{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nl\/succes-case-zika-virus-repliceert-in-volwassen-menselijk-hersenweefsel-en-schaadt-synapsen-en-geheugen-in-muizen\/","title":{"rendered":"Zika-virus vermenigvuldigt zich in volwassen menselijk hersenweefsel en beschadigt synapsen en geheugen bij muizen Paper Review"},"content":{"rendered":"

ZIKV is een gevaarlijk virus dat de wereld teistert. Daarom bestudeert de auteur in dit geval de replicatie ervan in de volwassen menselijke hersenen.<\/p>\n\n\n\n

Zika-virus (ZIKV) infecteert volwassen hersenweefsel en veroorzaakt geheugenverlies bij muizen<\/strong><\/h2>\n\n\n\n

Een groep van de School of Pharmacy onder leiding van Claudia Figueiredo (2019) onderzocht hoe het zika-virus zich vermenigvuldigt in volwassen menselijk hersenweefsel en de synapsen en het geheugen in muizen aantast. Zika virus is een arbovirus dat behoort tot de Flaviviridae familie die verantwoordelijk is voor een recente grote uitbraak in Latijns-Amerika. <\/p>\n\n\n\n

ZIKV is aangetroffen in de hersenen en de liquor van volwassen pati\u00ebnten. NS2B-immunoreactiviteit colokaliseerde met NeuN-immunoreactieve cellen, maar niet met GFAP of F4\/80, wat erop wijst dat neuronen het doelwit zijn van ZikV in het volwassen menselijke weefsel. In volwassen immunocompetente muizen die ge\u00efnfecteerd zijn door intracerebroventriculaire infusie van ZIKV, worden hoge niveaus van ZikV RNA gedetecteerd in de frontale cortex en de hippocampus, en volwassen neuronen zijn het belangrijkste celtype dat ge\u00efnfecteerd is. <\/p>\n\n\n\n

Verhoogde niveaus van TNF-\u03b1 in de hersenen, intense microgliosis, verhoogde expressie van eiwitten van het complementsysteem (C1q en C3), en schade aan de hippocampale synaps worden geverifieerd.<\/p>\n\n\n\n

Het onderzoek betrof 9 gelijke kwadranten.<\/strong><\/p>\n\n\n\n

Controleer de origineel artikel hier<\/a>.<\/p>\n\n\n\n

Grafische samenvattingen aangedreven door Mind the Graph<\/strong><\/h2>\n\n\n\n
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Gemaakt met Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

De eerste figuur geeft het geval weer waarbij de menselijke temporale kwab corticale weefselfragmenten in plakjes van 400 \u00b5m werden gesneden en gedurende 4 dagen in cultuur werden gehouden voorafgaand aan incubatie met ZIKV (107 PFU) of mock medium gedurende 1 uur, gevolgd door uitwassen. <\/p>\n\n\n\n

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Gemaakt met Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

De tweede laat zien dat volwassen muizen een infusie kregen van 105 PFU ZIKV, UV-ge\u00efnactiveerd ZIKV of schijnmedium in de cerebrale laterale ventrikel.<\/p>\n\n\n\n

De conclusies lijken te bevestigen wat eerder over dit onderwerp bekend was: \"ZIKV richt zich op geheugengerelateerde hersengebieden, ongeacht of de infectieroute centraal of perifeer is. Het virus is gedetecteerd in CSF van volwassen pati\u00ebnten met neurologische complicaties\", aldus Figueiredo.<\/p>\n\n\n\n

Zij stellen voor dat toekomstige studies gericht op het onderzoeken van de neurodegeneratieve gevolgen op lange termijn van ZIKV-infectie gerechtvaardigd zijn. Het identificeren van manieren om signaalafwijkingen die leiden tot hersendisfunctie te voorkomen, zou de weg kunnen banen voor interventiestrategie\u00ebn om de ontwikkeling van ernstige neurologische aandoeningen uit te stellen of te voorkomen.<\/p>\n\n\n\n

Documenten Impact en prestaties<\/strong><\/h2>\n\n\n\n

We kunnen analyseren met Altmetric<\/a> gegevens dat de online aandachtsscore van deze krant hoger is... dan 95%<\/strong><\/strong> van alle andere artikelen van een vergelijkbare leeftijd in de Natuur<\/strong> Tijdschriften.<\/strong><\/p>\n\n\n\n

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Bron Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Gebruik de kracht van infographics ook om je artikel een boost te geven! Start een creatie bij Mind the Graph.<\/p>\n\n\n\n

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Probeer Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

De studie gaat over ZIKV in het volwassen menselijk brein, een gevaarlijk virus dat de wereld teistert. Het proces maakt gebruik van Mind the Graph illustraties.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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