{"id":12175,"date":"2021-01-25T09:30:00","date_gmt":"2021-01-25T11:30:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12175"},"modified":"2023-05-22T11:11:05","modified_gmt":"2023-05-22T14:11:05","slug":"molecular-control-knob-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pt\/molecular-controle-cerebro-cerebro\/","title":{"rendered":"Um \"Bot\u00e3o de Controle Molecular\" em O C\u00e9rebro que Auxilia na Aprendizagem e Mem\u00f3ria"},"content":{"rendered":"<p>Cada m\u00e1quina tem um painel de controle para controlar v\u00e1rias fun\u00e7\u00f5es, especialmente o mecanismo de ligar e desligar. <\/p>\n\n\n\n<p>J\u00e1 se perguntou se nosso c\u00e9rebro tamb\u00e9m tinha um onde se pudesse controlar as fun\u00e7\u00f5es do c\u00e9rebro? <\/p>\n\n\n\n<p>Bem, novas pesquisas sugerem um \"bot\u00e3o molecular de volume\" que regula os sinais el\u00e9tricos no c\u00e9rebro em aprendizagem e especialmente com a mem\u00f3ria. <\/p>\n\n\n\n<p>Este poderia ser o mecanismo de interruptor principal que poderia ser um modificador de jogo para dist\u00farbios neurais.<\/p>\n\n\n\n<p>A pesquisa publicada por Michael Hoppa e sua equipe sugere como a regula\u00e7\u00e3o de sinais el\u00e9tricos poderia desempenhar um papel importante. O estudo girava em torno da identifica\u00e7\u00e3o das mol\u00e9culas que regulavam o sinal.<\/p>\n\n\n\n<p>A NO\u00c7\u00c3O POR TR\u00c1S DA PESQUISA<\/p>\n\n\n\n<p>As sinapses s\u00e3o a jun\u00e7\u00e3o onde os sinais el\u00e9tricos s\u00e3o transmitidos entre as c\u00e9lulas nervosas. <\/p>\n\n\n\n<p>Estes sinais el\u00e9tricos s\u00e3o convertidos em neurotransmissores qu\u00edmicos pelo c\u00e9rebro que viaja atrav\u00e9s de lacunas sin\u00e1pticas. A equipe descreveu como as formas dos sinais el\u00e9tricos beneficiam o funcionamento das sinapses. <\/p>\n\n\n\n<p>Os neur\u00f4nios que s\u00e3o ativados durante a neurotransmiss\u00e3o t\u00eam padr\u00f5es diferentes. <\/p>\n\n\n\n<p>Estas mudan\u00e7as nas formas e n\u00fameros levam ao fortalecimento ou enfraquecimento das sinapses (tamb\u00e9m conhecidas como plasticidade sin\u00e1ptica). <\/p>\n\n\n\n<p>Quando as c\u00e9lulas cerebrais encontradas em ambas as extremidades da sinapse trocam continuamente sinais qu\u00edmicos, ocorre uma potencializa\u00e7\u00e3o a longo prazo (LTP). <\/p>\n\n\n\n<p>Este LTP melhora a sinaliza\u00e7\u00e3o entre c\u00e9lulas e sinapses e tamb\u00e9m leva ao fortalecimento das sinapses. Este LTP \u00e9 a base para o aprendizado e a mem\u00f3ria no c\u00e9rebro em um local chamado hipocampo.<\/p>\n\n\n\n<p>Os pesquisadores concentraram seu estudo na \u00e1rea do hipocampo no c\u00e9rebro. Eles descobriram que os sinais transmitidos atrav\u00e9s da sinapse nesta \u00e1rea eram an\u00e1logos. <\/p>\n\n\n\n<p>A equipe descobriu que os sinais el\u00e9tricos ou os \"picos\" eram entregues na forma de sinais anal\u00f3gicos e n\u00e3o digitais. <\/p>\n\n\n\n<p>Esta descoberta abriu o caminho para uma compreens\u00e3o mais clara do mecanismo. Estes sinais anal\u00f3gicos facilitaram a regula\u00e7\u00e3o da for\u00e7a do circuito do c\u00e9rebro.<\/p>\n\n\n\n<p>A mol\u00e9cula que regula esses sinais el\u00e9tricos tamb\u00e9m foi encontrada. A mol\u00e9cula Kv\u03b21 ampliou a a\u00e7\u00e3o pr\u00e9-sin\u00e1ptica. <\/p>\n\n\n\n<p>Esta mol\u00e9cula n\u00e3o apenas regula a corrente de pot\u00e1ssio, mas tamb\u00e9m ajuda a moldar os sinais el\u00e9tricos. <\/p>\n\n\n\n<p>Quando anteriormente realizaram a experi\u00eancia, exclu\u00edram a mol\u00e9cula Kv\u03b21 nos ratos. Logo os resultados mostraram uma rea\u00e7\u00e3o oposta, houve um impacto dr\u00e1stico sobre o ciclo de sono e mem\u00f3ria dos ratos. <\/p>\n\n\n\n<p>Isto confirmou a a\u00e7\u00e3o positiva realizada pela mol\u00e9cula no sistema.