{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nl\/autofagie-wint-nobel-prijs-medicijn\/","title":{"rendered":"Autofagie wint Nobelprijs voor geneeskunde"},"content":{"rendered":"

Het autofagieproces is betrokken bij verschillende aandoeningen zoals kanker en neurologische ziekten. Het werkt als het interne recyclingprogramma van het lichaam. Disfunctionele autofagie is echter in verband gebracht met de ziekte van Parkinson, diabetes, cances en andere leeftijdsgebonden aandoeningen.<\/p>\n

Na deze kleine inleiding over het belang van het autofagieproces is het geen verrassing dat nieuwe ontdekkingen op dit gebied kunnen leiden tot een Nobelprijs. Inderdaad, afgelopen maandag won de onderzoeker Yoshino Ohsumi de Nobelprijs voor geneeskunde<\/a> voor het identificeren van de eerste essenti\u00eble genen voor autofagie.<\/p>\n

\"Ik voel me niet op mijn gemak om met veel mensen te concurreren, en in plaats daarvan vind ik het leuker om iets te doen wat niemand anders doet. In zekere zin is dat waar wetenschap om draait, en het plezier om iets te vinden inspireert me.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Hoe heeft Ohsumi het gedaan?<\/h3>\n

In zijn lab had Ohsumi giststammen ontworpen die autofagosomen opstapelden tijdens verhongering. Deze accumulatie kon alleen gebeuren als essenti\u00eble genen voor autofagie inactief waren. Dus begon Ohsumi de cellen te manipuleren met verschillende genmutaties en slaagde erin autofagie te induceren.<\/p>\n

\"Autofagie<\/a><\/p>\n

Autofagie bestaat al langer<\/h3>\n

Hoewel autofagie al 50 jaar bekend is, werd het belang van dit proces pas in de jaren negentig erkend in de studies van Ohsumi.
\nVoor zijn werk verdiende Ohsumi al enkele fans:<\/p>\n

\"Autofagie<\/a><\/p>\n

\n

\"Ik ben erg blij dat hij dit jaar de Nobelprijs heeft gekregen, het is zeer verdiend. Zijn lab werkt voornamelijk in gist. Zij deden de eerste onderzoeken die de ontdekking mogelijk maakten van belangrijke genen die betrokken zijn bij autofagie. Veel andere laboratoria hebben zijn ontdekkingen benut, direct of indirect, om te zien waarom het belangrijk is bij ziekten.\"<\/p>\n

David Rubinsztein<\/a> - adjunct-directeur van het Cambridge Instituut voor Medisch Onderzoek<\/p>\n<\/blockquote>\n

\"Autofagie<\/a><\/p>\n

\n

\"Ik denk dat het heel belangrijk is dat dit gebied van de wetenschap wordt erkend. Het belangrijke principe hier is het zoeken naar gemeenschappelijke mechanismen bij ziekte. Het opent wegen voor de behandeling van deze aandoeningen die anders zijn dan de meer conventionele ziektespecifieke benaderingen.\"<\/p>\n

Giovanna Mallucci<\/a> - hoogleraar klinische neurowetenschappen aan de Universiteit van Cambridge<\/p>\n<\/blockquote>\n

\"Autofagie<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Het autofagieproces is betrokken bij verschillende aandoeningen zoals kanker en neurologische ziekten. Het werkt als het interne recyclingprogramma van het lichaam. Disfunctionele autofagie is echter in verband gebracht met de ziekte van Parkinson, diabetes, cances en andere leeftijdsgebonden aandoeningen. Na deze kleine inleiding over het belang van het autofagieproces is het geen verrassing dat nieuwe ontdekkingen [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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