{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nl\/succes-case-hoge-resolutie-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/","title":{"rendered":"Hoge-resolutie synchrotron-gebaseerde X-ray microtomografie als een instrument om de driedimensionale neuronale architectuur van de hersenen te onthullen Paper Review"},"content":{"rendered":"

R\u00f6ntgenmicrotomografie is uitgegroeid tot een nieuwe methode om de cytoarchitectuur en de connectiviteit van de hersenen te ontcijferen, en hier presenteren wij een methode voor beeldvorming van hele neuronen.<\/p>\n\n\n\n

Hoge-resolutie synchrotron-gebaseerde r\u00f6ntgen microtomografie als hulpmiddel om de driedimensionale neuronale architectuur van de hersenen te onthullen.<\/strong><\/h2>\n\n\n\n

In 'High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain' merkten Matheus de Castro Fonseca et al. (2018) op dat de studie van neuronen als ge\u00efndividualiseerde eenheden zijn begin heeft in de 19e eeuw met het ontstaan van de Neuron Doctrine. <\/p>\n\n\n\n

De laatste jaren zijn grote inspanningen geleverd om de neuronale organisatie en connectiviteit in intacte hersenmonsters te begrijpen. De Golgi-Cox labelingtechniek biedt een geschikt contrast voor de specifieke labeling van neuronen voor r\u00f6ntgenmicrotomografie. <\/p>\n\n\n\n

Neuronen hebben een uitgesproken morfologie en specifieke verbindingspatronen, die essentieel zijn voor hun goede werking. De onderzoekers presenteren een beeldvormingsmethode die synchrotron-gebaseerde r\u00f6ntgenmicrotomografie combineert met het Golgi-Cox impregnatieprotocol. <\/p>\n\n\n\n

De methode biedt een hoger en homogener contrast van relatief schaars verdeelde hele neuronen in het weefsel.<\/p>\n\n\n\n

De hersenen werden gedurende 14 dagen ge\u00efncubeerd in Golgi-Cox-kleuroplossing, beschermd tegen licht. Na de incubatieperiode werden de hersenen in serie gesneden met een vibratoom.<\/strong><\/p>\n\n\n\n

Controleer de origineel artikel hier<\/a>.<\/p>\n\n\n\n

Grafisch Abstract aangedreven door Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Gemaakt met Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

De auteur gebruikte Mind the Graph<\/a> om een schematische illustratie te maken van een volwassen muis die i.p. wordt ingespoten met een zoutoplossing of een pilocarpine-oplossing (280 mg\/kg). Complexe processen weergeven met infographics is een goede manier om ze begrijpelijk te maken, zonder de details en cruciale informatie weg te laten.<\/p>\n\n\n\n

Sommige resultaten van de onderzoekers lijken te consolideren wat eerder over dit gebied bekend was: \"De hier getoonde impregnering met kwik van neuronen stelde ons in staat hele neuronen duidelijk te defini\u00ebren, voornamelijk vanwege een meer continue en homogene impregnering van de cellen en een veel geringere dichtheid van artefacten,\" stelde de Castro Fonseca.<\/p>\n\n\n\n

Documenten Impact en prestaties<\/strong><\/h2>\n\n\n\n

We kunnen analyseren met Altmetric<\/a> gegevens dat de online aandachtsscore van deze krant hoger is... dan 64%<\/strong><\/strong> van alle andere artikelen van dezelfde leeftijd in Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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Bron Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Verbeter ook de toegankelijkheid van uw artikel met de kracht van infographics.<\/p>\n\n\n\n

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Probeer Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Kijk naar de nieuwe methode om de cytoarchitectuur en connectiviteit van de hersenen te ontcijferen, weergegeven met de illustraties van Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/nl\/succes-case-hoge-resolutie-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/\" \/>\n<meta property=\"og:locale\" content=\"nl_NL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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