<\/p>\n\n\n\n<p>Al\u00e9m disso, suas pesquisas tamb\u00e9m revelam como um \u00fanico impulso el\u00e9trico pode transportar v\u00e1rios bits da informa\u00e7\u00e3o que permite maior controle em sinais de baixa freq\u00fc\u00eancia. <\/p>\n\n\n\n<p>Isto significa que nosso c\u00e9rebro \u00e9 muito mais eficiente do que se pode imaginar. Tecnicamente, nosso c\u00e9rebro realiza tarefas super-computacionais com baixa sinaliza\u00e7\u00e3o el\u00e9trica. <\/p>\n\n\n\n<p>Suas pesquisas possibilitaram a medi\u00e7\u00e3o da tens\u00e3o e do neurotransmissor usando luz que, por sua vez, mediu os sinais el\u00e9tricos nos locais de conex\u00e3o sin\u00e1ptica. <\/p>\n\n\n\n<p>Isto mudou a perspectiva, bem como ampliou o escopo da pesquisa no campo dos reguladores moleculares que desempenham um papel vital na atividade cerebral.<\/p>\n\n\n\n<p>Esta descoberta permite todo um novo caminho para a ind\u00fastria farmac\u00eautica. Isto poderia levar \u00e0 descoberta de novos medicamentos em caso de dem\u00eancia ou Alzheimer. <\/p>\n\n\n\n<p>Os reguladores moleculares poderiam ser a chave para utilizar toda a capacidade cerebral. Muitas doen\u00e7as neurol\u00f3gicas poderiam ser curadas se for encontrado o caminho certo para o metabolismo cerebral. <\/p>\n\n\n\n<p>Como dizem que o aprendizado nunca esgota a mente, \u00e9 um poder que pode mudar o mundo. Esta descoberta sem d\u00favida leva a um n\u00edvel totalmente novo de aprendizagem e poder de se agarrar a ela.<\/p>\n\n\n\n<p>Para saber mais sobre suas pesquisas, confira a refer\u00eancia dada abaixo.<\/p>\n\n\n\n<p>Refer\u00eancia :<\/p>\n\n\n\n<p>Em Ha Cho, Lauren C. Panzera, Morven Chin, Scott A. Alpizar, Genaro E. Olveda, Robert A. Hill, Michael B. Hoppa. A subunidade do canal de pot\u00e1ssio Kv\u03b21 serve como um importante ponto de controle para facilita\u00e7\u00e3o sin\u00e1ptica. Anais da Academia Nacional de Ci\u00eancias, 2020; 202000790<\/p>\n\n\n\n<p>DOI: 10.1073\/pnas.2000790117<\/p>","protected":false},"excerpt":{"rendered":"<p>Cada m\u00e1quina tem um painel de controle para controlar v\u00e1rias fun\u00e7\u00f5es, especialmente o mecanismo de ligar e desligar. J\u00e1 se perguntou se nosso c\u00e9rebro tamb\u00e9m tinha um onde se pudesse controlar as fun\u00e7\u00f5es do c\u00e9rebro? Bem, novas pesquisas sugerem um \"bot\u00e3o molecular de volume\" que regula os sinais el\u00e9tricos no c\u00e9rebro em aprendizagem e especialmente [...]<\/p>","protected":false},"author":4,"featured_media":12176,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[54,245,554],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The \u201cmolecular control knob\u201d that aids learning and memory - MTG<\/title>\n<meta name=\"description\" content=\"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/pt\/molekularni-nadzor-kljuc-mozgani\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The \u201cmolecular control knob\u201d that aids learning and memory - 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/pt\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/posts\/12175"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/comments?post=12175"}],"version-history":[{"count":1,"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/posts\/12175\/revisions"}],"predecessor-version":[{"id":12177,"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/posts\/12175\/revisions\/12177"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/media\/12176"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/media?parent=12175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/categories?post=12175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/pt\/wp-json\/wp\/v2\/tags?post=12175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}