, este bine cunoscut faptul c\u0103 DA este cauzat\u0103 de factori genetici \u0219i de \u00eemb\u0103tr\u00e2nire. Principalii vinova\u021bi de aceast\u0103 boal\u0103 sunt atribui\u021bi la pl\u0103ci senile<\/strong> \u0219i \u00eencurcate neurofibrilare<\/strong>. <\/p>\n\n\n\n

Un fapt interesant este c\u0103, folosind modele de \u0219obolani cu AD, cercet\u0103torii au descoperit c\u0103 creierul bolnav de AD are un num\u0103r mai mic de receptori CB1 \u00een compara\u021bie cu creierul s\u0103n\u0103tos - un num\u0103r mai mic de receptori CB1 ar putea, \u00een cele din urm\u0103, s\u0103 diminueze efectul terapeutic al medicamentului.<\/p>\n\n\n\n

Tratamentul cu canabinoizi poate produce un efect protector \u00eempotriva stresului oxidativ \u0219i a neuroinflam\u0103rii \u00een creierul pacien\u021bilor cu boala Alzheimer, contribuind la reducerea form\u0103rii pl\u0103cilor amiloide \u0219i a \u00eencurc\u0103turilor neurofibrilare - \u00eent\u00e2rziind declinul cognitiv al pacien\u021bilor. <\/p>\n\n\n\n

De\u0219i pl\u0103cile amiloide pot fi g\u0103site \u0219i \u00een creierele s\u0103n\u0103toase, frecven\u021ba lor este extrem de sc\u0103zut\u0103 \u00een compara\u021bie cu creierele cu Alzheimer.<\/p>\n\n\n\n

Studiile dedicate \u00een\u021belegerii motivelor pentru care canabinoizii au un efect terapeutic asupra pacien\u021bilor cu AD au descoperit c\u0103 molecula de THC are capacitatea de a cre\u0219te biodisponibilitatea unui neurotransmi\u021b\u0103tor numit acetilcolin\u0103<\/strong> (Ach) prin inhibarea enzimei de degradare a acestuia acetilcolinesteraz\u0103<\/strong> (AChE) - Ach este \u00een esen\u021b\u0103 responsabil pentru redirec\u021bionarea impulsului nervos c\u0103tre urm\u0103torul neuron. <\/p>\n\n\n\n

\u00centr-un creier s\u0103n\u0103tos, enzima AChE are rolul de a descompune Ach, \u00eens\u0103, \u00eentr-un creier cu boala Alzheimer, enzima este foarte prezent\u0103, degrad\u00e2nd mult mai mult Ach dec\u00e2t ar trebui s\u0103 o fac\u0103, ceea ce provoac\u0103 un declin al func\u021biei cognitive a creierului \u00een timp.   <\/p>\n\n\n\n

Cercet\u0103torii au raportat c\u0103 canabinoizii pot fi de ajutor datorit\u0103 ac\u021biunii sale inhibitoare a enzimei AChE - a demonstrat r\u0103spunsuri mai bune dec\u00e2t alte medicamente disponibile \u00een comer\u021b. <\/p>\n\n\n\n

De asemenea, THC poate contribui la reducerea tulbur\u0103rilor de comportament \u0219i regleaz\u0103 ciclul circadian al pacien\u021bilor cu demen\u021b\u0103 sever\u0103. Unii oameni de \u0219tiin\u021b\u0103 afirm\u0103 chiar c\u0103 canabinoizii THC \u0219i CBD au poten\u021bialul de a fi terapii anti-Alzheimer.<\/p>\n\n\n\n

Un articol publicat \u00een 2015 \u00een revista Clinical Pharmacology and Therapeutics<\/a>, ofer\u0103 o imagine de ansamblu a poten\u021bialului canabinoizilor \u00een tratamentul bolii Alzheimer cu debut tardiv \u0219i a simptomelor neuropsihice asociate la persoanele \u00een v\u00e2rst\u0103, discut\u00e2nd, de asemenea, aspecte ale medicamentelor pe baz\u0103 de canabis \u00een ceea ce prive\u0219te eficacitatea, siguran\u021ba \u0219i farmacocinetica.<\/p>\n\n\n\n

Un b\u0103rbat \u00een v\u00e2rst\u0103 de 72 de ani cu boala Alzheimer avea o tulburare de comportament de tip agita\u021bie \u0219i agresivitate. Tratamentul s\u0103u anterior nu a ar\u0103tat nicio \u00eembun\u0103t\u0103\u021bire semnificativ\u0103. <\/p>\n\n\n\n

