{"id":8713,"date":"2019-04-18T18:07:31","date_gmt":"2019-04-18T21:07:31","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8713"},"modified":"2022-10-18T08:24:00","modified_gmt":"2022-10-18T11:24:00","slug":"brain-damage-pig-brains-alive-hours-death","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nb\/brain-damage-pig-brains-alive-hours-death\/","title":{"rendered":"Hjerneskade: en infografikk for \u00e5 forst\u00e5 den nye Nature-rapporten"},"content":{"rendered":"

Forskere fra Yale University holdt grisehjerner i live utenfor kroppen i flere timer etter d\u00f8den. Artikkelen Gjenoppretting av hjernens sirkulasjon og cellefunksjoner flere timer etter obduksjon<\/strong> explains the experiment using pigs brains, that can brings light to brain damage research. The\u00a0Nature magazine\u00a0publisert <\/a>avisen den 17. april.<\/p>\n

\"I mesteparten av menneskehetens historie var d\u00f8den veldig enkel.\"<\/em> says Christof Koch. He is the president and chief scientist of the Allen Institute for Brain Science in Seattle, Washington. “N\u00e5 m\u00e5 vi stille sp\u00f8rsm\u00e5l ved hva som er irreversibelt.\"\u00a0<\/em><\/p>\n

There isn’t any communication between the neurons in these brains, so there was no consciousness. But the cells were alive \u2014 and that alone is a very big discovery.<\/p>\n

\"Tidligere funn har vist at cellene gjennomg\u00e5r en celled\u00f8dsprosess i l\u00f8pet av noen minutter.\"<\/em>\u00a0said Nenad Sestan, the Yale neuroscientist who led the research during a press conference. \"Det vi viser, er at celled\u00f8dsprosessen er en gradvis, trinnvis prosess, og at noen av disse prosessene kan utsettes, bevares eller til og med reverseres.\"<\/em><\/p>\n

Hjerneskadeeksperimentet<\/strong><\/h3>\n

According to Nature Magazine,\u00a0the researchers tested how well the brains fared during a six-hour period. They found that neurons and other brain cells had restarted normal metabolic functions, such as consuming sugar and producing carbon dioxide. Also, the brains\u2019 immune systems seemed to be working. The structures of individual cells and sections of the brain were preserved. In contrast, cells in control brains, which did not receive the nutrient- and oxygen-rich solution, collapsed. And when the scientists applied electricity to tissue samples from the treated brains, they found that individual neurons could still carry a signal.<\/p>\n

Forskerne utviklet et system kalt BrainEx, som er spesialdesignet for \u00e5 dempe noen av prosessene som er ansvarlige for nedbrytning av vev i post mortem-hjerner. Systemet g\u00e5r ut p\u00e5 \u00e5 pumpe en l\u00f8sning som kalles BEx perfusat. L\u00f8sningen er en egenutviklet blanding av beskyttende, stabiliserende og kontrastmidler som fungerer som en erstatning for blod. Perfusatet inneholder ogs\u00e5 kjemikalier som stopper oksidasjonen av kroppsvev og dermed apoptose. Det inneholder ogs\u00e5 en nevral aktivitetsblokker, som har to form\u00e5l. De pumpet l\u00f8sningen inn i den isolerte hjernens hovedarterier ved normal kroppstemperatur.<\/p>\n

 <\/p>\n

\"Griser\"<\/a>
Figuren i artikkelen viser hvordan en hel hjerne ble koblet til BEx-enheten. Tilkoblingen av svinehjernen til perfusjonssystemet ble gjort via arterielle ledninger.\u00a0<\/strong><\/figcaption><\/figure>\n

