{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pl\/choroba-alzheimera\/","title":{"rendered":"Choroba Alzheimera: Infografika naukowa"},"content":{"rendered":"

Zawsze cieszymy si\u0119, gdy widzimy niesamowite prace naszych u\u017cytkownik\u00f3w.\u00a0Ju\u017c napisa\u0142em<\/a> o badaniach prowadzonych przez dr Alessandr\u0119 Martini, dr.\u00a0Stefania Forner<\/a>\u00a0i ich koledzy. S\u0105 oni badaczami podoktoranckimi na Uniwersytecie Kalifornijskim i uwa\u017caj\u0105 si\u0119 za u\u017cytkownik\u00f3w wykres\u00f3w. Kilka miesi\u0119cy temu pokaza\u0142em infografika<\/a>\u00a0Dr Stefania Forner stworzy\u0142a artyku\u0142 przegl\u0105dowy opublikowany w Trends in Neurosciences zatytu\u0142owany Synaptic impairment in Alzheimer's Disease: Rozregulowana symfonia.<\/p>\n

Dzi\u015b chc\u0119 porozmawia\u0107 o ich nowym artykule przegl\u0105dowym zatytu\u0142owanym Od przesz\u0142o\u015bci do przysz\u0142o\u015bci: czego modele zwierz\u0119ce nauczy\u0142y nas o chorobie Alzheimera.<\/a><\/p>\n

Choroba Alzheimera (AD) jest zaburzeniem neurodegeneracyjnym, kt\u00f3re powoduje deficyty poznawcze i utrat\u0119 pami\u0119ci. Zrozumienie mechanizmu choroby jest wa\u017cne dla poprawy jako\u015bci \u017cycia pacjent\u00f3w i znalezienia skutecznego leczenia. Obecnie, pomimo ogromnych wysi\u0142k\u00f3w ze strony \u015brodowiska akademickiego i przemys\u0142u farmaceutycznego, nie s\u0105 dost\u0119pne \u017cadne skuteczne metody leczenia. Choroba Alzheimera jest sz\u00f3st\u0105 najcz\u0119stsz\u0105 przyczyn\u0105 zgon\u00f3w w USA i dotyka 35 milion\u00f3w ludzi na ca\u0142ym \u015bwiecie.<\/p>\n

Infografiki dotycz\u0105ce choroby Alzheimera<\/h2>\n

 <\/p>\n

Wi\u0119kszo\u015b\u0107 pacjent\u00f3w z AD to osoby starsze, kt\u00f3re cz\u0119sto cierpi\u0105 na r\u00f3\u017cne choroby wsp\u00f3\u0142istniej\u0105ce. Cukrzyca, osteoporoza, choroby nerek, oty\u0142o\u015b\u0107, nadci\u015bnienie t\u0119tnicze i hipercholesterolemia\/dyslipidemia, udar m\u00f3zgu i drgawki s\u0105 g\u0142\u00f3wnymi chorobami wsp\u00f3\u0142istniej\u0105cymi wp\u0142ywaj\u0105cymi na pocz\u0105tek i progresj\u0119 AD, dodaj\u0105c zawi\u0142o\u015bci do patogenezy choroby.<\/p>\n

\"infografika
Infografika przedstawiaj\u0105ca choroby wsp\u00f3\u0142istniej\u0105ce w chorobie Alzheimera (AD). Przesz\u0142o\u015b\u0107 do przysz\u0142o\u015bci: Czego modele zwierz\u0119ce nauczy\u0142y nas o chorobie Alzheimera<\/figcaption><\/figure>\n

