{"id":12121,"date":"2021-01-11T11:05:53","date_gmt":"2021-01-11T13:05:53","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12121"},"modified":"2023-01-05T14:52:03","modified_gmt":"2023-01-05T17:52:03","slug":"cause-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/","title":{"rendered":"O nou\u0103 teorie \u00eencearc\u0103 s\u0103 explice cauza bolii Alzheimer"},"content":{"rendered":"

Mai mult de jum\u0103tate din cazurile de demen\u021b\u0103 din zilele noastre sunt clasificate ca fiind boala Alzheimer - o boal\u0103 neurodegenerativ\u0103 cronic\u0103 care afecteaz\u0103 treptat cogni\u021bia \u0219i memoria unei persoane. <\/p>\n\n\n\n

P\u00e2n\u0103 \u00een prezent, se credea c\u0103 este cauzat\u0103 de factori genetici \u0219i de \u00eemb\u0103tr\u00e2nire, r\u0103uf\u0103c\u0103torii \u0219i principalii vinova\u021bi ai bolii fiind atribui\u021bi pl\u0103cilor senile \u0219i \u00eencurc\u0103turilor neurofibrilare, care duc la neuroinflamare \u0219i, \u00een consecin\u021b\u0103, la moartea neuronilor. <\/p>\n\n\n\n

Cu toate acestea, o nou\u0103 teorie a cauzelor bolii Alzheimer arunc\u0103 o lumin\u0103 pe cerul cercet\u0103rii medicale. <\/p>\n\n\n\n

Teoria este c\u0103 genetica \u0219i \u00eemb\u0103tr\u00e2nirea nu sunt singurii factori responsabili pentru formarea aglomer\u0103rilor de amiloid - proteina care se acumuleaz\u0103 \u00eentre neuroni cauz\u00e2nd boala Alzheimer - ci poate fi \u0219i un r\u0103spuns declan\u0219ator la o infec\u021bie microbian\u0103.  <\/p>\n\n\n\n

S\u0103 arunc\u0103m o privire mai atent\u0103 la o scal\u0103 neurologic\u0103 pentru a \u00een\u021belege imaginea de ansamblu a ceea ce se \u00eent\u00e2mpl\u0103 \u00een interiorul unui creier afectat de boala Alzheimer. Se \u00eent\u00e2mpl\u0103 dou\u0103 fenomene majore.<\/p>\n\n\n\n

O protein\u0103 numit\u0103 tau este responsabil\u0103 pentru men\u021binerea stabilit\u0103\u021bii prin sus\u021binerea microtubulilor din interiorul neuronilor. \u00centr-un creier care sufer\u0103 de aceast\u0103 afec\u021biune, tau este modificat\u0103 biochimic printr-o reac\u021bie numit\u0103 reac\u021bie de hiperfosforilare. <\/p>\n\n\n\n

Rezultatul acestei modific\u0103ri este reprezentat de buc\u0103\u021bi de proteine insolubile \u00een interiorul neuronului, care distrug \u00eentregul sistem \u0219i ucid celulele neuronale. <\/p>\n\n\n\n

Aceste buc\u0103\u021bi insolubile de proteine tau se agreg\u0103 unele la altele form\u00e2nd \u00eencurc\u0103turile neurofibrilare.<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

The pl\u0103ci senile<\/strong> sunt f\u0103cute din peptide amiloid-\u03b2<\/strong>. O protein\u0103 prezent\u0103 \u00een membranele neuronilor (pre-amiloid) sufer\u0103 un proces de clivaj care are ca rezultat buc\u0103\u021bi libere de amiloid-\u03b2 \u00een afara neuronilor*. <\/p>\n\n\n\n

Aceste buc\u0103\u021bi ar trebui s\u0103 fie cur\u0103\u021bate din mediul neuronal extern de celule \u0219i enzime speciale prin fagocitoz\u0103, dar din cauza unor factori genetici sau de \u00eemb\u0103tr\u00e2nire, acest proces nu se desf\u0103\u0219oar\u0103 suficient de eficient, ceea ce duce la buc\u0103\u021bi libere de proteine amiloide-\u03b2 insolubile care \u00eencep s\u0103 se agregheze \u00een pl\u0103ci.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Pl\u0103cile amiloide sunt cele mai studiate \u0219i discutate ca fiind cauza bolii Alzheimer. Dar oamenii de \u0219tiin\u021b\u0103 afirm\u0103, de asemenea, c\u0103 \u00eencurc\u0103turile neurofibrilare sunt direct asociate cu evolu\u021bia bolii.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Oamenii de \u0219tiin\u021b\u0103 au g\u0103sit, de asemenea, aglomer\u0103ri amiloide \u00een creierele s\u0103n\u0103toase post-mortem. Ceea ce \u00eenseamn\u0103 c\u0103 \u0219i \u00eentr-un creier s\u0103n\u0103tos \u0219i b\u0103tr\u00e2n procesul de cur\u0103\u021bare devine mai pu\u021bin eficient, dar nu at\u00e2t de mult ca \u00eentr-un creier cu boala Alzheimer.<\/p>\n\n\n\n

