{"id":5346,"date":"2016-03-03T13:41:11","date_gmt":"2016-03-03T16:41:11","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=5346"},"modified":"2022-10-18T08:29:24","modified_gmt":"2022-10-18T11:29:24","slug":"zika-virus-graphical-abstract","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pt\/zika-virus-graphical-abstract\/","title":{"rendered":"Resumo gr\u00e1fico do v\u00edrus Zika sobre microcefalia"},"content":{"rendered":"

Entenda o resumo gr\u00e1fico do v\u00edrus Zika: Como ele reduz o tamanho do c\u00e9rebro<\/h3>\n

Hoje, um estudo de pesquisa acrescentou evid\u00eancias interessantes sobre o papel do v\u00edrus Zika na malforma\u00e7\u00e3o dos tecidos nervosos. Ah, sim, antes que voc\u00ea pergunte, tecido nervoso humano.<\/p>\n

Isto foi feito elegantemente pelo grupo do Dr. Stevens Rehen, um pesquisador internacionalmente conhecido no campo da pesquisa de c\u00e9lulas-tronco e, mais recentemente, da reprograma\u00e7\u00e3o celular.<\/p>\n

A figura abaixo resume as conclus\u00f5es de o papel<\/a>mas vou tentar explicar brevemente.<\/p>\n

 <\/p>\n

\"blog<\/p>\n

Este resumo gr\u00e1fico do v\u00edrus Zika foi feito com o gr\u00e1fico Mind the Graphical. N\u00e3o \u00e9 legal?<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

Como voc\u00ea pode ver na foto acima, tr\u00eas abordagens distintas foram tomadas nesta pesquisa. Todas elas confirmando que o v\u00edrus Zika tem um impacto direto em como as c\u00e9lulas cerebrais evoluem para formar um tecido neuronal adequado, tamb\u00e9m conhecido como \"incide na malforma\u00e7\u00e3o cerebral\".\"resumo<\/a>A microcefalia \u00e9 apenas uma malforma\u00e7\u00e3o cerebral. O que o papel sugere \u00e9 algo ainda mais fundamental.<\/p>\n

Eles mostram como o v\u00edrus Zika:<\/p>\n

    \n
  1. Promove a morte da c\u00e9lula<\/li>\n
  2. Induz altera\u00e7\u00f5es morfol\u00f3gicas (em neurosferas)<\/li>\n
  3. Reduz o crescimento\/tamanho dos organ\u00f3ides cerebrais (mini-c\u00e9rebros)<\/li>\n<\/ol>\n

    Estas s\u00e3o todas as formas como o v\u00edrus Zika afeta a neurog\u00eanese durante o desenvolvimento do c\u00e9rebro humano e causa o fen\u00f3tipo que voc\u00ea v\u00ea abaixo.<\/p>\n

    \"resumo<\/a><\/p>\n

    <\/h3>\n

    Por que isso n\u00e3o foi feito antes?<\/h3>\n

    A abordagem inovadora foi o uso de c\u00e9lulas-tronco de plurpot\u00eancia induzida (c\u00e9lulas iPS) para poder estudar a infec\u00e7\u00e3o por v\u00edrus em c\u00e9lulas humanas.<\/p>\n

    Com este processo, uma c\u00e9lula som\u00e1tica colhida de uma pessoa \u00e9 reprogramada em dire\u00e7\u00e3o ao seu estado inicial de c\u00e9lula pluripotente e pode depois ser diferenciada em diferentes c\u00e9lulas, tecidos e, mais recentemente, \u00f3rg\u00e3os. Este \u00e9 o pr\u00f3prio in\u00edcio da \"engenharia de tecidos humanos\".<\/p>\n

    No estudo, os autores n\u00e3o apenas utilizaram as c\u00e9lulas iPS, mas geraram organ\u00f3ides do c\u00e9rebro<\/a>A presen\u00e7a do v\u00edrus Zika tamb\u00e9m \u00e9 conhecida como \"mini-c\u00e9rebros\" para entender como a presen\u00e7a do v\u00edrus Zika afeta a forma\u00e7\u00e3o deste tecido neuronal.<\/p>\n

    Culturas celulares como esta s\u00e3o consideradas estruturas tridimensionais (3D) e fornecem mais dicas sobre a arquitetura do \u00f3rg\u00e3o. Este \u00e9 o ano do organ\u00f3ide, de acordo com o Economista<\/a>. Usando esta abordagem inovadora, os cientistas puderam entender como o v\u00edrus zika visa as c\u00e9lulas cerebrais humanas reduzindo sua viabilidade e crescimento como neurosferas e organ\u00f3ides cerebrais.<\/p>\n

