{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pt\/sucesso-case-zika-virus-replica-em-adulto-cerebro-humano-tissue-e-para-synapses-and-memory-in-mice\/","title":{"rendered":"O v\u00edrus Zika replica em tecido cerebral humano adulto e prejudica as sinapses e a mem\u00f3ria em ratos Revis\u00e3o de papel"},"content":{"rendered":"

O ZIKV \u00e9 um v\u00edrus perigoso que assola o mundo. Portanto, neste caso, o autor estuda sua replica\u00e7\u00e3o no c\u00e9rebro humano adulto.<\/p>\n\n\n\n

O v\u00edrus Zika (ZIKV) infecta o tecido cerebral de adultos e causa problemas de mem\u00f3ria em camundongos<\/strong><\/h2>\n\n\n\n

Um grupo da Escola de Farm\u00e1cia liderado por Claudia Figueiredo (2019) estudou como o v\u00edrus zika se replica no tecido cerebral humano adulto e prejudica as sinapses e a mem\u00f3ria em camundongos. O v\u00edrus Zika \u00e9 um arbov\u00edrus pertencente \u00e0 fam\u00edlia Flaviviridae respons\u00e1vel por um grande surto recente na Am\u00e9rica Latina. <\/p>\n\n\n\n

ZIKV foi encontrado no c\u00e9rebro e no LCR de pacientes adultos. A imunoreatividade NS2B colocou-se com c\u00e9lulas imunoativas NeuN, mas n\u00e3o com GFAP ou F4\/80, indicando que os neur\u00f4nios s\u00e3o visados pelo ZikV no tecido humano maduro. Em ratos adultos imunocompetentes infectados pela infus\u00e3o intracerebroventricular de ZIKV, n\u00edveis elevados de RNA ZikV s\u00e3o detectados no c\u00f3rtex frontal e no hipocampo, e os neur\u00f4nios maduros s\u00e3o os principais tipos de c\u00e9lulas infectadas. <\/p>\n\n\n\n

N\u00edveis elevados de TNF-\u03b1, microgliose intensa, express\u00e3o upregulada das prote\u00ednas do sistema complemento (C1q e C3), e danos na sinapse hipocampal s\u00e3o verificados.<\/p>\n\n\n\n

O estudo envolveu 9 quadrantes iguais.<\/strong><\/p>\n\n\n\n

Verifique o artigo original aqui<\/a>.<\/p>\n\n\n\n

Resumos gr\u00e1ficos alimentados por Mind the Graph<\/strong><\/h2>\n\n\n\n
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Feito com Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

A primeira figura representa o caso em que os fragmentos de tecido cortical do lobo temporal humano foram seccionados em fatias 400\u2009\u00b5m e mantidos em cultura por 4 dias antes da incuba\u00e7\u00e3o com ZIKV (107 PFU) ou meio falso para 1\u2009h, seguido de washout. <\/p>\n\n\n\n

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Feito com Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

O segundo mostra que ratos adultos receberam uma infus\u00e3o de 105 PFU ZIKV, ZIKV ativada por UV ou meio falso no ventr\u00edculo lateral cerebral.<\/p>\n\n\n\n

As conclus\u00f5es parecem confirmar o que se sabia anteriormente sobre este assunto: \"ZIKV tem como alvo regi\u00f5es cerebrais relacionadas \u00e0 mem\u00f3ria, independentemente de a rota da infec\u00e7\u00e3o ser central ou perif\u00e9rica. O v\u00edrus foi detectado no LCR de pacientes adultos com complica\u00e7\u00f5es neurol\u00f3gicas\", afirmou Figueiredo.<\/p>\n\n\n\n

Eles prop\u00f5em que estudos futuros com o objetivo de examinar o impacto neurodegenerativo a longo prazo da infec\u00e7\u00e3o pelo ZIKV sejam justificados. Identificar maneiras de prevenir anormalidades de sinaliza\u00e7\u00e3o que levem a disfun\u00e7\u00f5es cerebrais poderia abrir o caminho para estrat\u00e9gias de interven\u00e7\u00e3o para retardar ou impedir o desenvolvimento de condi\u00e7\u00f5es neurol\u00f3gicas importantes.<\/p>\n\n\n\n

Impacto e desempenho dos trabalhos<\/strong><\/h2>\n\n\n\n

Podemos analisar com Altmetric<\/a> dados de que a pontua\u00e7\u00e3o de aten\u00e7\u00e3o online deste artigo \u00e9 maior do que 95%<\/strong><\/strong> de todos os outros artigos de uma idade semelhante na Natureza<\/strong> Revistas.<\/strong><\/p>\n\n\n\n

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Fonte Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Use o poder dos infogr\u00e1ficos para impulsionar seu artigo tamb\u00e9m! Comece uma cria\u00e7\u00e3o no Mind the Graph.<\/p>\n\n\n\n

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Experimente Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

O estudo \u00e9 sobre o ZIKV no c\u00e9rebro humano adulto, um v\u00edrus perigoso que assola o mundo. O processo utiliza ilustra\u00e7\u00f5es do Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/pt\/sucesso-case-zika-virus-replica-em-adulto-cerebro-humano-tissue-e-para-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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