{"id":5346,"date":"2016-03-03T13:41:11","date_gmt":"2016-03-03T16:41:11","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=5346"},"modified":"2022-10-18T08:29:24","modified_gmt":"2022-10-18T11:29:24","slug":"zika-virus-graphical-abstract","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nb\/zika-virus-grafisk-abstrakt\/","title":{"rendered":"Grafisk sammendrag om mikrokefali for\u00e5rsaket av zikaviruset"},"content":{"rendered":"

Forst\u00e5 det grafiske sammendraget av zikaviruset: Hvordan det reduserer hjernest\u00f8rrelsen<\/h3>\n

I dag har en forskningsstudie lagt frem interessante bevis for zikavirusets rolle i misdannelsen av nervevev. Ah, ja, f\u00f8r du sp\u00f8r, menneskelig nervevev.<\/p>\n

Dette ble gjort p\u00e5 en elegant m\u00e5te av gruppen til Dr. Stevens Rehen, en internasjonalt kjent forsker innen stamcelleforskning og, i nyere tid, celleprogrammering.<\/p>\n

Figuren nedenfor oppsummerer funnene fra papiret<\/a>men jeg skal pr\u00f8ve \u00e5 forklare det kort.<\/p>\n

 <\/p>\n

\"blogg<\/p>\n

This insightful Zika virus graphical abstract was done with Mind the graph. Isn’t is cool?<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

As you can see in the picture above, three distinct approaches were taken in this research. All of them confirming that Zika virus has a direct impact on\u00a0how brain cells evolve to form a proper neuronal tissue, aka, “incudes brain malformation”.\"zikavirus<\/a>Mikrokefali er bare \u00e9n misdannelse i hjernen. Det artikkelen antyder, er noe enda mer grunnleggende.<\/p>\n

De viser hvordan zikaviruset:<\/p>\n

    \n
  1. Fremmer celled\u00f8d<\/li>\n
  2. Induserer morfologiske endringer (i nevrosf\u00e6rer)<\/li>\n
  3. Reduserer veksten\/st\u00f8rrelsen p\u00e5 cerebrale organoider (minihjerner)<\/li>\n<\/ol>\n

    Zikaviruset kan p\u00e5 alle disse m\u00e5tene p\u00e5virke nevrogenesen under hjernens utvikling og for\u00e5rsake fenotypen du ser nedenfor.<\/p>\n

    \"zikavirus<\/a><\/p>\n

    <\/h3>\n

    Hvorfor ble det ikke gjort f\u00f8r?<\/h3>\n

    Den banebrytende tiln\u00e6rmingen var bruken av induserte pluripotente stamceller (iPS-celler) for \u00e5 kunne studere virusinfeksjon i humane celler.<\/p>\n

    With this process, a somatic cell harvested from a person is reprogrammed towards it’s initial state of pluripotent cell and can afterwards be differentiated into different cells, tissues, and more recently organs. This is the very beginning of “human tissue engineering “.<\/p>\n

    I studien har forfatterne ikke bare brukt iPS-celler, men ogs\u00e5 generert hjerneorganoider<\/a>, ogs\u00e5 kjent som \"minihjerner\", for \u00e5 forst\u00e5 hvordan tilstedev\u00e6relsen av zikaviruset p\u00e5virker dannelsen av dette nervevevet.<\/p>\n

    Slike cellekulturer regnes som tredimensjonale (3D) strukturer og gir flere hint om organarkitekturen. Dette er organoidens \u00e5r i henhold til \u00d8konomen<\/a>. Ved hjelp av denne innovative tiln\u00e6rmingen kunne forskerne forst\u00e5 hvordan zikaviruset retter seg mot menneskelige hjerneceller og reduserer deres levedyktighet og vekst som nevrosf\u00e6rer og hjerneorganoider.<\/p>\n

