{"id":16657,"date":"2022-09-14T13:04:15","date_gmt":"2022-09-14T16:04:15","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16657"},"modified":"2023-03-17T14:47:26","modified_gmt":"2023-03-17T17:47:26","slug":"success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pt\/success-case-xtalkdb-a-database-de-sinalizacao-patabase-de-estrada-crosstalk\/","title":{"rendered":"XTALKDB: um banco de dados de an\u00e1lise de papel de sinaliza\u00e7\u00e3o de vias cruzadas"},"content":{"rendered":"

Este incr\u00edvel artigo traz \u00e0 tona estat\u00edsticas resumindo os dados no XTALKDB. Em apenas alguns minutos, o autor criou um infogr\u00e1fico explicando a distribui\u00e7\u00e3o da esp\u00e9cie no XTALKDB.<\/p>\n\n\n\n

Verifique o artigo original aqui<\/a>.<\/p>\n\n\n\n

Como os seres humanos s\u00e3o criaturas visuais, as imagens ainda s\u00e3o a melhor maneira de explicar sua pesquisa com tantos detalhes quanto voc\u00ea quiser.<\/p>\n\n\n\n

Os cientistas desenvolveram um banco de dados que documenta o cruzamento entre pares espec\u00edficos de caminhos de sinaliza\u00e7\u00e3o e as esp\u00e9cies e tecidos em que s\u00e3o observados.<\/strong><\/h2>\n\n\n\n

Um grupo de pesquisa liderado por Sarah Sam do Departamento de Ci\u00eancias Biol\u00f3gicas (2016) relatou que a percep\u00e7\u00e3o de um sinal externo pelos receptores faz com que as atividades das prote\u00ednas intermedi\u00e1rias mudem. <\/p>\n\n\n\n

Isto resulta na regulamenta\u00e7\u00e3o dos fatores de transcri\u00e7\u00e3o, que modulam a express\u00e3o dos genes alvo. Para cada par de caminhos, o XTalkDB registra informa\u00e7\u00f5es detalhadas descrevendo as condi\u00e7\u00f5es experimentais sob as quais o crosstalk foi descoberto. <\/p>\n\n\n\n

As c\u00e9lulas avaliam e respondem ao seu ambiente atrav\u00e9s de caminhos de sinaliza\u00e7\u00e3o. Um caminho de sinaliza\u00e7\u00e3o normalmente cont\u00e9m um conjunto bem definido de intera\u00e7\u00f5es reguladoras e f\u00edsicas entre os receptores, prote\u00ednas de sinaliza\u00e7\u00e3o intermedi\u00e1rias, fatores de transcri\u00e7\u00e3o e genes alvo. <\/p>\n\n\n\n

O site XTalkDB fornece uma interface f\u00e1cil de usar para os cientistas navegarem pelas informa\u00e7\u00f5es de crosstalk, consultando um ou mais caminhos ou mol\u00e9culas de interesse.<\/p>\n\n\n\n

Havia 650 pares inclu\u00eddos no estudo.<\/strong><\/p>\n\n\n\n

Resumo gr\u00e1fico alimentado por Mind the Graph<\/strong><\/h2>\n\n\n
\n
\"success-case-XTALKDB-a-database<\/a>
Feito com Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Discutindo poss\u00edveis melhorias, \"O processo de cura manual subjacente ao XTalkDB tem suas limita\u00e7\u00f5es, especialmente quando procuramos expandir a cobertura do banco de dados. <\/p>\n\n\n\n

Planejamos desenvolver uma estrutura de processamento de linguagem natural que classificar\u00e1 as publica\u00e7\u00f5es com base em sua probabilidade de documentar os crosstalk. Um curador pode ent\u00e3o se concentrar em publica\u00e7\u00f5es altamente classificadas\", eles admitem.<\/p>\n\n\n\n

Impacto e desempenho dos trabalhos<\/strong><\/h2>\n\n\n\n

Podemos analisar com Altmetric<\/a> dados que este documento est\u00e1 no parte superior de todas as m\u00e9tricas dentro de todos os artigos financiados pelo NIH nas Dimens\u00f5es. <\/strong><\/p>\n\n\n

\n
\"\"<\/a>
Fonte: https:\/\/badge.dimensions.ai\/details\/id\/pub.1052462103<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Use o poder dos infogr\u00e1ficos para impulsionar seu artigo tamb\u00e9m. Experimente o Mind the Graph!<\/p>\n\n\n\n

<\/div>\n\n\n\n
\n
Experimente Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Aprenda com aqueles que j\u00e1 descobriram o poder da infografia. Este artigo tem resumos gr\u00e1ficos feitos com o Mind the Graph. <\/p>","protected":false},"author":29,"featured_media":20046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"\nXTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/pt\/success-case-xtalkdb-a-database-de-sinalizacao-patabase-de-estrada-crosstalk\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"XTALKDB: a database of signaling pathway crosstalk Paper Review - 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