{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pt\/sucesso-case-nuclear-receptores-em-fibrose-hepatica\/","title":{"rendered":"Receptores nucleares em fibrose hep\u00e1tica Revis\u00e3o de papel"},"content":{"rendered":"

Neste caso, o autor utilizou o Mind the Graph para compilar n\u00fameros de diferentes fontes em um s\u00f3 lugar. Al\u00e9m das melhores ilustra\u00e7\u00f5es precisas da ci\u00eancia, nosso espa\u00e7o de trabalho tem uma interface amig\u00e1vel e \u00e9 muito f\u00e1cil de usar.<\/p>\n\n\n\n

Verifique o completo artigo original<\/a>. <\/p>\n\n\n\n

Papel dos receptores nucleares na fibrose hep\u00e1tica<\/strong><\/h2>\n\n\n\n

Philipp K\u00f6nigshofer et al. (2021) relatam que os receptores nucleares s\u00e3o fatores de transcri\u00e7\u00e3o ativados por liga\u00e7\u00e3o e que regulam a express\u00e3o g\u00eanica de uma variedade de sinais moleculares chave envolvidos na fibrose hep\u00e1tica. <\/p>\n\n\n\n

O condutor celular prim\u00e1rio da fibrog\u00eanese hep\u00e1tica \u00e9 as c\u00e9lulas esteladas hep\u00e1ticas ativadas. Diferentes receptores nucleares regulam a express\u00e3o hep\u00e1tica das citocinas pr\u00f3-inflamat\u00f3rias e pr\u00f3-fibrog\u00eanicas.<\/p>\n\n\n\n

Resumos gr\u00e1ficos alimentados por Mind the Graph<\/strong> neste artigo<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Feito com Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n
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Esta primeira figura \u00e9 uma vis\u00e3o geral e classifica\u00e7\u00e3o dos receptores nucleares por subfam\u00edlias.<\/p>\n\n\n\n

<\/div>\n\n\n
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Feito com Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Acima, podemos ver os diferentes tipos de fun\u00e7\u00f5es do efetor receptor nuclear.<\/p>\n\n\n\n

<\/div>\n\n\n
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Feito com Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Na terceira figura, podemos verificar uma vis\u00e3o geral dos efeitos relatados das modula\u00e7\u00f5es NR como abordagens terap\u00eauticas potenciais contra doen\u00e7as hep\u00e1ticas. <\/p>\n\n\n\n

As setas indicam os supostos efeitos ben\u00e9ficos na doen\u00e7a hep\u00e1tica por para cima... (verde escuro)<\/strong><\/span> ou para baixo- (verde claro)<\/span><\/strong> regulamenta\u00e7\u00e3o de mecanismos espec\u00edficos que foram relatados para apoiar a regress\u00e3o da fibrose hep\u00e1tica ou para reduzir a fibrose hep\u00e1tica. <\/p>\n\n\n\n

Setas cor-de-laranja<\/mark><\/strong> indicam efeitos e mecanismos de modula\u00e7\u00e3o NR que ou s\u00e3o controversos ou ainda insuficientemente avaliados.<\/p>\n\n\n\n

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Feito com Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

A \u00faltima figura representa os efeitos moleculares dos moduladores NR como um tratamento potencial para a fibrose hep\u00e1tica que, segundo relatos, ocorre predominantemente dentro dos HSCs.<\/p>\n\n\n\n

K\u00f6nigshofer e colegas prop\u00f5em que novas pesquisas sobre sinaliza\u00e7\u00e3o relacionada a receptores nucleares podem levar ao desenvolvimento cl\u00ednico de terapias anti-fibr\u00f3ticas eficazes para pacientes com doen\u00e7as hep\u00e1ticas.<\/p>\n\n\n\n

Impacto e desempenho dos trabalhos<\/strong><\/h2>\n\n\n\n

Selecionando uma op\u00e7\u00e3o de 1 ano de compara\u00e7\u00e3o de m\u00e9tricas com outros artigos\/revis\u00f5es que tamb\u00e9m foram publicados no mesmo ano civil naquela Revista, podemos notar que este artigo foi mais citado do que 57% deles<\/strong>.<\/p>\n\n\n

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Fonte PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Use o poder dos infogr\u00e1ficos para impulsionar seu artigo tamb\u00e9m. Experimente o Mind the Graph!<\/p>\n\n\n\n

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Experimente Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Este artigo tem ilustra\u00e7\u00f5es cient\u00edficas feitas com Mind the Graph para representar os receptores nucleares em fibrose hep\u00e1tica.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nNuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/pt\/sucesso-case-nuclear-receptores-em-fibrose-hepatica\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/pt\/sucesso-case-nuclear-receptores-em-fibrose-hepatica\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-16T22:40:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nuclear receptors in liver fibrosis Paper Review - 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