{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nb\/suksess-case-hoyopploselig-synkrotronbasert-rontgenmikrotomografi-som-verktoy-for-a-avdekke-hjernens-tredimensjonale-nevronale-arkitektur\/","title":{"rendered":"H\u00f8yoppl\u00f8selig synkrotronbasert r\u00f8ntgenmikrotomografi som et verkt\u00f8y for \u00e5 avdekke hjernens tredimensjonale nevronale arkitektur Paper Review"},"content":{"rendered":"

R\u00f8ntgenmikrotomografi har vokst frem som en ny metode for \u00e5 dechiffrere hjernens cytoarkitektur og konnektivitet, og her presenterer vi en metode for avbildning av hele nevroner.<\/p>\n\n\n\n

H\u00f8yoppl\u00f8selig synkrotronbasert r\u00f8ntgenmikrotomografi som et verkt\u00f8y for \u00e5 avdekke hjernens tredimensjonale nevronale arkitektur<\/strong><\/h2>\n\n\n\n

I artikkelen \"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain\" (H\u00f8yoppl\u00f8selig synkrotronbasert r\u00f8ntgenmikrotomografi som et verkt\u00f8y for \u00e5 avdekke hjernens tredimensjonale nevronarkitektur) skriver Matheus de Castro Fonseca et al. (2018) at studiet av nevroner som individualiserte enheter begynte p\u00e5 1800-tallet med etableringen av nevronl\u00e6ren. <\/p>\n\n\n\n

I l\u00f8pet av de siste \u00e5rene har det blitt gjort store anstrengelser for \u00e5 forst\u00e5 nevronal organisering og konnektivitet i intakte hjernepr\u00f8ver. Golgi-Cox-merkingsteknikken gir god kontrast for spesifikk merking av nevroner for r\u00f8ntgenmikrotomografi. <\/p>\n\n\n\n

Nevroner har en distinkt morfologi og spesifikke konnektivitetsm\u00f8nstre som er avgj\u00f8rende for at de skal fungere korrekt. Forskerne presenterer en avbildningsmetode som kombinerer synkrotronbasert r\u00f8ntgenmikrotomografi med Golgi-Cox-impregneringsprotokollen. <\/p>\n\n\n\n

Metoden gir en h\u00f8yere og mer homogen kontrast av relativt tynt fordelte hele nevroner i vevet.<\/p>\n\n\n\n

Hjernene ble inkubert i Golgi-Cox-fargel\u00f8sning i 14 dager, beskyttet mot lys. Etter inkubasjonsperioden ble hjernene snittet i serier ved hjelp av et vibratom.<\/strong><\/p>\n\n\n\n

Kontroller originalartikkel her<\/a>.<\/p>\n\n\n\n

Grafisk sammendrag drevet av Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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\"\"<\/a>
Laget med Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Forfatteren brukte Mind the Graph<\/a> to create a schematic illustration that represents an adult mice being i.p. injected with saline or pilocarpine solution (280\u2009mg\/kg). Representing complex processes with infographics is a good way to make them easily understandable, without leaving aside the details and crucial information.<\/p>\n\n\n\n

Some of the researchers\u2019 results seem to consolidate what was previously known about this area: \u201cThe mercury-based neuron impregnation showed here, allowed us to clearly define whole neurons mainly because of a more continuous and homogeneous impregnant of the cells and much reduced density of artifacts,\u201d de Castro Fonseca suggested.<\/p>\n\n\n\n

Avisenes innvirkning og resultater<\/strong><\/h2>\n\n\n\n

Vi kan analysere med Altmetric<\/a> data at denne avisens oppmerksomhetsscore p\u00e5 nett er h\u00f8yere enn 64%<\/strong><\/strong> av alle andre artikler av tilsvarende alder i Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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\"\"<\/a>
Kilde Altmetrikk<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Forbedre artikkelens tilgjengelighet ved hjelp av infografikk.<\/p>\n\n\n\n

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Pr\u00f8v Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Ta en titt p\u00e5 den nye metoden for \u00e5 dechiffrere hjernens cytoarkitektur og konnektivitet med Mind the Graphs illustrasjoner.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/nb\/suksess-case-hoyopploselig-synkrotronbasert-rontgenmikrotomografi-som-verktoy-for-a-avdekke-hjernens-tredimensjonale-nevronale-arkitektur\/\" \/>\n<meta property=\"og:locale\" content=\"nb_NO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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