{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pt\/coronavirus-covid-19-is-hydroxychloroquine-a-nova-ao-espera-para-sim\/","title":{"rendered":"Coronav\u00edrus (Covid-19): a hidroxicicloroquina \u00e9 a nova esperan\u00e7a? Aparentemente, sim."},"content":{"rendered":"

Dois artigos recentes resumiram uma pesquisa in vitro e um estudo cl\u00ednico em pequena escala foi suficiente para que Donald Trump fizesse com que a FDA aplicasse uma nova indica\u00e7\u00e3o cl\u00ednica de medicamentos para hidroxicloroquina: melhorar os sintomas do Coronav\u00edrus (Covid-19) - pacientes afetados.<\/p>\n

Este \u00e9 provavelmente o caminho mais r\u00e1pido de um processo de aprova\u00e7\u00e3o de medicamentos na hist\u00f3ria moderna, e o presidente est\u00e1 aparentemente certo. Surpreendente para um l\u00edder global que n\u00e3o tem muito carinho pela ci\u00eancia.<\/p>\n

\"\"<\/p>\n

As primeiras evid\u00eancias sobre a hidroxicloroquina no v\u00edrus vieram de este artigo publicado ontem sobre a Cell Discovery<\/a>\u00c9 apenas in vitro, com todas as limita\u00e7\u00f5es, mas mostra claramente o potencial da droga para matar o v\u00edrus. Quando apresentaram o documento, 80.000 casos foram confirmados na China, incluindo 2946 mortes, assim como mais de 10.566 casos confirmados em 72 outros pa\u00edses. Naquela \u00e9poca, a maior esperan\u00e7a foi depositada sobre uma droga chamada remdesivir.<\/p>\n

\"efeitos
Efeitos in vitro da hidrocloroquina sobre o coronav\u00edrus (Covid-19). A coluna \u00e0 direita mostra os efeitos do medicamento eficaz, em oposi\u00e7\u00e3o \u00e0 cloroquina ou ao grupo de controle \u00e0 esquerda. Isso mostra que o medicamento melhorou a capacidade das c\u00e9lulas de expelir os v\u00edrus... \u00e9 como ajudar a expulsar um vizinho indesejado de sua casa. Isso ajuda! \ud83d\ude42 <\/figcaption><\/figure>\n

Mas a maior not\u00edcia veio de um estudo cl\u00ednico em pequena escala publicado no dia anterior. O t\u00edtulo \u00e9 Hidroxicloroquina e azitromicina como tratamento da COVID-19: resultados de um ensaio cl\u00ednico aberto n\u00e3o randomizado e pode ser baixado em sua vers\u00e3o \"no prelo\".<\/a><\/p>\n

Em um estudo com apenas 20 pacientes, os autores mostraram que a hidroxicloroquina era eficaz contra a infec\u00e7\u00e3o pelo coronav\u00edrus Covid-19. De fato, reduziu 75% de indiv\u00edduos infectados no per\u00edodo de 6 dias, o que \u00e9 fant\u00e1stico. Ainda melhor que isso, a combina\u00e7\u00e3o com azitromicina melhorou a efic\u00e1cia do tratamento para 95%.<\/p>\n

\"A
A hidrohicloroquina e a azitromicina combinadas s\u00e3o eficazes novamente nas infec\u00e7\u00f5es por coronav\u00edrus (Covid-19) em pacientes humanos. A queda \u00e9 dram\u00e1tica e traz uma nova esperan\u00e7a para os pacientes afetados.<\/figcaption><\/figure>\n

O tratamento melhorou os sintomas, ao mesmo tempo em que reduziu a carga viral nos pacientes. O medicamento foi previamente aprovado para a mal\u00e1ria, o que significa que \u00e9 considerado seguro. O medicamento \"irm\u00e3\" cloroquina foi menos eficaz. Bom para n\u00f3s, porque \u00e9 algo mais t\u00f3xico.<\/p>\n

O estudo n\u00e3o foi randomizado e \u00e9 de pequena escala, entretanto, parece que enquanto a epidemia come\u00e7ou na China, a solu\u00e7\u00e3o vem de um esfor\u00e7o comunit\u00e1rio global. O papel in vitro \u00e9 na verdade chin\u00eas, enquanto o papel cl\u00ednico \u00e9 europeu, mais precisamente da Fran\u00e7a. Curiosamente, os registros originais de medicamentos para hidroxicloroquina s\u00e3o da empresa farmac\u00eautica francesa Sanofi, e o recente estudo cl\u00ednico foi realizado em Marselha. Ale le bleu!<\/p>\n

O Medscape tem um excelente artigo sobre o assunto, para aqueles interessados em informa\u00e7\u00f5es mais detalhadas.<\/a><\/p>\n

Cite este trabalho como Gautret et al. (2020) Hydroxychloroquine e azitromycin como tratamento da COVID-19: resultados de um ensaio cl\u00ednico n\u00e3o randomizado de marca aberta. International Journal of Antimicrobial Agents - In Press 17 de mar\u00e7o de 2020 - DOI : 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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