{"id":16657,"date":"2022-09-14T13:04:15","date_gmt":"2022-09-14T16:04:15","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16657"},"modified":"2023-03-17T14:47:26","modified_gmt":"2023-03-17T17:47:26","slug":"success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pl\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/","title":{"rendered":"XTALKDB: baza danych powi\u0105za\u0144 szlak\u00f3w sygna\u0142owych Przegl\u0105d artyku\u0142\u00f3w"},"content":{"rendered":"

Ten niesamowity artyku\u0142 przedstawia statystyki podsumowuj\u0105ce dane w XTALKDB. W zaledwie kilka minut autor stworzy\u0142 infografik\u0119 wyja\u015bniaj\u0105c\u0105 rozmieszczenie gatunk\u00f3w w XTALKDB.<\/p>\n\n\n\n

Sprawd\u017a oryginalny artyku\u0142 tutaj<\/a>.<\/p>\n\n\n\n

Poniewa\u017c ludzie s\u0105 istotami wizualnymi, obrazy s\u0105 nadal najlepszym sposobem na wyja\u015bnienie swoich bada\u0144 z dowoln\u0105 ilo\u015bci\u0105 szczeg\u00f3\u0142\u00f3w.<\/p>\n\n\n\n

Naukowcy opracowali baz\u0119 danych, kt\u00f3ra dokumentuje przes\u0142uch mi\u0119dzy okre\u015blonymi parami szlak\u00f3w sygna\u0142owych oraz gatunkami i tkankami, w kt\u00f3rych s\u0105 one obserwowane<\/strong><\/h2>\n\n\n\n

Grupa badawcza kierowana przez Sarah Sam z Wydzia\u0142u Nauk Biologicznych (2016) poinformowa\u0142a, \u017ce percepcja sygna\u0142u zewn\u0119trznego przez receptory powoduje zmian\u0119 aktywno\u015bci bia\u0142ek po\u015brednich. <\/p>\n\n\n\n

Skutkuje to regulacj\u0105 czynnik\u00f3w transkrypcyjnych, kt\u00f3re moduluj\u0105 ekspresj\u0119 gen\u00f3w docelowych. Dla ka\u017cdej pary \u015bcie\u017cek XTalkDB rejestruje szczeg\u00f3\u0142owe informacje opisuj\u0105ce warunki eksperymentalne, w kt\u00f3rych odkryto przes\u0142uch. <\/p>\n\n\n\n

Kom\u00f3rki oceniaj\u0105 swoje \u015brodowisko i reaguj\u0105 na nie poprzez szlaki sygna\u0142owe. Szlak sygnalizacyjny zazwyczaj zawiera dobrze zdefiniowany zestaw regulacyjnych i fizycznych interakcji mi\u0119dzy receptorami, po\u015brednimi bia\u0142kami sygnalizacyjnymi, czynnikami transkrypcyjnymi i genami docelowymi. <\/p>\n\n\n\n

Strona internetowa XTalkDB zapewnia \u0142atwy w u\u017cyciu interfejs dla naukowc\u00f3w do przegl\u0105dania informacji o przes\u0142uchach poprzez wyszukiwanie jednej lub wi\u0119cej \u015bcie\u017cek lub cz\u0105steczek b\u0119d\u0105cych przedmiotem zainteresowania.<\/p>\n\n\n\n

W badaniu wzi\u0119\u0142o udzia\u0142 650 par.<\/strong><\/p>\n\n\n\n

Abstrakcja graficzna obs\u0142ugiwana przez Mind the Graph<\/strong><\/h2>\n\n\n
\n
\"success-case-XTALKDB-a-database-of-signaling-pathway-crosstalk\"<\/a>
Wykonane z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Omawiaj\u0105c mo\u017cliwe ulepszenia, \"R\u0119czny proces kuratorski le\u017c\u0105cy u podstaw XTalkDB ma swoje ograniczenia, zw\u0142aszcza gdy staramy si\u0119 rozszerzy\u0107 zasi\u0119g bazy danych. <\/p>\n\n\n\n

Planujemy opracowa\u0107 struktur\u0119 przetwarzania j\u0119zyka naturalnego, kt\u00f3ra b\u0119dzie ocenia\u0107 publikacje na podstawie prawdopodobie\u0144stwa udokumentowania przes\u0142uch\u00f3w. Kurator mo\u017ce nast\u0119pnie skupi\u0107 si\u0119 na wysoko ocenionych publikacjach\" - przyznaj\u0105.<\/p>\n\n\n\n

Dokumenty Wp\u0142yw i wydajno\u015b\u0107<\/strong><\/h2>\n\n\n\n

Mo\u017cemy analizowa\u0107 za pomoc\u0105 Altmetric<\/a> dane, \u017ce ten artyku\u0142 jest na g\u00f3rna cz\u0119\u015b\u0107 wszystkich wska\u017anik\u00f3w we wszystkich artyku\u0142ach finansowanych przez NIH w Dimensions. <\/strong><\/p>\n\n\n

\n
\"\"<\/a>
\u0179r\u00f3d\u0142o: https:\/\/badge.dimensions.ai\/details\/id\/pub.1052462103<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Wykorzystaj moc infografiki, aby wzmocni\u0107 sw\u00f3j artyku\u0142. Wypr\u00f3buj Mind the Graph!<\/p>\n\n\n\n

<\/div>\n\n\n\n
\n
Wypr\u00f3buj Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Ucz si\u0119 z tymi, kt\u00f3rzy ju\u017c odkryli moc infografik. Ten artyku\u0142 zawiera graficzne streszczenia wykonane za pomoc\u0105 Mind the Graph. <\/p>","protected":false},"author":29,"featured_media":20046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"\nXTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/pl\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"XTALKDB: a database of signaling pathway crosstalk Paper Review - 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