{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pl\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"Wirus Zika replikuje si\u0119 w tkance m\u00f3zgowej doros\u0142ych ludzi i upo\u015bledza synapsy i pami\u0119\u0107 u myszy Paper Review"},"content":{"rendered":"

ZIKV to niebezpieczny wirus, kt\u00f3ry pustoszy \u015bwiat. Dlatego w tym przypadku autor bada jego replikacj\u0119 w m\u00f3zgu doros\u0142ego cz\u0142owieka.<\/p>\n\n\n\n

Wirus Zika (ZIKV) infekuje tkank\u0119 m\u00f3zgow\u0105 doros\u0142ych i powoduje zaburzenia pami\u0119ci u myszy<\/strong><\/h2>\n\n\n\n

Grupa ze School of Pharmacy kierowana przez Claudi\u0119 Figueiredo (2019) bada\u0142a, w jaki spos\u00f3b wirus Zika replikuje si\u0119 w tkance m\u00f3zgowej doros\u0142ego cz\u0142owieka oraz upo\u015bledza synapsy i pami\u0119\u0107 u myszy. Wirus Zika to arbowirus nale\u017c\u0105cy do rodziny Flaviviridae, odpowiedzialny za niedawny powa\u017cny wybuch epidemii w Ameryce \u0141aci\u0144skiej. <\/p>\n\n\n\n

ZIKV wykryto w m\u00f3zgach i p\u0142ynie m\u00f3zgowo-rdzeniowym doros\u0142ych pacjent\u00f3w. Immunoreaktywno\u015b\u0107 NS2B kolokalizowa\u0142a si\u0119 z kom\u00f3rkami immunoreaktywnymi NeuN, ale nie z GFAP lub F4\/80, wskazuj\u0105c, \u017ce neurony s\u0105 celem ZIKV w dojrza\u0142ej tkance ludzkiej. U doros\u0142ych immunokompetentnych myszy zaka\u017conych przez infuzj\u0119 dokomorow\u0105 ZIKV, wysokie poziomy RNA ZikV s\u0105 wykrywane w korze czo\u0142owej i hipokampie, a dojrza\u0142e neurony s\u0105 g\u0142\u00f3wnym typem zaka\u017conych kom\u00f3rek. <\/p>\n\n\n\n

Zweryfikowano podwy\u017cszony poziom TNF-\u03b1 w m\u00f3zgu, intensywn\u0105 mikroglejoz\u0119, zwi\u0119kszon\u0105 ekspresj\u0119 bia\u0142ek uk\u0142adu dope\u0142niacza (C1q i C3) oraz uszkodzenie synaps hipokampa.<\/p>\n\n\n\n

Badanie obejmowa\u0142o 9 r\u00f3wnych kwadrant\u00f3w.<\/strong><\/p>\n\n\n\n

Sprawd\u017a oryginalny artyku\u0142 tutaj<\/a>.<\/p>\n\n\n\n

Abstrakcje graficzne obs\u0142ugiwane przez Mind the Graph<\/strong><\/h2>\n\n\n\n
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Wykonane z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Pierwszy rysunek przedstawia przypadek, w kt\u00f3rym fragmenty tkanki kory ludzkiego p\u0142ata skroniowego zosta\u0142y poci\u0119te na plastry o grubo\u015bci 400 \u00b5m i utrzymywane w hodowli przez 4 dni przed inkubacj\u0105 z ZIKV (107 PFU) lub po\u017cywk\u0105 mock przez 1 godzin\u0119, a nast\u0119pnie wyp\u0142ukane. <\/p>\n\n\n\n

<\/div>\n\n\n
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Wykonane z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Drugi pokazuje, \u017ce doros\u0142e myszy otrzyma\u0142y infuzj\u0119 105 PFU ZIKV, ZIKV inaktywowanego promieniowaniem UV lub po\u017cywki mock do bocznej komory m\u00f3zgu.<\/p>\n\n\n\n

Wnioski wydaj\u0105 si\u0119 potwierdza\u0107 to, co wcze\u015bniej by\u0142o wiadomo na ten temat: \"ZIKV atakuje regiony m\u00f3zgu zwi\u0105zane z pami\u0119ci\u0105, niezale\u017cnie od tego, czy droga zaka\u017cenia jest centralna czy obwodowa. Wirus zosta\u0142 wykryty w p\u0142ynie m\u00f3zgowo-rdzeniowym doros\u0142ych pacjent\u00f3w z powik\u0142aniami neurologicznymi\" - twierdzi Figueiredo.<\/p>\n\n\n\n

Proponuj\u0105 oni, aby przysz\u0142e badania maj\u0105ce na celu zbadanie d\u0142ugoterminowego neurodegeneracyjnego wp\u0142ywu zaka\u017cenia ZIKV by\u0142y uzasadnione. Identyfikacja sposob\u00f3w zapobiegania nieprawid\u0142owo\u015bciom sygnalizacyjnym prowadz\u0105cym do dysfunkcji m\u00f3zgu mo\u017ce utorowa\u0107 drog\u0119 do strategii interwencyjnych maj\u0105cych na celu op\u00f3\u017anienie lub zapobieganie rozwojowi powa\u017cnych schorze\u0144 neurologicznych.<\/p>\n\n\n\n

Dokumenty Wp\u0142yw i wydajno\u015b\u0107<\/strong><\/h2>\n\n\n\n

Mo\u017cemy analizowa\u0107 za pomoc\u0105 Altmetric<\/a> dane, \u017ce wynik uwagi online tego artyku\u0142u jest wy\u017cszy ni\u017c 95%<\/strong><\/strong> wszystkich innych artyku\u0142\u00f3w w podobnym wieku w Nature<\/strong> Czasopisma.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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\u0179r\u00f3d\u0142o Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Wykorzystaj moc infografiki, aby wzmocni\u0107 sw\u00f3j artyku\u0142! Rozpocznij tworzenie w Mind the Graph.<\/p>\n\n\n\n

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Wypr\u00f3buj Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Badanie dotyczy ZIKV w m\u00f3zgu doros\u0142ego cz\u0142owieka, niebezpiecznego wirusa, kt\u00f3ry pustoszy \u015bwiat. Proces wykorzystuje ilustracje Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/pl\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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