{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pl\/sukces-przypadek-synchrotronowej-mikrotomografii-rentgenowskiej-wysokiej-rozdzielczosci-jako-narzedzia-odslaniajacego-trojwymiarowa-neuronalna-architekture-mozgu\/","title":{"rendered":"Synchrotronowa mikrotomografia rentgenowska o wysokiej rozdzielczo\u015bci jako narz\u0119dzie do odkrywania tr\u00f3jwymiarowej architektury neuronalnej m\u00f3zgu Paper Review"},"content":{"rendered":"

Mikrotomografia rentgenowska pojawi\u0142a si\u0119 jako nowa metoda rozszyfrowywania cytoarchitektury i po\u0142\u0105cze\u0144 m\u00f3zgu, a tutaj przedstawiamy metod\u0119 obrazowania ca\u0142ych neuron\u00f3w.<\/p>\n\n\n\n

Synchrotronowa mikrotomografia rentgenowska o wysokiej rozdzielczo\u015bci jako narz\u0119dzie do odkrywania tr\u00f3jwymiarowej architektury neuronalnej m\u00f3zgu<\/strong><\/h2>\n\n\n\n

W artykule \"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain\", Matheus de Castro Fonseca et al. (2018) zauwa\u017cyli, \u017ce badanie neuron\u00f3w jako zindywidualizowanych jedno\u015bci ma sw\u00f3j pocz\u0105tek w XIX wieku wraz z powstaniem Doktryny Neuron\u00f3w. <\/p>\n\n\n\n

W ci\u0105gu ostatnich kilku lat podj\u0119to ogromne wysi\u0142ki w celu zrozumienia organizacji neuron\u00f3w i po\u0142\u0105cze\u0144 w nienaruszonych pr\u00f3bkach m\u00f3zgu. Technika znakowania Golgiego-Coxa oferuje odpowiedni kontrast do specyficznego znakowania neuron\u00f3w dla mikrotomografii rentgenowskiej. <\/p>\n\n\n\n

Neurony maj\u0105 wyra\u017an\u0105 morfologi\u0119 i specyficzne wzorce po\u0142\u0105cze\u0144, kt\u00f3re s\u0105 niezb\u0119dne do ich prawid\u0142owego funkcjonowania. Naukowcy przedstawiaj\u0105 metod\u0119 obrazowania \u0142\u0105cz\u0105c\u0105 mikrotomografi\u0119 rentgenowsk\u0105 opart\u0105 na synchrotronie z protoko\u0142em impregnacji Golgiego-Coxa. <\/p>\n\n\n\n

Metoda ta zapewnia wy\u017cszy i bardziej jednorodny kontrast stosunkowo s\u0142abo rozmieszczonych ca\u0142ych neuron\u00f3w w tkance.<\/p>\n\n\n\n

M\u00f3zgi inkubowano w roztworze barwi\u0105cym Golgiego-Coxa przez 14 dni, chroni\u0105c przed \u015bwiat\u0142em. Po okresie inkubacji m\u00f3zgi seryjnie skrawano przy u\u017cyciu wibratomu.<\/strong><\/p>\n\n\n\n

Sprawd\u017a oryginalny artyku\u0142 tutaj<\/a>.<\/p>\n\n\n\n

Abstrakcja graficzna obs\u0142ugiwana przez Mind the Graph<\/strong><\/h2>\n\n\n\n
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Wykonane z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Autor u\u017cy\u0142 Mind the Graph<\/a> aby stworzy\u0107 schematyczn\u0105 ilustracj\u0119 przedstawiaj\u0105c\u0105 doros\u0142\u0105 mysz, kt\u00f3rej wstrzykni\u0119to s\u00f3l fizjologiczn\u0105 lub roztw\u00f3r pilokarpiny (280 mg\/kg). Przedstawienie z\u0142o\u017conych proces\u00f3w za pomoc\u0105 infografiki jest dobrym sposobem na ich \u0142atwe zrozumienie, bez pomijania szczeg\u00f3\u0142\u00f3w i kluczowych informacji.<\/p>\n\n\n\n

Niekt\u00f3re z wynik\u00f3w uzyskanych przez naukowc\u00f3w wydaj\u0105 si\u0119 potwierdza\u0107 to, co wcze\u015bniej by\u0142o wiadomo na ten temat: \"Pokazana tutaj impregnacja neuron\u00f3w na bazie rt\u0119ci pozwoli\u0142a nam wyra\u017anie zdefiniowa\u0107 ca\u0142e neurony, g\u0142\u00f3wnie ze wzgl\u0119du na bardziej ci\u0105g\u0142\u0105 i jednorodn\u0105 impregnacj\u0119 kom\u00f3rek oraz znacznie zmniejszon\u0105 g\u0119sto\u015b\u0107 artefakt\u00f3w\" - zasugerowa\u0142 de Castro Fonseca.<\/p>\n\n\n\n

Dokumenty Wp\u0142yw i wydajno\u015b\u0107<\/strong><\/h2>\n\n\n\n

Mo\u017cemy analizowa\u0107 za pomoc\u0105 Altmetric<\/a> dane, \u017ce wynik uwagi online tego artyku\u0142u jest wy\u017cszy ni\u017c 64%<\/strong><\/strong> wszystkich innych artyku\u0142\u00f3w w podobnym wieku w czasopi\u015bmie Scientific Reports.<\/strong><\/p>\n\n\n\n

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\u0179r\u00f3d\u0142o Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Popraw tak\u017ce dost\u0119pno\u015b\u0107 swojego artyku\u0142u dzi\u0119ki infografikom.<\/p>\n\n\n\n

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Wypr\u00f3buj Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Zapoznaj si\u0119 z now\u0105 metod\u0105 rozszyfrowywania cytoarchitektury i po\u0142\u0105cze\u0144 m\u00f3zgu przedstawionych na ilustracjach Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/pl\/sukces-przypadek-synchrotronowej-mikrotomografii-rentgenowskiej-wysokiej-rozdzielczosci-jako-narzedzia-odslaniajacego-trojwymiarowa-neuronalna-architekture-mozgu\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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