{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/pl\/coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes\/","title":{"rendered":"Koronawirus (Covid-19): czy hydroksychlorochina jest now\u0105 nadziej\u0105? Najwyra\u017aniej tak."},"content":{"rendered":"

Dwa ostatnie artyku\u0142y podsumowuj\u0105ce jedno badanie in vitro i badanie kliniczne na ma\u0142\u0105 skal\u0119 wystarczy\u0142y, aby Donald Trump zmusi\u0142 FDA do wprowadzenia nowego wskazania klinicznego dla hydroksychlorochiny: z\u0142agodzenia objaw\u00f3w u pacjent\u00f3w dotkni\u0119tych koronawirusem (Covid-19).<\/p>\n

Jest to prawdopodobnie najszybszy proces zatwierdzania lek\u00f3w we wsp\u00f3\u0142czesnej historii, a prezydent najwyra\u017aniej ma racj\u0119. Zaskakuj\u0105ce jak na \u015bwiatowego lidera, kt\u00f3ry nie darzy nauki zbytni\u0105 sympati\u0105.<\/p>\n

\"\"<\/p>\n

Pierwsze dowody na dzia\u0142anie hydroksychlorochiny na wirusa pochodz\u0105 od artyku\u0142 opublikowany wczoraj w Cell Discovery<\/a>To tylko in vitro, ze wszystkimi ograniczeniami, ale wyra\u017anie pokazuje potencja\u0142 leku do zabijania wirusa. W momencie z\u0142o\u017cenia pracy potwierdzono 80 000 przypadk\u00f3w w Chinach, w tym 2946 zgon\u00f3w, a tak\u017ce ponad 10 566 potwierdzonych przypadk\u00f3w w 72 innych krajach. W tym czasie najwi\u0119ksze nadzieje pok\u0142adano w leku o nazwie remdesivir.<\/p>\n

\"Wp\u0142yw
Wp\u0142yw hydrochlorochiny na koronawirusa (Covid-19) in vitro. Kolumna po prawej stronie pokazuje dzia\u0142anie skutecznego leku, w przeciwie\u0144stwie do chlorochiny lub grupy kontrolnej po lewej stronie. Pokazuje to, \u017ce lek poprawi\u0142 zdolno\u015b\u0107 kom\u00f3rek do wydalania wirus\u00f3w... to tak, jakby pom\u00f3c wyrzuci\u0107 niechcianego s\u0105siada z domu. To pomaga! \ud83d\ude42 <\/figcaption><\/figure>\n

Jednak naj\u015bwie\u017csze informacje pochodz\u0105 z niewielkiego badania klinicznego opublikowanego dzie\u0144 wcze\u015bniej. Jego tytu\u0142 to Hydroksychlorochina i azytromycyna w leczeniu COVID-19: wyniki otwartego nierandomizowanego badania klinicznego, kt\u00f3re mo\u017cna pobra\u0107 w wersji \"in press\".<\/a><\/p>\n

W badaniu z udzia\u0142em zaledwie 20 pacjent\u00f3w autorzy wykazali, \u017ce hydroksychlorochina by\u0142a skuteczna przeciwko zaka\u017ceniu koronawirusem Covid-19. W rzeczywisto\u015bci zmniejszy\u0142a 75% zaka\u017conych os\u00f3b w okresie 6 dni, co jest niesamowite. Co wi\u0119cej, po\u0142\u0105czenie z azytromycyn\u0105 zwi\u0119kszy\u0142o skuteczno\u015b\u0107 leczenia do 95%.<\/p>\n

\"Terapia
Terapia skojarzona hydrochlorochin\u0105 i azytromycyn\u0105 jest skuteczna w zwalczaniu zaka\u017ce\u0144 koronawirusem (Covid-19) u ludzi. Spadek jest dramatyczny i przynosi now\u0105 nadziej\u0119 dotkni\u0119tym pacjentom.<\/figcaption><\/figure>\n

Leczenie z\u0142agodzi\u0142o objawy, a tak\u017ce zmniejszy\u0142o miano wirusa u pacjent\u00f3w. Lek zosta\u0142 wcze\u015bniej zatwierdzony do stosowania w leczeniu malarii, co oznacza, \u017ce jest uwa\u017cany za bezpieczny. \"Siostrzany\" lek, chlorochina, by\u0142 mniej skuteczny. To dobrze dla nas, poniewa\u017c jest ona bardziej toksyczna.<\/p>\n

Badanie by\u0142o nierandomizowane i przeprowadzone na ma\u0142\u0105 skal\u0119, jednak wydaje si\u0119, \u017ce chocia\u017c epidemia rozpocz\u0119\u0142a si\u0119 w Chinach, rozwi\u0105zanie pochodzi z globalnego wysi\u0142ku spo\u0142eczno\u015bci. Artyku\u0142 in vitro jest w rzeczywisto\u015bci chi\u0144ski, podczas gdy kliniczny jest europejski, a dok\u0142adniej z Francji. Co ciekawe, oryginalna rejestracja hydroksychlorochiny pochodzi od francuskiej firmy farmaceutycznej Sanofi, a ostatnie badanie kliniczne zosta\u0142o przeprowadzone w Marsylii. Ale le bleu!<\/p>\n

Medscape ma doskona\u0142y artyku\u0142 na ten temat dla os\u00f3b zainteresowanych bardziej szczeg\u00f3\u0142owymi informacjami.<\/a><\/p>\n

Prosimy o cytowanie tej pracy jako Gautret et al. (2020) Hydroksychlorochina i azytromycyna w leczeniu COVID-19: wyniki otwartego nierandomizowanego badania klinicznego. International Journal of Antimicrobial Agents - W druku 17 marca 2020 r. - DOI : 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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