{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pt\/sucesso-case-resolucao-synchrotron-x-raio-microtomografia-como-uma-ferramenta-para-revelar-a-arquitetura-tridimensional-neuronal-arquitetura-do-cerebro\/","title":{"rendered":"Microtomografia de raios X sincrotr\u00f4nicos de alta resolu\u00e7\u00e3o como ferramenta para desvendar a arquitetura neuronal tridimensional do c\u00e9rebro Revis\u00e3o de Papel"},"content":{"rendered":"

A microtomografia de raios X surgiu como um novo m\u00e9todo para decifrar a citoarquitetura e a conectividade do c\u00e9rebro, e aqui apresentamos um m\u00e9todo para a imagem de neur\u00f4nios inteiros.<\/p>\n\n\n\n

Microtomografia de raios X sincrotr\u00f4nicos de alta resolu\u00e7\u00e3o como ferramenta para revelar a arquitetura neuronal tridimensional do c\u00e9rebro<\/strong><\/h2>\n\n\n\n

Em 'Highresolution synchrotron-based X-ray microtomography as a tool to unveil the tridimensional neuronal architecture of the brain', Matheus de Castro Fonseca et al. (2018) observaram que o estudo dos neur\u00f4nios como unidades individualizadas tem seu in\u00edcio no s\u00e9culo 19 com a cria\u00e7\u00e3o da Doutrina Neuronal. <\/p>\n\n\n\n

Nos \u00faltimos anos, foram feitos grandes esfor\u00e7os para compreender a organiza\u00e7\u00e3o neuronal e a conectividade em amostras cerebrais intactas. A t\u00e9cnica de rotula\u00e7\u00e3o Golgi-Cox oferece contraste adequado para a rotula\u00e7\u00e3o espec\u00edfica de neur\u00f4nios para microtomografia de raios X. <\/p>\n\n\n\n

Os neur\u00f4nios t\u00eam uma morfologia distinta e padr\u00f5es espec\u00edficos de conectividade, que s\u00e3o essenciais para seu bom funcionamento. Os pesquisadores apresentam um m\u00e9todo de imagem que combina a microtomografia de raios X sincrotr\u00f4nica com o protocolo de impregna\u00e7\u00e3o Golgi-Cox. <\/p>\n\n\n\n

O m\u00e9todo oferece um contraste maior e mais homog\u00eaneo de neur\u00f4nios inteiros relativamente escassamente distribu\u00eddos dentro do tecido.<\/p>\n\n\n\n

Os c\u00e9rebros foram incubados em solu\u00e7\u00e3o de colora\u00e7\u00e3o Golgi-Cox por 14 dias, protegidos da luz. Ap\u00f3s o per\u00edodo de incuba\u00e7\u00e3o, os c\u00e9rebros foram seccionados em s\u00e9rie utilizando um vibratome.<\/strong><\/p>\n\n\n\n

Verifique o artigo original aqui<\/a>.<\/p>\n\n\n\n

Resumo gr\u00e1fico alimentado por Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Feito com Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

O autor utilizou Mind the Graph<\/a> para criar uma ilustra\u00e7\u00e3o esquem\u00e1tica que representa um rato adulto sendo injetado i.p. com solu\u00e7\u00e3o salina ou pilocarpina (280\u2009mg\/kg). Representar processos complexos com infogr\u00e1ficos \u00e9 uma boa maneira de torn\u00e1-los facilmente compreens\u00edveis, sem deixar de lado os detalhes e informa\u00e7\u00f5es cruciais.<\/p>\n\n\n\n

Alguns dos resultados dos pesquisadores parecem consolidar o que era conhecido anteriormente sobre esta \u00e1rea: \"A impregna\u00e7\u00e3o de neur\u00f4nios \u00e0 base de merc\u00fario mostrou aqui, nos permitiu definir claramente neur\u00f4nios inteiros principalmente por causa de uma impregna\u00e7\u00e3o mais cont\u00ednua e homog\u00eanea das c\u00e9lulas e uma densidade muito reduzida de artefatos\", sugeriu de Castro Fonseca.<\/p>\n\n\n\n

Impacto e desempenho dos trabalhos<\/strong><\/h2>\n\n\n\n

Podemos analisar com Altmetric<\/a> dados de que a pontua\u00e7\u00e3o de aten\u00e7\u00e3o online deste artigo \u00e9 maior do que 64%<\/strong><\/strong> de todos os outros artigos de idade semelhante nos Relat\u00f3rios Cient\u00edficos.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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Fonte Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Melhore a acessibilidade de seu artigo tamb\u00e9m com o poder dos infogr\u00e1ficos.<\/p>\n\n\n\n

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Experimente Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Veja o novo m\u00e9todo para decifrar a citoarquitetura e a conectividade do c\u00e9rebro representado com as ilustra\u00e7\u00f5es do Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/pt\/sucesso-case-resolucao-synchrotron-x-raio-microtomografia-como-uma-ferramenta-para-revelar-a-arquitetura-tridimensional-neuronal-arquitetura-do-cerebro\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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