Prin urmare, un num\u0103r mare de aceste pl\u0103ci senile \u0219i \u00eencurc\u0103turi neurofibrilare caracterizeaz\u0103 boala Alzheimer; ele devin extrem de toxice pentru creier \u0219i modific\u0103 eficien\u021ba \u0219i calitatea sinapselor. <\/p>\n\n\n\n

Subiec\u021bii afecta\u021bi prezint\u0103 simptome precum pierderea memoriei, confuzie legat\u0103 de timp \u0219i loca\u021bie, depresie, anxietate, probleme de limbaj \u0219i comunicare, instabilitate a dispozi\u021biei \u0219i altele.<\/p>\n\n\n\n

\u00cen noua teorie propus\u0103<\/strong>, pl\u0103cile amiloide sunt un mecanism de protec\u021bie a creierului \u00eempotriva infec\u021biei microbilor. <\/p>\n\n\n\n

Gena amiloid-\u03b2 este prezent\u0103 \u00eentr-o mare parte a grupului de vertebrate \u0219i s-a p\u0103strat la diferite specii timp de mai multe genera\u021bii, ceea ce \u00eenseamn\u0103 c\u0103 ar trebui s\u0103 aib\u0103 un rol util \u0219i important pentru organismul nostru, nu doar s\u0103 ac\u021bioneze ca ceva d\u0103un\u0103tor - dac\u0103 nu ar fi fost ceva valabil sau benefic, gena ar fi disp\u0103rut de mult timp pe calea evolu\u021biei.<\/p>\n\n\n\n

Oamenii de \u0219tiin\u021b\u0103 au c\u0103utat mii de creiere post-mortem de la persoane cu boala Alzheimer. <\/p>\n\n\n\n

De\u0219i s-au confruntat cu dificult\u0103\u021bi \u00een analiza acestor tipuri de creier din cauza condi\u021biilor proaste, au reu\u0219it s\u0103 studieze \u0219i s\u0103 colecteze informa\u021bii pentru a propune ulterior c\u00e2teva posibile cauze declan\u0219atoare ale microbilor. <\/p>\n\n\n\n

Ace\u0219ti declan\u0219atori sunt mecanisme de ap\u0103rare \u00eempotriva unor tipuri de virusuri herpetice umane, cum ar fi herpesvirusul 1, 6A \u0219i 7, \u0219i a trei bacterii, Pneumonie cu Chlamydia<\/em>, Borrelia burgdorferi<\/em>, Porphyromonas gingivalis<\/em>.<\/p>\n\n\n\n

Teoria este c\u0103 beta-amiloidul are ini\u021bial o func\u021bie defensiv\u0103, prinz\u00e2nd microbii care se \u00eendreapt\u0103 spre creier, oprind o posibil\u0103 infec\u021bie sau boal\u0103. <\/p>\n\n\n\n

A\u0219a cum am men\u021bionat, din cauza factorilor de \u00eemb\u0103tr\u00e2nire, creierul \u00ee\u0219i pierde capacitatea de a cur\u0103\u021ba eficient amiloizii. Astfel, este posibil ca ideea func\u021biei amiloidului s\u0103 fie gre\u0219it\u0103 de la bun \u00eenceput; acesta este probabil implicat \u00eentr-un tip de protec\u021bie antimicrobian\u0103 \u00eempotriva invadatorilor din creier, fiind clasificat ca peptid\u0103 antimicrobian\u0103.<\/p>\n\n\n\n

Oamenii de \u0219tiin\u021b\u0103 au ob\u021binut rezultate pozitive \u00eencerc\u00e2nd s\u0103 demonstreze c\u0103 \u03b2-amiloidul ar putea ucide microorganismele din c\u00e2teva boli comune. <\/p>\n\n\n\n

\u00cen plus, un alt studiu care a \u00eenceput \u00een 2007 \u0219i ar trebui s\u0103 se \u00eencheie \u00een 2022 la Universitatea Columbia din New York testeaz\u0103 un medicament antiviral la pacien\u021bii cu h<\/s>erpes simplex virus 1 \u0219i boala Alzheimer u\u0219oar\u0103, pentru a vedea dac\u0103 medicamentul poate \u00eencetini evolu\u021bia bolii. <\/p>\n\n\n\n

Deocamdat\u0103, singurul lucru pe care \u00eel putem face este s\u0103 sper\u0103m c\u0103 va fi bine \u0219i s\u0103 a\u0219tept\u0103m rezultatele.<\/p>\n\n\n\n

Aceast\u0103 nou\u0103 teorie propus\u0103 nu este \u00eenc\u0103 bine acceptat\u0103 de \u00eentreaga comunitate \u0219tiin\u021bific\u0103. Mul\u021bi oameni de \u0219tiin\u021b\u0103 sus\u021bin c\u0103, chiar dac\u0103 aceast\u0103 nou\u0103 teorie propus\u0103 va fi dovedit\u0103, factorii genetici \u0219i muta\u021biile nefaste vor fi \u00een continuare cauza principal\u0103 a bolii. <\/p>\n\n\n\n