 <\/p>\n

\n

Pomimo intensywnych wysi\u0142k\u00f3w badawczych w ci\u0105gu ostatnich kilku dekad, mechanizmy le\u017c\u0105ce u podstaw etiologii sporadycznej AD (sAD), kt\u00f3ra stanowi najcz\u0119stsz\u0105 posta\u0107 choroby, pozostaj\u0105 nieznane. Wynika to, przynajmniej cz\u0119\u015bciowo, z faktu, \u017ce wi\u0119kszo\u015b\u0107 pacjent\u00f3w z sAD to osoby starsze, kt\u00f3re cz\u0119sto cierpi\u0105 na r\u00f3\u017cne choroby wsp\u00f3\u0142istniej\u0105ce (np. udar, stres, cukrzyca, drgawki, osteoporoza i choroby nerek)<\/em><\/p>\n<\/blockquote>\n

Kolejna infografika przedstawia powstawanie i mechanizmy toksyczno\u015bci synaptycznej oligomer\u00f3w tau i beta-amyloidu.<\/p>\n

 <\/p>\n

\"infografico
Od przesz\u0142o\u015bci do przysz\u0142o\u015bci: Czego modele zwierz\u0119ce nauczy\u0142y nas o chorobie Alzheimera?<\/figcaption><\/figure>\n

 <\/p>\n

\n

W przypadku tauopatii dochodzi do zmniejszenia liczby kolc\u00f3w dendrytycznych. Tau nie przedostaje si\u0119 do j\u0105dra neuronu, co powoduje uszkodzenie DNA. Zmniejsza si\u0119 liczba mitochondri\u00f3w, a tak\u017ce liczba p\u0119cherzyk\u00f3w presynaptycznych, co prowadzi do utraty synaptycznej. Taka utrata jest r\u00f3wnie\u017c spowodowana wej\u015bciem tau do dendryt\u00f3w i obszar\u00f3w postsynaptycznych. Tau agreguje r\u00f3wnie\u017c pozakom\u00f3rkowo, umo\u017cliwiaj\u0105c jego wychwytywanie przez inne neurony.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

Stworzy\u0142a r\u00f3wnie\u017c infografik\u0119, aby pokaza\u0107 mechanizmy zapalne zwi\u0105zane z chorob\u0105 Alzheimera (AD)<\/p>\n

 <\/p>\n

\"infografico<\/p>\n

 <\/p>\n

\n

W ci\u0105gu ostatnich kilku lat byli\u015bmy szczeg\u00f3lnie zainteresowani zrozumieniem, w jaki spos\u00f3b stan zapalny wp\u0142ywa na patologi\u0119 beta-amyloidu i tau. Osoby starsze s\u0105 podatne na infekcje wirusowe i bakteryjne, a te czynniki mikrobiologiczne mog\u0105 zaostrza\u0107 istniej\u0105cy stan zapalny w m\u00f3zgu, przyspieszaj\u0105c pogorszenie funkcji poznawczych.<\/em><\/p>\n<\/blockquote>\n

Gratulacje dr Stefania Forner za wspania\u0142\u0105 prac\u0119!<\/p>\n

Je\u015bli jeste\u015b naukowcem i chcesz tworzy\u0107 pi\u0119kne wykresy do swoich prac, mo\u017cesz ju\u017c teraz zosta\u0107 u\u017cytkownikiem mind the graph.<\/p>\n

\"untitled-creation63724<\/a><\/p>","protected":false},"excerpt":{"rendered":"

To zawsze \u015bwi\u0119to, gdy widzimy niesamowit\u0105 prac\u0119 naszych u\u017cytkownik\u00f3w. Pisa\u0142em ju\u017c o badaniach dr Alessandry Martini, dr Stefanii Forner i ich koleg\u00f3w. S\u0105 oni badaczami podoktoranckimi na Uniwersytecie Kalifornijskim i uwa\u017caj\u0105 si\u0119 za u\u017cytkownik\u00f3w wykres\u00f3w. Kilka miesi\u0119cy temu pokaza\u0142em infografik\u0119 stworzon\u0105 przez dr Stefani\u0119 Forner na potrzeby artyku\u0142u przegl\u0105dowego opublikowanego w Trends [...]<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/pl\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - 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