{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pl\/autofagia-wygrywa-nagrode-nobla-medycyna\/","title":{"rendered":"Autofagia zdobywa Nagrod\u0119 Nobla w dziedzinie medycyny"},"content":{"rendered":"

Proces autofagii jest zaanga\u017cowany w kilka schorze\u0144, takich jak rak i choroby neurologiczne. Dzia\u0142a on jako wewn\u0119trzny program recyklingu organizmu. Zaburzenia autofagii s\u0105 jednak powi\u0105zane z chorob\u0105 Parkinsona, cukrzyc\u0105, nowotworami i innymi zaburzeniami zwi\u0105zanymi z wiekiem.<\/p>\n

Po tym kr\u00f3tkim wst\u0119pie na temat znaczenia procesu autofagii, nie jest zaskoczeniem, \u017ce nowe odkrycia w tej dziedzinie mog\u0105 prowadzi\u0107 do Nagrody Nobla. Rzeczywi\u015bcie, w zesz\u0142y poniedzia\u0142ek badaczka Yoshino Ohsumi zdoby\u0142a nagrod\u0119 Nobla w kategorii Nagroda Nobla w dziedzinie medycyny<\/a> za identyfikacj\u0119 pierwszych gen\u00f3w niezb\u0119dnych dla autofagii.<\/p>\n

\"Nie czuj\u0119 si\u0119 komfortowo rywalizuj\u0105c z wieloma osobami, a zamiast tego uwa\u017cam, \u017ce przyjemniej jest robi\u0107 co\u015b, czego nikt inny nie robi. W pewnym sensie o to w\u0142a\u015bnie chodzi w nauce, a rado\u015b\u0107 z odkrycia czego\u015b mnie inspiruje\". Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Jak Ohsumi to zrobi\u0142?<\/h3>\n

W swoim laboratorium Ohsumi zaprojektowa\u0142 szczepy dro\u017cd\u017cy, kt\u00f3re gromadzi\u0142y autofagosomy podczas g\u0142odu. Akumulacja ta mog\u0142a nast\u0105pi\u0107 tylko wtedy, gdy geny niezb\u0119dne do autofagii by\u0142y nieaktywne. Ohsumi zacz\u0105\u0142 wi\u0119c manipulowa\u0107 kom\u00f3rkami, wprowadzaj\u0105c kilka mutacji gen\u00f3w i uda\u0142o mu si\u0119 wywo\u0142a\u0107 autofagi\u0119.<\/p>\n

\"Autofagia<\/a><\/p>\n

Autofagia jest ju\u017c znana<\/h3>\n

Mimo \u017ce autofagia jest znana od 50 lat, dopiero w latach 90. dzi\u0119ki badaniom Ohsumiego uznano znaczenie tego procesu.
\nZa swoj\u0105 prac\u0119 Ohsumi zyska\u0142 ju\u017c kilku fan\u00f3w:<\/p>\n

\"Autofagia<\/a><\/p>\n

\n

\"Jestem bardzo szcz\u0119\u015bliwy, \u017ce otrzyma\u0142 tegoroczn\u0105 nagrod\u0119 Nobla, jest ona bardzo zas\u0142u\u017cona. Jego laboratorium pracuje g\u0142\u00f3wnie na dro\u017cd\u017cach. Przeprowadzili wst\u0119pne badania przesiewowe, kt\u00f3re umo\u017cliwi\u0142y odkrycie kluczowych gen\u00f3w zaanga\u017cowanych w autofagi\u0119. Tak wiele innych laboratori\u00f3w wykorzysta\u0142o jego odkrycia, bezpo\u015brednio lub po\u015brednio, aby zobaczy\u0107, dlaczego jest to wa\u017cne w chorobach\".<\/p>\n

David Rubinsztein<\/a> - zast\u0119pca dyrektora Instytutu Bada\u0144 Medycznych w Cambridge<\/p>\n<\/blockquote>\n

\"Autofagia<\/a><\/p>\n

\n

\"My\u015bl\u0119, \u017ce to bardzo wa\u017cne, \u017ce ten obszar nauki zosta\u0142 doceniony. Wa\u017cn\u0105 zasad\u0105 jest tutaj poszukiwanie wsp\u00f3lnych mechanizm\u00f3w w chorobie. Otwiera to mo\u017cliwo\u015bci leczenia tych zaburze\u0144, kt\u00f3re r\u00f3\u017cni\u0105 si\u0119 od bardziej konwencjonalnych podej\u015b\u0107 specyficznych dla danej choroby\".<\/p>\n

Giovanna Mallucci<\/a> - profesor neuronauki klinicznej na Uniwersytecie w Cambridge<\/p>\n<\/blockquote>\n

\"Autofagia<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Proces autofagii jest zaanga\u017cowany w kilka schorze\u0144, takich jak rak i choroby neurologiczne. Dzia\u0142a on jako wewn\u0119trzny program recyklingu organizmu. Zaburzenia autofagii s\u0105 jednak powi\u0105zane z chorob\u0105 Parkinsona, cukrzyc\u0105, nowotworami i innymi zaburzeniami zwi\u0105zanymi z wiekiem. Po tym kr\u00f3tkim wprowadzeniu na temat znaczenia procesu autofagii, nie jest zaskoczeniem, \u017ce nowe odkrycia [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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