{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/nb\/koronavirus-covid-19-er-hydroksyklorokin-det-nye-hapet-tydeligvis-ja\/","title":{"rendered":"Koronavirus (covid-19): Er hydroksyklorokin det nye h\u00e5pet? Tilsynelatende ja."},"content":{"rendered":"

To nylige artikler som oppsummerte en in vitro-forskning og en liten klinisk studie var nok til at Donald Trump fikk FDA til \u00e5 innf\u00f8re en ny klinisk indikasjon for hydroksyklorokin: forbedring av symptomene hos pasienter som er rammet av koronaviruset (Covid-19).<\/p>\n

Dette er sannsynligvis den raskeste godkjenningsprosessen for et legemiddel i moderne tid, og presidenten har tilsynelatende rett. Overraskende for en global leder som ikke har mye til overs for vitenskap.<\/p>\n

\"\"<\/p>\n

De f\u00f8rste bevisene p\u00e5 at hydroksyklorokin p\u00e5virker viruset, kom fra denne artikkelen ble publisert i g\u00e5r p\u00e5 Cell Discovery<\/a>It’s just in vitro, with all the limitations, but it clearly shows the potential of the drug to kill the virus. When they submitted the paper 80,000 cases were confirmed in China, including 2946 deaths as well as over 10,566 confirmed cases in 72 other countries. At that time, the biggest hope was deposited on a drug called remdesivir.<\/p>\n

\"in
In vitro effects of hydrochloroquine on coronavirus (Covid-19). The column on the right shows the effects of the effective drug, as opposed to chloroquine or the control group on the left. It shows that the drug improved the ability of cells to extrude the viruses… it’s like helping to kick out a unwanted neighbor from your house. It helps! \ud83d\ude42 <\/figcaption><\/figure>\n

Men den st\u00f8rste nyheten kom fra en mindre klinisk studie som ble publisert dagen f\u00f8r. Tittelen er Hydroksyklorokin og azitromycin som behandling av covid-19: resultater fra en \u00e5pen, ikke-randomisert klinisk studie og kan lastes ned i sin \"in press\"-versjon<\/a><\/p>\n

I en studie med bare 20 pasienter viste forfatterne at hydroksyklorokin var effektivt mot koronavirusinfeksjonen Covid-19. Faktisk reduserte hydroksyklorokin 75% hos infiserte personer i l\u00f8pet av en 6-dagers periode, noe som er fantastisk. Enda bedre enn det, kombinasjonen med azitromycin forbedret behandlingseffekten til 95%.<\/p>\n

\"Kombinasjonsbehandling
Kombinasjonsbehandling med hydroklorokin og azitromycin er effektivt mot koronavirusinfeksjoner (Covid-19) hos mennesker. Fallet er dramatisk og gir nytt h\u00e5p for pasienter som er rammet.<\/figcaption><\/figure>\n

Behandlingen bedret symptomene, samtidig som den reduserte virusmengden hos pasientene. Legemidlet er tidligere godkjent for malaria, noe som betyr at det anses som trygt. \"S\u00f8stermedisinen\" klorokin var mindre effektiv. Bra for oss, for det er mye giftigere.<\/p>\n

Studien var ikke-randomisert og i liten skala, men det ser ut til at selv om epidemien startet i Kina, kommer l\u00f8sningen fra en global samfunnsinnsats. In vitro-artikkelen er faktisk kinesisk, mens den kliniske er europeisk, n\u00e6rmere bestemt fra Frankrike. Interessant nok er den opprinnelige legemiddelregistreringen for hydroksyklorokin fra det franske legemiddelfirmaet Sanofi, og den nylige kliniske studien ble gjennomf\u00f8rt i Marseille. Ale le bleu!<\/p>\n

Medscape har en utmerket artikkel om dette, for de som er interessert i mer detaljert informasjon.<\/a><\/p>\n

Vennligst referer til dette arbeidet som Gautret et al. (2020) Hydroksyklorokin og azitromycin som en behandling av COVID-19: resultater av en \u00e5pen ikke-randomisert klinisk studie. International Journal of Antimicrobial Agents - In Press 17. mars 2020 - DOI: 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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