    Den papir<\/a> er p\u00e5 forh\u00e5ndstrykk i det innovative tidsskriftet PeerJ. Du kan til og med kommentere og hjelpe forfatterne med \u00e5 forbedre den underveis i prosessen. Du kan se sammendraget nedenfor og f\u00e5 full tilgang ved \u00e5 klikke p\u00e5 her<\/a>.<\/p>\n

    \"zikavirus<\/a><\/p>\n

    Merk: To m\u00e5neder etter forh\u00e5ndsutgaven p\u00e5 PeerJ datert mars 2016, ble den endelige artikkelen utgitt, og til v\u00e5r overraskelse var den publisert p\u00e5 Science <\/a>Magazine, et av verdens mest prestisjetunge vitenskapelige tidsskrifter.<\/p>\n

    -> Les hele artikkelen av Garcez et al. i Science <-<\/a><\/p>\n

    \"zikavirus<\/a><\/p>\n

    Let more people know about it sharing this post. This is a matter of global public health, as \u00a0already stated by the Verdens helseorganisasjon<\/a>\u00a0(WHO).<\/p>\n

    \n

     <\/p>\n

    Vite hva WHO gir r\u00e5d om zikaviruset<\/a>\u00a0overf\u00f8ring og smitte:<\/p>\n

    \n

    Overf\u00f8ring<\/h3>\n

    Zikaviruset smitter f\u00f8rst og fremst til mennesker gjennom bitt fra Aedes<\/i> mygg, som ofte lever i n\u00e6rheten av bygninger i urbane omr\u00e5der og vanligvis er aktive i dagslys (den h\u00f8yeste stikkeaktiviteten inntreffer tidlig om morgenen og sent p\u00e5 ettermiddagen).<\/p>\n

    Noe tyder p\u00e5 at zikaviruset ogs\u00e5 kan overf\u00f8res til mennesker gjennom blodoverf\u00f8ring, perinatal smitte og seksuell smitte. Disse smittem\u00e5tene er imidlertid sv\u00e6rt sjeldne.<\/p>\n

    Inkubasjonstiden er vanligvis mellom 2 og 7 dager.<\/p>\n

    Tegn og symptomer<\/h3>\n

    Zikavirusinfeksjon kjennetegnes av lavgradig feber (mindre enn 38,5 \u00b0C), ofte ledsaget av et makulopapul\u00f8st utslett. Andre vanlige symptomer er muskelsmerter, leddsmerter med mulig hevelse (s\u00e6rlig i de sm\u00e5 leddene i hender og f\u00f8tter), hodepine, smerter bak \u00f8ynene og konjunktivitt. Ettersom symptomene ofte er milde, kan infeksjonen bli oversett eller feildiagnostisert som denguefeber.<\/p>\n

    Det forventes en h\u00f8y forekomst av asymptomatisk infeksjon med zikavirus, i likhet med andre flavivirus, som denguevirus og West Nile-virus. De fleste blir helt friske uten alvorlige komplikasjoner, og sykehusinnleggelsesraten er lav. Hittil er det ikke rapportert om d\u00f8dsfall i forbindelse med zikaviruset.<\/p><\/blockquote>\n

     <\/p>\n

    Oppdatert 3. mai 2016.<\/p>","protected":false},"excerpt":{"rendered":"

    Forst\u00e5 Zika-virusets grafiske sammendrag: Hvordan det reduserer hjernest\u00f8rrelsen I dag har en forskningsstudie lagt frem interessante bevis for Zika-virusets rolle i misdannelsen av nervevev. Ah, ja, f\u00f8r du sp\u00f8r, menneskelig nervevev. Dette ble gjort p\u00e5 en elegant m\u00e5te av gruppen til Dr. Stevens Rehen, en internasjonalt kjent forsker innen [...].<\/p>","protected":false},"author":4,"featured_media":7136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[956],"tags":[96,201,200,203,202,205,554,71,250,204,199],"yoast_head":"\nZika virus graphical abstract on microcephaly - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This insightful Zika virus graphical abstract was done with Mind the graph. 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