{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nb\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"Zikaviruset replikeres i hjernevev hos voksne mennesker og svekker synapser og hukommelse hos mus Paper Review"},"content":{"rendered":"

ZIKV er et farlig virus som herjer i verden. Derfor studerer forfatteren i dette tilfellet replikasjonen i den voksne menneskehjernen.<\/p>\n\n\n\n

Zikavirus (ZIKV) infiserer hjernevev hos voksne og for\u00e5rsaker hukommelsessvikt hos mus<\/strong><\/h2>\n\n\n\n

A group from the School of Pharmacy led by Claudia Figueiredo (2019) studied how zika virus replicates in adult human brain tissue and impairs synapses and memory in mice. Zika virus is an arbovirus belonging to the Flaviviridae family responsible for a recent major outbreak in Latin America. <\/p>\n\n\n\n

ZIKV has been found in the brains and CSF of adult patients. NS2B immunoreactivity colocalized with NeuN-immunoreactive cells, but not with GFAP or F4\/80, indicating that neurons are targeted by ZikV in the mature human tissue. In adult immunocompetent mice infected by intracerebroventricular infusion of ZIKV, high levels of ZikV RNA are detected in the frontal cortex and hippocampus, and mature neurons are the main cell type infected. <\/p>\n\n\n\n

Det er p\u00e5vist forh\u00f8yede niv\u00e5er av TNF-\u03b1 i hjernen, intens mikrogliose, oppregulert uttrykk av komplementsystemets proteiner (C1q og C3) og skade p\u00e5 synapser i hippocampus.<\/p>\n\n\n\n

Studien omfattet 9 like store kvadranter.<\/strong><\/p>\n\n\n\n

Kontroller originalartikkel her<\/a>.<\/p>\n\n\n\n

Grafiske sammendrag drevet av Mind the Graph<\/strong><\/h2>\n\n\n\n
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Laget med Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Den f\u00f8rste figuren viser et tilfelle der vevsfragmenter fra den humane temporallappen ble sk\u00e5ret i 400 \u00b5m store skiver og holdt i kultur i 4 dager f\u00f8r de ble inkubert med ZIKV (107 PFU) eller mock-medium i 1 time, etterfulgt av utvasking. <\/p>\n\n\n\n

<\/div>\n\n\n
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Laget med Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Den andre viser at voksne mus fikk en infusjon av 105 PFU ZIKV, UV-inaktivert ZIKV eller mock-medium i lateral ventrikkel i hjernen.<\/p>\n\n\n\n

Konklusjonene ser ut til \u00e5 underbygge det som tidligere var kjent om dette emnet: \"ZIKV angriper hukommelsesrelaterte hjerneomr\u00e5der uavhengig av om infeksjonsveien er sentral eller perifer. Viruset har blitt p\u00e5vist i ryggmargsv\u00e6sken hos voksne pasienter med nevrologiske komplikasjoner\", hevder Figueiredo.<\/p>\n\n\n\n

De foresl\u00e5r at fremtidige studier som tar sikte p\u00e5 \u00e5 unders\u00f8ke de langsiktige nevrodegenerative konsekvensene av ZIKV-infeksjon er berettiget. Hvis man finner m\u00e5ter \u00e5 forebygge signalavvik som f\u00f8rer til hjernedysfunksjon, kan det bane vei for intervensjonsstrategier som kan forsinke eller forebygge utviklingen av alvorlige nevrologiske tilstander.<\/p>\n\n\n\n

Avisenes innvirkning og resultater<\/strong><\/h2>\n\n\n\n

Vi kan analysere med Altmetric<\/a> data at denne avisens oppmerksomhetsscore p\u00e5 nett er h\u00f8yere enn 95%<\/strong><\/strong> of all other articles of a similar age in Nature<\/strong> Tidsskrifter.<\/strong><\/p>\n\n\n\n

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Kilde Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Use the power of infographics to boost your article too! Start a creation at Mind the Graph.<\/p>\n\n\n\n

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Pr\u00f8v Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Studien handler om ZIKV i hjernen hos voksne mennesker, et farlig virus som herjer verden over. Prosessen bruker Mind the Graph-illustrasjoner.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/nb\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"nb_NO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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