{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/","title":{"rendered":"Alzheimers sykdom: En vitenskapelig infografikk"},"content":{"rendered":"

It’s always a celebration when we see the amazing work of our users.\u00a0Jeg har allerede skrevet<\/a> about the research of Dr. Alessandra Martini, Dr.\u00a0Stefania Forner<\/a>\u00a0and their colleagues.\u00a0They are Postdoctoral Researchers at University of California and mind the graph users. \u00a0A few months ago, I showed infografikken<\/a>\u00a0Dr. Stefania Forner har skrevet en oversiktsartikkel publisert i Trends in Neurosciences med tittelen Synaptic impairment in Alzheimer's Disease: En dysregulert symfoni.<\/p>\n

I dag vil jeg snakke om deres nye oversiktsartikkel med tittelen Fra fortid til fremtid: hva dyremodeller har l\u00e6rt oss om Alzheimers sykdom.<\/a><\/p>\n

Alzheimers sykdom (AD) er en nevrodegenerativ lidelse som f\u00f8rer til kognitiv svikt og hukommelsestap. Det er viktig \u00e5 forst\u00e5 sykdomsmekanismene for \u00e5 kunne forbedre livskvaliteten til pasientene og finne en effektiv behandling. Til tross for enorme anstrengelser innen akademia og legemiddelindustrien finnes det i dag ingen effektive behandlinger. Alzheimers sykdom er den sjette st\u00f8rste d\u00f8ds\u00e5rsaken i USA og rammer 35 millioner mennesker over hele verden.<\/p>\n

Infografikk om Alzheimers sykdom<\/h2>\n

 <\/p>\n

The majority of AD patients are elder subjects that commonly sufferfrom a variety of co-morbidities. Diabetes, osteoporosis, renal disease, obesity, hypertension and hypercholes-terolemia\/dyslipidemia, stroke, and seizure are the main comorbidities affecting the onset and progression of AD, adding intricacy tothe pathogenesis of the disease.<\/p>\n

\"infografikk
Infographic showing comorbidities in Alzheimer\u2019s disease (AD). Past to Future: What Animal Models Have Taught Us About Alzheimer\u2019s Disease<\/figcaption><\/figure>\n

 <\/p>\n

\n

Til tross for intensiv forskningsinnsats de siste ti\u00e5rene er mekanismene som ligger til grunn for sporadisk AD (sAD), som er den vanligste formen for sykdommen, fortsatt ukjente. Dette skyldes, i hvert fall delvis, at de fleste sAD-pasienter er eldre mennesker som ofte lider av en rekke komorbiditeter (f.eks. hjerneslag, stress, diabetes, kramper, osteoporose og nyresykdom).<\/em><\/p>\n<\/blockquote>\n

Den neste infografikken viser dannelsen og mekanismene for synaptisk toksisitet av tau- og beta-amyloidoligomerer.<\/p>\n

 <\/p>\n

\"infografico
Fra fortid til fremtid: Hva dyremodeller har l\u00e6rt oss om Alzheimers sykdom<\/figcaption><\/figure>\n

 <\/p>\n

\n

Ved tauopatier er det en reduksjon i antall dendrittiske pigger. Tau kommer ikke inn i nevronkjernen, noe som resulterer i DNA-skader. Antallet mitokondrier og antallet presynaptiske vesikler reduseres, noe som f\u00f8rer til synaptisk tap. Dette tapet skyldes ogs\u00e5 at tau kommer inn i dendritter og postsynaptiske omr\u00e5der. Tau aggregerer ogs\u00e5 ekstracellul\u00e6rt, slik at det kan fanges opp av andre nevroner.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

Hun har ogs\u00e5 laget en infografikk for \u00e5 vise inflammatoriske mekanismer knyttet til Alzheimers sykdom (AD)<\/p>\n

 <\/p>\n

\"infografico<\/p>\n

 <\/p>\n

\n

De siste \u00e5rene har vi v\u00e6rt spesielt interessert i \u00e5 forst\u00e5 hvordan betennelse p\u00e5virker beta-amyloid- og tau-patologi. Eldre mennesker er utsatt for virus- og bakterieinfeksjoner, og disse mikrobielle agensene kan forverre den eksisterende betennelsestilstanden i hjernen og fremskynde den kognitive tilbakegangen.<\/em><\/p>\n<\/blockquote>\n

Gratulerer, Dr. Stefania Forner, for ditt flotte arbeid!<\/p>\n

If you are a scientist and want to create beautiful figures for your paper, you can become a mind the graph user right now.<\/p>\n

\"untitled-creation63724<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Det er alltid en feiring n\u00e5r vi ser det fantastiske arbeidet til brukerne v\u00e5re. Jeg har allerede skrevet om forskningen til Dr. Alessandra Martini, Dr. Stefania Forner og deres kolleger. De er postdoktorer ved University of California og er grafbrukere. For noen m\u00e5neder siden viste jeg infografikken Dr. Stefania Forner laget for oversiktsartikkelen som ble publisert i Trends [...]<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"nb_NO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-23T18:56:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-18T11:30:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png\" \/>\n\t<meta property=\"og:image:width\" content=\"755\" \/>\n\t<meta property=\"og:image:height\" content=\"487\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabiola Soares\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabiola Soares\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Alzheimer\u2019s disease: A scientific infographic - 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