    O papel<\/a> est\u00e1 em pr\u00e9-impress\u00e3o na revista inovadora PeerJ. Voc\u00ea pode at\u00e9 comentar e ajudar os autores a melhor\u00e1-la durante o processo. Voc\u00ea pode ver o resumo abaixo e ter acesso completo, clicando em aqui<\/a>.<\/p>\n

    \"resumo<\/a><\/p>\n

    Nota: Dois meses ap\u00f3s a pr\u00e9-impress\u00e3o no PeerJ datada de mar\u00e7o de 2016, o papel final foi lan\u00e7ado e, para nossa surpresa, foi publicado no Science <\/a>Magazine, uma das revistas cient\u00edficas de maior prest\u00edgio do planeta.<\/p>\n

    -> Leia o artigo completo de Garcez et al em Science <-<\/a><\/p>\n

    \"resumo<\/a><\/p>\n

    Deixe que mais pessoas saibam sobre isso compartilhando este posto. Esta \u00e9 uma quest\u00e3o de sa\u00fade p\u00fablica global, como j\u00e1 foi dito pelo Organiza\u00e7\u00e3o Mundial da Sa\u00fade<\/a>\u00a0(OMS).<\/p>\n

    \n

     <\/p>\n

    Saiba o que o Os conselhos da OMS sobre o v\u00edrus Zika<\/a>\u00a0transmiss\u00e3o e infec\u00e7\u00e3o:<\/p>\n

    \n

    Transmiss\u00e3o<\/h3>\n

    O v\u00edrus Zika \u00e9 transmitido principalmente para humanos atrav\u00e9s de mordidas de Aedes<\/i> mosquitos, que muitas vezes vivem ao redor de edif\u00edcios em \u00e1reas urbanas e s\u00e3o geralmente ativos durante o dia (o pico de atividade de picada ocorre no in\u00edcio da manh\u00e3 e no final da tarde).<\/p>\n

    Algumas evid\u00eancias sugerem que o v\u00edrus Zika tamb\u00e9m pode ser transmitido para humanos atrav\u00e9s de transfus\u00e3o de sangue, transmiss\u00e3o perinatal e transmiss\u00e3o sexual. No entanto, estes modos s\u00e3o muito raros.<\/p>\n

    O per\u00edodo de incuba\u00e7\u00e3o \u00e9 normalmente entre 2 e 7 dias.<\/p>\n

    Sinais e sintomas<\/h3>\n

    A infec\u00e7\u00e3o pelo v\u00edrus Zika \u00e9 caracterizada por febre baixa (menos de 38,5\u00b0C) frequentemente acompanhada por uma erup\u00e7\u00e3o cut\u00e2nea maculopapular. Outros sintomas comuns incluem dor muscular, dor articular com poss\u00edvel incha\u00e7o (notavelmente das pequenas articula\u00e7\u00f5es das m\u00e3os e p\u00e9s), dor de cabe\u00e7a, dor atr\u00e1s dos olhos e conjuntivite. Como os sintomas s\u00e3o freq\u00fcentemente leves, a infec\u00e7\u00e3o pode passar despercebida ou ser mal diagnosticada como dengue.<\/p>\n

    Espera-se uma alta taxa de infec\u00e7\u00e3o assintom\u00e1tica com o v\u00edrus Zika, semelhante a outros flaviv\u00edrus, como o v\u00edrus da dengue e o v\u00edrus do Nilo Ocidental. A maioria das pessoas se recupera totalmente sem complica\u00e7\u00f5es graves, e as taxas de hospitaliza\u00e7\u00e3o s\u00e3o baixas. At\u00e9 o momento, n\u00e3o houve relatos de mortes associadas ao v\u00edrus Zika.<\/p><\/blockquote>\n

     <\/p>\n

    Atualizado em 3 de maio de 2016.<\/p>","protected":false},"excerpt":{"rendered":"

    Entenda o resumo gr\u00e1fico do v\u00edrus Zika: Como ele reduz o tamanho do c\u00e9rebro Hoje um estudo de pesquisa acrescentou evid\u00eancias interessantes sobre o papel do v\u00edrus Zika na malforma\u00e7\u00e3o dos tecidos nervosos. Ah, sim, antes que voc\u00ea pergunte, tecido nervoso humano. Isto foi feito elegantemente pelo grupo do Dr. Stevens Rehen, um pesquisador internacionalmente conhecido na \u00e1rea de [...]<\/p>","protected":false},"author":4,"featured_media":7136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[956],"tags":[96,201,200,203,202,205,554,71,250,204,199],"yoast_head":"\nZika virus graphical abstract on microcephaly - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This insightful Zika virus graphical abstract was done with Mind the graph. 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