Atunci c\u00e2nd pacientului i s-a introdus Nabilone - un medicament sintetic cu THC - acesta a demonstrat \u00een scurt timp o ameliorare a tulbur\u0103rilor de comportament \u0219i a altor simptome, \u00een plus, nu a avut efecte adverse \u00een timpul tratamentului cu medicamentul pe baz\u0103 de THC.<\/p>\n\n\n\n

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Fotografie realizat\u0103 de Louis Reed<\/a> pe Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Un alt grup de studiu format din cincisprezece pacien\u021bi cu boala Alzheimer - cu v\u00e2rsta medie de 72 de ani - a prezentat \u00eenainte de tratament tulbur\u0103ri de comportament \u0219i probleme de alimenta\u021bie. <\/p>\n\n\n\n

Cei cincisprezece pacien\u021bi au fost trata\u021bi timp de \u0219ase s\u0103pt\u0103m\u00e2ni cu dronabinol - cunoscut \u0219i sub numele de Marinol - un medicament sintetic cu THC. <\/p>\n\n\n\n

Ace\u0219tia au prezentat dup\u0103 o perioad\u0103 de tratament o \u00eembun\u0103t\u0103\u021bire a comportamentului, o cre\u0219tere \u00een greutate \u0219i o sc\u0103dere a agita\u021biei - \u00een compara\u021bie cu placebo. Au fost observate unele efecte adverse, cum ar fi oboseala, somnolen\u021ba \u0219i euforia, toate au confirmat c\u0103 sunt asociate cu dronabinolul.<\/p>\n\n\n\n

Un alt grup de \u0219ase pacien\u021bi, cu v\u00e2rsta medie de 81 de ani, unii cu AD \u0219i al\u021bii suferind de demen\u021b\u0103 sever\u0103, au \u00eenceput un tratament de dou\u0103 s\u0103pt\u0103m\u00e2ni cu dronabinol. <\/p>\n\n\n\n

Rezultatele au ar\u0103tat o \u00eembun\u0103t\u0103\u021bire semnificativ\u0103 a activit\u0103\u021bilor motorii nocturne ale acestor pacien\u021bi \u0219i un comportament mai bun. \u00cen acest grup, nu s-au observat efecte adverse.<\/p>\n\n\n\n

\u00centr-un alt studiu, un grup de 40 de pacien\u021bi cu diferite niveluri de demen\u021b\u0103 \u0219i 13 dintre ei cu boala Alzheimer. <\/p>\n\n\n\n

To\u021bi au fost introdu\u0219i \u00een tratamentul cu dronabinol pentru a trata problemele de comportament \u0219i tulbur\u0103rile de apetit. <\/p>\n\n\n\n

Perioada de tratament a fost de 17 zile, iar pacien\u021bii s-au \u00eembun\u0103t\u0103\u021bit din ambele puncte de vedere. Au fost raportate efecte adverse precum sedare, delir, infec\u021bii ale tractului urinar \u0219i confuzie, dar, potrivit cercet\u0103torilor, acestea nu au fost direct asociate cu utilizarea dronabinolului.<\/p>\n\n\n\n

\u00cen ciuda mai multor studii, ale c\u0103ror rezultate arat\u0103 rezultate pozitive \u00een utilizarea canabinoizilor \u00een tratamentul pacien\u021bilor cu demen\u021b\u0103, unii cercet\u0103tori sus\u021bin c\u0103 nu exist\u0103 \u00eenc\u0103 suficiente dovezi care s\u0103 demonstreze c\u0103 canabinoizii sunt cu adev\u0103rat buni \u0219i siguri \u00een tratarea tulbur\u0103rilor de comportament \u0219i a demen\u021bei.<\/p>\n\n\n\n

\u00cen orice caz, cercet\u0103torii au raportat din ce \u00een ce mai des utilizarea medicamentelor pe baz\u0103 de canabis pentru tratarea pacien\u021bilor cu AD, \u0219i nu numai, ci \u0219i \u00een tratamentul bolii Parkinson \u0219i al autismului, medicii \u0219i oamenii de \u0219tiin\u021b\u0103 raport\u00e2nd \u00eembun\u0103t\u0103\u021birea calit\u0103\u021bii vie\u021bii pacien\u021bilor lor dup\u0103 ce au \u00eenceput s\u0103 ia medicamente pe baz\u0103 de canabis. Dar, acesta este un subiect pentru urm\u0103torul articol.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Sunte\u021bi din domeniul neurologiei? \u00cen Mind the Graph exist\u0103 o categorie mare de ilustra\u021bii din domeniul neurologiei, unde pute\u021bi g\u0103si tot ce ave\u021bi nevoie pentru lucrarea sau prezentarea dumneavoastr\u0103 din domeniul neurologiei. Consulta\u021bi aici<\/a>.  <\/strong><\/p>\n\n\n\n

