{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/coronavirus-covid-19-este-hidroxiclorochina-noul-speranta-aparent-da\/","title":{"rendered":"Coronavirus (Covid-19): este hidroxiclorochina noua speran\u021b\u0103? Aparent, da."},"content":{"rendered":"

Dou\u0103 lucr\u0103ri recente au sintetizat o cercetare in vitro \u0219i un studiu clinic la scar\u0103 mic\u0103 a fost suficient pentru ca Donald Trump s\u0103 determine FDA s\u0103 aplice o nou\u0103 indica\u021bie clinic\u0103 pentru hidroxiclorochina: \u00eembun\u0103t\u0103\u021birea simptomelor pacien\u021bilor afecta\u021bi de Coronavirus (Covid-19).<\/p>\n

Acesta este probabil cel mai rapid proces de aprobare a unui medicament din istoria modern\u0103 \u0219i se pare c\u0103 pre\u0219edintele are dreptate. Surprinz\u0103tor pentru un lider global care nu are prea mult\u0103 afec\u021biune pentru \u0219tiin\u021b\u0103.<\/p>\n

\"\"<\/p>\n

Primele dovezi despre efectul hidroxiclorochina asupra virusului au venit de la aceast\u0103 lucrare publicat\u0103 ieri pe Cell Discovery<\/a>Este vorba doar de un studiu in vitro, cu toate limit\u0103rile aferente, dar care arat\u0103 clar poten\u021bialul medicamentului de a distruge virusul. \u00cen momentul \u00een care au prezentat lucrarea, 80.000 de cazuri au fost confirmate \u00een China, inclusiv 2946 de decese, precum \u0219i peste 10.566 de cazuri confirmate \u00een alte 72 de \u021b\u0103ri. La acel moment, cea mai mare speran\u021b\u0103 era depus\u0103 \u00eentr-un medicament numit remdesivir.<\/p>\n

\"efectele
Efectele in vitro ale hidroclorocainelor asupra coronavirusului (Covid-19). Coloana din dreapta arat\u0103 efectele medicamentului eficient, spre deosebire de clorochin\u0103 sau de grupul de control din st\u00e2nga. Aceasta arat\u0103 c\u0103 medicamentul a \u00eembun\u0103t\u0103\u021bit capacitatea celulelor de a extr\u0103da viru\u0219ii... este ca \u0219i cum ai ajuta la alungarea unui vecin nedorit din casa ta. Ajut\u0103! \ud83d\ude42 <\/figcaption><\/figure>\n

Dar cea mai mare veste a venit de la un studiu clinic la scar\u0103 mic\u0103 publicat cu o zi \u00eenainte. Titlul este Hidroxiclorochin\u0103 \u0219i azitromicin\u0103 ca tratament al COVID-19: rezultatele unui studiu clinic deschis non-randomizat \u0219i poate fi desc\u0103rcat \u00een versiunea sa \"\u00een pres\u0103\"<\/a><\/p>\n

\u00centr-un studiu cu doar 20 de pacien\u021bi, autorii au ar\u0103tat c\u0103 hidroxiclorochina a fost eficient\u0103 \u00eempotriva infec\u021biei cu coronavirusul Covid-19. De fapt, a redus 75% de indivizi infecta\u021bi \u00een perioada de 6 zile, ceea ce este impresionant. Chiar mai bine dec\u00e2t at\u00e2t, combina\u021bia cu azitromicina a \u00eembun\u0103t\u0103\u021bit eficacitatea tratamentului la 95%.<\/p>\n

\"Terapia
Terapia combinat\u0103 cu hidrohychloroquine \u0219i azitromicin\u0103 este eficient\u0103 \u00eempotriva infec\u021biilor cu coronavirus (Covid-19) la pacien\u021bii umani. Sc\u0103derea este dramatic\u0103 \u0219i aduce o nou\u0103 speran\u021b\u0103 pentru pacien\u021bii afecta\u021bi.<\/figcaption><\/figure>\n

Tratamentul a \u00eembun\u0103t\u0103\u021bit simptomele, reduc\u00e2nd \u00een acela\u0219i timp \u00eenc\u0103rc\u0103tura viral\u0103 a pacien\u021bilor. Medicamentul a fost aprobat anterior pentru malarie, ceea ce \u00eenseamn\u0103 c\u0103 este considerat sigur. Medicamentul \"sor\u0103\" clorochin\u0103 a fost mai pu\u021bin eficient. E bine pentru noi, pentru c\u0103 este ceva mai toxic.<\/p>\n

Studiul nu a fost randomizat \u0219i a fost realizat la scar\u0103 mic\u0103, \u00eens\u0103 se pare c\u0103, de\u0219i epidemia a \u00eenceput \u00een China, solu\u021bia provine dintr-un efort comunitar global. Lucrarea in vitro este de fapt chinez\u0103, \u00een timp ce cea clinic\u0103 este european\u0103, mai exact din Fran\u021ba. Interesant este faptul c\u0103 \u00eenregistr\u0103rile ini\u021biale ale medicamentului hidroxiclorochina provin de la compania farmaceutic\u0103 francez\u0103 Sanofi, iar studiul clinic recent a fost efectuat la Marsilia. Ale le bleu!<\/p>\n

Medscape are un articol excelent despre aceasta, pentru cei interesa\u021bi de informa\u021bii mai detaliate.<\/a><\/p>\n

V\u0103 rug\u0103m s\u0103 cita\u021bi aceast\u0103 lucrare ca fiind Gautret et al. (2020) Hidroxiclorochina \u0219i azitromicina ca tratament al COVID-19: rezultatele unui studiu clinic non-randomizat deschis. International Journal of Antimicrobial Agents - \u00cen pres\u0103 17 martie 2020 - DOI : 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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