 <\/p>\n

Forskerne brukte rundt 300 grisehoder fra et slakteri under det amerikanske landbruksdepartementet. Etter \u00e5 ha optimalisert teknologien koblet teamet 32 grisehjerner til BrainEx-systemet. Tilkoblingen skjedde fire timer etter at grisene var avlivet, og etter at hjernene var fjernet fra hodeskallene. Dette datastyrte nettverket av pumper, varmeovner og filtre kontrollerte str\u00f8mning, temperatur og en egenutviklet perfusatl\u00f8sning i seks timer.<\/p>\n

En infografikk for \u00e5 forst\u00e5 eksperimentet<\/strong><\/h2>\n

 <\/p>\n

\"preview_77833<\/a><\/p>\n

 <\/p>\n

I created the infographic using Mind the Graph. If you want to use attractive scientific illustrations to reach more people with your research, you can use mind the Graph too!<\/p>\n

\"forh\u00e5ndsvisning_250\"<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Forskere fra Yale University holdt grisehjerner i live utenfor kroppen i flere timer etter d\u00f8den. Artikkelen Restoration of brain circulation and cellular functions hours post-mortem forklarer eksperimentet med grisehjerner, som kan kaste lys over forskningen p\u00e5 hjerneskader. Tidsskriftet Nature publiserte artikkelen 17. april. \"I mesteparten av menneskehetens historie har d\u00f8den v\u00e6rt veldig enkel,\" [...].<\/p>","protected":false},"author":11,"featured_media":8721,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[54,288,287,286,282,554,71,964,775,70],"yoast_head":"\nBrain damage: an infographic to understand the new Nature paper - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/nb\/brain-damage-pig-brains-alive-hours-death\/\" \/>\n<meta property=\"og:locale\" content=\"nb_NO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brain damage: an infographic to understand the new Nature paper - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/nb\/brain-damage-pig-brains-alive-hours-death\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2019-04-18T21:07:31+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-18T11:24:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/04\/cover-pigs.png\" \/>\n\t<meta property=\"og:image:width\" content=\"607\" \/>\n\t<meta property=\"og:image:height\" content=\"352\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabiola Soares\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabiola Soares\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Brain damage: an infographic to understand the new Nature paper - Mind the Graph Blog","description":"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/nb\/brain-damage-pig-brains-alive-hours-death\/","og_locale":"nb_NO","og_type":"article","og_title":"Brain damage: an infographic to understand the new Nature paper - Mind the Graph Blog","og_description":"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.","og_url":"https:\/\/mindthegraph.com\/blog\/nb\/brain-damage-pig-brains-alive-hours-death\/","og_site_name":"Mind the Graph Blog","article_published_time":"2019-04-18T21:07:31+00:00","article_modified_time":"2022-10-18T11:24:00+00:00","og_image":[{"width":607,"height":352,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/04\/cover-pigs.png","type":"image\/png"}],"author":"Fabiola Soares","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabiola Soares","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/brain-damage-pig-brains-alive-hours-death\/","url":"https:\/\/mindthegraph.com\/blog\/brain-damage-pig-brains-alive-hours-death\/","name":"Brain damage: an infographic to understand the new Nature paper - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2019-04-18T21:07:31+00:00","dateModified":"2022-10-18T11:24:00+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132"},"description":"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/brain-damage-pig-brains-alive-hours-death\/#breadcrumb"},"inLanguage":"nb-NO","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/brain-damage-pig-brains-alive-hours-death\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/brain-damage-pig-brains-alive-hours-death\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Brain damage: an infographic to understand the new Nature paper"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"nb-NO"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132","name":"Fabiola Soares","image":{"@type":"ImageObject","inLanguage":"nb-NO","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","caption":"Fabiola Soares"},"url":"https:\/\/mindthegraph.com\/blog\/nb\/author\/fabiola\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/posts\/8713"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/comments?post=8713"}],"version-history":[{"count":10,"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/posts\/8713\/revisions"}],"predecessor-version":[{"id":23429,"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/posts\/8713\/revisions\/23429"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/media\/8721"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/media?parent=8713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/categories?post=8713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/nb\/wp-json\/wp\/v2\/tags?post=8713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}