Sau <\/strong>pe care \u00eel c\u0103uta\u021bi biochimie <\/a>\u0219i biologie molecular\u0103<\/a> ilustra\u021bii pe care le pute\u021bi g\u0103si \u0219i \u00een Mind the Graph. <\/p>\n\n\n\n

\u0218i suntem aici pentru a v\u0103 ajuta dac\u0103 ave\u021bi nevoie de orice altceva, doar autentifica\u021bi-v\u0103 \u00een contul dvs.<\/a> \u0219i trimite\u021bi-ne un mesaj \u00een sec\u021biunea SOLICITA\u021aI O PICTOGRAM\u0102<\/strong>. <\/p>\n\n\n\n

Referin\u021be<\/strong><\/p>\n\n\n\n

AHMED, A. I. A. A. et al. Canabinoizi \u00een boala Alzheimer cu debut tardiv. Farmacologie clinic\u0103 & Terapeutic\u0103<\/strong>, v. 97, n. 6, p. 597-606, 2015.<\/p>\n\n\n\n

AHMED, A. I. A. A. et al. Canabinoizi \u00een boala Alzheimer cu debut tardiv. Farmacologie clinic\u0103 & Terapeutic\u0103<\/strong>, v. 97, n. 6, p. 597-606, 2015.<\/p>\n\n\n\n

BALASH, Y. et al. Canabisul medical \u00een boala Parkinson: Experien\u021ba pacien\u021bilor din via\u021ba real\u0103. Neurofarmacologie clinic\u0103<\/strong>, v. 40, n. 6, p. 268-272, dez. 2017.<\/p>\n\n\n\n

BENITO, C. et al. The Endocannabinoid System and Alzheimer's Disease. Neurobiologie molecular\u0103<\/strong>, v. 36, n. 1, p. 75-81, 1 ago. 2007.<\/p>\n\n\n\n

DE FARIA, S. M. et al. Efectele administr\u0103rii acute de canabidiol asupra anxiet\u0103\u021bii \u0219i tremur\u0103turilor induse de un test simulat de vorbire \u00een public la pacien\u021bii cu boala Parkinson. Jurnalul de psihofarmacologie<\/strong>, v. 34, nr. 2, p. 189-196, 1 feb. 2020.<\/p>\n\n\n\n

FALCO, A. D. et al. DOEN\u00c7A DE ALZHEIMER: HIP\u00d3TESES ETIOL\u00d3GICAS E PERSPECTIVAS DE TRATAMENTO. Chimie nou\u0103<\/strong>, v. 39, n. 1, p. 63-80, ian. 2016.<\/p>\n\n\n\n

LEEHEY, M. A. et al. Siguran\u021ba \u0219i tolerabilitatea canabidiolului \u00een boala Parkinson: An Open Label, Dose-Escalation Study. Cercetare \u00een domeniul canabisului \u0219i al canabinoizilor<\/strong>, 19 mar. 2020.<\/p>\n\n\n\n

POLEG, S. et al. Cannabidiolul ca un candidat propus pentru tratamentul tulbur\u0103rilor din spectrul autist. Progrese \u00een neuropsihofarmacologie \u0219i psihiatrie biologic\u0103<\/strong>, v. 89, p. 90-96, 8 mar. 2019.YOO, K.-Y.; PARK, S.-Y. Terpenoidele ca poten\u021biale terapeutice anti-Alzheimer's Disease. Molecule<\/strong>, v. 17, n. 3, p. 3524-3538, mar. 2012.<\/p>","protected":false},"excerpt":{"rendered":"

Boala Alzheimer (AD) este o boal\u0103 neurodegenerativ\u0103 responsabil\u0103 pentru mai mult de 50% din cazurile de demen\u021b\u0103 diagnosticate \u00een prezent \u0219i este direct corelat\u0103 cu \u00eemb\u0103tr\u00e2nirea. \u00cen prezent, 40% dintre persoanele cu v\u00e2rsta de peste 85 de ani au un anumit nivel de demen\u021b\u0103. Anterior se credea c\u0103 simptomele bolii Alzheimer erau legate doar de un declin al func\u021biei cognitive care afecta memoria pe termen scurt, \u00een timp ce \u00een [...]<\/p>","protected":false},"author":4,"featured_media":12193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959],"tags":[213,819,554],"yoast_head":"\nWhat is Out There About Cannabis and Alzheimer\u2019s Disease - MTG<\/title>\n<meta name=\"description\" content=\"Do you know Cannabis and Alzheimer's Disease can be related? 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