{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nb\/autofagi-vinner-nobelpris-i-medisin\/","title":{"rendered":"Autofagi vinner Nobelprisen i medisin"},"content":{"rendered":"

Autofagi er involvert i flere tilstander, blant annet kreft og nevrologiske sykdommer. Den fungerer som kroppens interne resirkuleringsprogram. En forstyrret autofagi har imidlertid blitt knyttet til Parkinsons sykdom, diabetes, kreft og andre aldersrelaterte lidelser.<\/p>\n

After this little introduction on the importance of the autophagy process, it is no surprise that new discoveries in this field could lead to a Nobel Prize. Indeed, last Monday, the researcher Yoshino Ohsumi won the Nobelprisen i medisin<\/a> for \u00e5 identifisere de f\u00f8rste viktige genene for autofagi.<\/p>\n

\u201cI don\u2019t feel comfortable competing with many people, and instead I find it more enjoyable doing something nobody else is doing. In a way, that\u2019s what science is all about, and the joy of finding something inspires me.\u201d Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Hvordan gjorde Ohsumi det?<\/h3>\n

In his lab, Ohsumi had engineered yeast strains that accumulated autophagosomes during starvation. This accumutation could only have happened if essential genes for autophagy were inactive. Thus, Ohsumi started manipulating the cells to several gene mutations and managed to induce autophagy.<\/p>\n

\"Autofagi<\/a><\/p>\n

Autofagi har eksistert i mange \u00e5r<\/h3>\n

Selv om autofagi har v\u00e6rt kjent de siste 50 \u00e5rene, var det f\u00f8rst p\u00e5 1990-tallet, med Ohsumi-studiene, at denne prosessens betydning ble anerkjent.
\nOhsumi har allerede f\u00e5tt noen fans for arbeidet sitt:<\/p>\n

\"Autofagi<\/a><\/p>\n

\n

\"Jeg er veldig glad for at han har f\u00e5tt \u00e5rets Nobelpris, det er veldig velfortjent. Laboratoriet hans arbeider hovedsakelig med gj\u00e6r. De gjorde de f\u00f8rste screeningene som gjorde det mulig \u00e5 oppdage n\u00f8kkelgener som er involvert i autofagi. S\u00e5 mange andre laboratorier har utnyttet hans oppdagelser, direkte eller indirekte, for \u00e5 se hvorfor det er viktig i forbindelse med sykdommer.\"<\/p>\n

David Rubinsztein<\/a> – deputy director of the Cambridge Institute for Medical Research<\/p>\n<\/blockquote>\n

\"Autofagi<\/a><\/p>\n

\n

\"Jeg synes det er veldig viktig at dette forskningsomr\u00e5det blir anerkjent. Det viktige prinsippet her er \u00e5 g\u00e5 etter felles mekanismer i sykdom. Det \u00e5pner for andre m\u00e5ter \u00e5 behandle disse lidelsene p\u00e5 enn de mer konvensjonelle sykdomsspesifikke tiln\u00e6rmingene.\"<\/p>\n

Giovanna Mallucci<\/a> - professor i klinisk nevrovitenskap ved University of Cambridge<\/p>\n<\/blockquote>\n

\"Autofagi<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Autofagi er involvert i flere tilstander, blant annet kreft og nevrologiske sykdommer. Den fungerer som kroppens interne resirkuleringsprogram. Men en forstyrret autofagi har blitt satt i sammenheng med Parkinsons sykdom, diabetes, kreft og andre aldersrelaterte lidelser. Etter denne lille introduksjonen om autofagiprosessens betydning, er det ingen overraskelse at nye oppdagelser [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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