{"id":8728,"date":"2019-04-23T16:35:01","date_gmt":"2019-04-23T19:35:01","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8728"},"modified":"2022-10-18T08:23:59","modified_gmt":"2022-10-18T11:23:59","slug":"visual-abstract-example","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nb\/visuelt-abstrakt-eksempel\/","title":{"rendered":"Visuelt sammendrag laget av en bruker for \u00e5 forklare forskningsartikkelen \"Optimized Small-Molecule Pull-Downs Define MLBP1 as an Acyl-Lipid-Binding Protein\" av Yelena Sterlin."},"content":{"rendered":"

A visual abstract is not easy to create, but’s here to stay. So we always love to show off our users’ amazing work as an inspiring example of visual abstract. We want to empower scientists to enable a more more visual and reachable science.<\/p>\n

I innlegget vil jeg vise deg litt av den opprinnelige forskningen av Jelena Sterlin<\/a> og kolleger. Hun er doktorgradsstudent ved fakultetet for landbruk, mat og milj\u00f8 ved Hebrew University of Jerusalem.<\/p>\n

Hennes nye artikkel Optimaliserte sm\u00e5molekyl\u00e6re pull-downs definerer MLBP1 som et acyllipidbindende protein<\/a> <\/strong>brings light to the protein-metabolite interactions in plants, with focus on the abscisic acid (ABA) receptors. She is also a mind the graph subscriber, so she created a infographic in ta hensyn til grafen<\/a> to explain their methodology.<\/p>\n

Betydningen av START-domenerelaterte proteiner<\/strong><\/h2>\n

 <\/p>\n

If\u00f8lge Naturmagasinet<\/a>Abscisinsyre (ABA) er det viktigste plantehormonet som er involvert i abiotisk stressrespons og tilpasning. Det er ogs\u00e5 en kandidat til \u00e5 bli et agrikjemikalie. ABA ble f\u00f8rst oppdaget p\u00e5 1960-tallet. Siden den gang har det vist seg \u00e5 v\u00e6re en viktig regulator for s\u00e5 forskjellige prosesser som hvilemodus, spiring, fr\u00f8utvikling og respons p\u00e5 biotisk og abiotisk stress.<\/p>\n

De tidligste hendelsene i ABA-signalveien involverer ABA-binding til PYR\/PYL\/RCAR-reseptorer. Reseptorene tilh\u00f8rer START-domene-superfamilien.<\/p>\n

The START protein domains are a lipid-binding domain present in genomes of bacteria, protists, yeast, plants and animals. However, they are more common in plants. According to Schrick<\/a>Tilstedev\u00e6relsen av START-domener i evolusjon\u00e6rt fjerne arter som dyr og planter tyder p\u00e5 at det finnes en konservert mekanisme for interaksjon mellom proteiner og lipider\/steroler.<\/p>\n

Artikkelen ble publisert i Plantejournalen<\/a> fokuserer p\u00e5 PYR\/PYL\/RCARs ABA-reseptorer. Forskerne bestemte seg for \u00e5 optimalisere en metode som gj\u00f8r det mulig \u00e5 identifisere START-domene og START-domene-relaterte proteinligander i planter. \"START-domeneproteinligandene er uunnv\u00e6rlige for at proteinet skal fungere som det skal, b\u00e5de hos dyr og planter, og det ble p\u00e5vist at START-domeneproteiner fra planter er involvert i viktige fysiologiske prosesser.\"<\/em><\/p>\n

Et visuelt sammendrag av metoden<\/strong><\/h2>\n

 <\/p>\n

For \u00e5 forklare metoden har forskerne laget en infografikk med grafiske illustrasjoner. Den er i\u00f8ynefallende og lettere \u00e5 forst\u00e5. <\/strong><\/h4>\n

 <\/p>\n

Infografikken nedenfor viser den eksperimentelle arbeidsflyten. Som du kan se, har de uttrykt og renset fire START-proteiner. De filtrerte og inkuberte supernatanten som inneholdt den native, l\u00f8selige fraksjonen, med streptavidin-sefarose, en affinitetsresin som gir p\u00e5litelig og h\u00f8y oppl\u00f8selighet.-oppl\u00f8selig rensing av biomolekyler. Deretter analyserte de alikvoter ved hjelp av western blot. For \u00e5 identifisere liganden eluerte de antatte ligander og analyserte dem med LC-MS-system (v\u00e6skekromatografi og massespektrometri). De molekyl\u00e6re strukturene til de antatte ligandene av interesse ble bestemt ved hjelp av tandem-massespektrometri.<\/p>\n

 <\/p>\n

\"visuelt<\/p>\n

The authors presented a good technique for initial probing of protein ligands in plants. They adjusted the approach to discover START ligands. However, you can adopt the method to ligands of different chemical nature by adjustment of analytical conditions.<\/p>\n

If you want to show your research using scientific illustrations and visual abstracts, you can use Mind the Graph as well. So, are you ready to improve your communication in science?<\/p>\n

\"forh\u00e5ndsvisning_250\"<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Visuelle abstrakte bilder er ikke enkle \u00e5 skape, men de er kommet for \u00e5 bli. Derfor elsker vi alltid \u00e5 vise frem brukernes fantastiske arbeid som et inspirerende eksempel p\u00e5 visuelle abstrakter. Vi \u00f8nsker \u00e5 gj\u00f8re det mulig for forskere \u00e5 skape en mer visuell og tilgjengelig vitenskap. I dette innlegget vil jeg vise deg litt av [...]<\/p>","protected":false},"author":11,"featured_media":8741,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[193,40],"tags":[291,96,292,245,294,295,554,775,293,382],"yoast_head":"\nVisual abstract created by Mind the Graph user. Attractive scientific figure!<\/title>\n<meta name=\"description\" content=\"See the visual abstract created by the MindtheGraph subscriber Yelena Sterling to explain her research in an attractive and instructive way. 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