Boala Alzheimer este \u00eenc\u0103 o afec\u021biune despre care se cunosc foarte pu\u021bine cuno\u0219tin\u021be \u0219tiin\u021bifice cu privire la cauzele sale reale; nu exist\u0103 niciun tratament curativ \u0219i nici prea multe op\u021biuni terapeutice. Dac\u0103 aceast\u0103 teorie se dovede\u0219te a fi adev\u0103rat\u0103, ar putea fi primul pas \u00een direc\u021bia unor tratamente mai bune. Hai, \u0219tiin\u021b\u0103!<\/p>\n\n\n\n

Referin\u021be<\/strong><\/p>\n\n\n\n

ABBOTT, A. Sunt infec\u021biile la originea unor cazuri de Alzheimer? Natura<\/strong>, v. 587, n. 7832, p. 22-25, 4 nov. 2020.<\/p>\n\n\n\n

CEC\u00cd, K. et al. Biomarkeri \u00een boala Alzheimer. Geriatrie, gerontologie \u0219i \u00eemb\u0103tr\u00e2nire<\/strong>, v. 6, nr. 3, p. 273-282, 2012.<\/p>\n\n\n\n

MAKIN, S. Ipoteza amiloidian\u0103 \u00een proces. Natura<\/strong>, v. 559, n. 7715, p. S4-S7, 25 iul. 2018.<\/p>\n\n\n\n

YOO, K.-Y.; PARK, S.-Y. Terpenoidele ca poten\u021biale terapeutice anti-Alzheimer's Disease. Molecule<\/strong>, v. 17, n. 3, p. 3524-3538, mar. 2012.<\/p>\n\n\n\n

___
Dac\u0103 ave\u021bi nevoie s\u0103 crea\u021bi un infografic \u00een scopuri \u0219tiin\u021bifice - ca mine - \u00een Mind the Graph pute\u021bi crea orice tip de infografic de care ave\u021bi nevoie \u0219i pe care \u00eel dori\u021bi. Platforma este aici pentru a transforma oamenii de \u0219tiin\u021b\u0103 \u00een designeri pentru a le cre\u0219te impactul! Al\u0103tura\u021bi-v\u0103 nou\u0103 pe platform\u0103, click aici<\/a>!<\/p>","protected":false},"excerpt":{"rendered":"

Mai mult de jum\u0103tate din cazurile de demen\u021b\u0103 din zilele noastre sunt clasificate ca fiind boala Alzheimer - o boal\u0103 neurodegenerativ\u0103 cronic\u0103 care afecteaz\u0103 treptat cogni\u021bia \u0219i memoria unei persoane. P\u00e2n\u0103 \u00een prezent se credea c\u0103 este cauzat\u0103 de factori genetici \u0219i de \u00eemb\u0103tr\u00e2nire, r\u0103uf\u0103c\u0103torii \u0219i principalii vinova\u021bi ai bolii sunt atribui\u021bi [...]<\/p>","protected":false},"author":4,"featured_media":12125,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[213,554,964,136],"yoast_head":"\nNew Theory Tries to Explain The Cause of Alzheimer\u2019s<\/title>\n<meta name=\"description\" content=\"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Theory Tries to Explain The Cause of Alzheimer\u2019s\" \/>\n<meta property=\"og:description\" content=\"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-11T13:05:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-05T17:52:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/new-theory-tries-to-explain-the-cause-of-alzheimers-disease.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1110\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New Theory Tries to Explain The Cause of Alzheimer\u2019s","description":"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/","og_locale":"ro_RO","og_type":"article","og_title":"New Theory Tries to Explain The Cause of Alzheimer\u2019s","og_description":"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.","og_url":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/","og_site_name":"Mind the Graph Blog","article_published_time":"2021-01-11T13:05:53+00:00","article_modified_time":"2023-01-05T17:52:03+00:00","og_image":[{"width":1110,"height":600,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/new-theory-tries-to-explain-the-cause-of-alzheimers-disease.png","type":"image\/png"}],"author":"Fabricio Pamplona","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabricio Pamplona","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/","url":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/","name":"New Theory Tries to Explain The Cause of Alzheimer\u2019s","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2021-01-11T13:05:53+00:00","dateModified":"2023-01-05T17:52:03+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3"},"description":"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/#breadcrumb"},"inLanguage":"ro-RO","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"New Theory Tries to Explain The Cause of Alzheimer\u2019s Disease"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"ro-RO"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3","name":"Fabricio Pamplona","image":{"@type":"ImageObject","inLanguage":"ro-RO","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","caption":"Fabricio Pamplona"},"description":"Fabricio Pamplona is the founder of Mind the Graph - a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/ro\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts\/12121"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/comments?post=12121"}],"version-history":[{"count":3,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts\/12121\/revisions"}],"predecessor-version":[{"id":26048,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts\/12121\/revisions\/26048"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/media\/12125"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/media?parent=12121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/categories?post=12121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/tags?post=12121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}