{"id":9012,"date":"2019-06-03T11:07:17","date_gmt":"2019-06-03T14:07:17","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=9012"},"modified":"2022-10-18T08:23:58","modified_gmt":"2022-10-18T11:23:58","slug":"award-zika-virus-infection","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/apbalvojums-zika-virusa-infekcija\/","title":{"rendered":"Zikas v\u012bruss: Apbalvotais p\u0113t\u012bjums, kas sniedz jaunu ieskatu par ilgtermi\u0146a sek\u0101m"},"content":{"rendered":"

Vienm\u0113r ir p\u0101rsteidzo\u0161i par\u0101d\u012bt m\u016bsu lietot\u0101ju zin\u0101tnisko darbu. T\u0101p\u0113c \u0161odien es iepaz\u012bstin\u0101\u0161u j\u016bs ar Braz\u012blijas zin\u0101tnieci Isis de Souza un vi\u0146as darbu ar zikas v\u012brusu. Isis un vi\u0146as kol\u0113\u0123i p\u0113ta Zikas v\u012brusa infekcijas ietekmi uz pel\u0113m agr\u012bn\u0101 dz\u012bves posm\u0101. Vi\u0146a ir ar\u012b mind the graph lietot\u0101ja, un uzvar\u0113t\u0101jas prezent\u0101cij\u0101 ir izmantoti vizu\u0101lie resursi no Mind the graph. M\u0113s nevar\u0113tu b\u016bt lepn\u0101ki.<\/p>\n

Kas ir zikas v\u012bruss?<\/strong><\/h3>\n

Zikas v\u012bruss pieder Flaviviridae dzimtas v\u012brusu grupai. \u0160aj\u0101 grup\u0101 ietilpst vair\u0101ki patog\u0113ni v\u012brusi. Vispaz\u012bstam\u0101kais no tiem ir dzelten\u0101 drud\u017ea v\u012bruss, kas ir \u0161\u012bs dzimtas v\u012brusa tips un ar\u012b \u0123imenes nosaukuma iemesls, jo v\u0101rds flavus lat\u012b\u0146u valod\u0101 noz\u012bm\u0113 \"dzeltens\". Papildus tam citi flaviv\u012brusi ir Rietumn\u012blas v\u012bruss, tropu drud\u017ea v\u012bruss un \u0113r\u010du encefal\u012bta v\u012bruss.<\/p>\n

Flaviviridae dzimtas v\u012brusiem ir kop\u012bgs izm\u0113rs (40-65 nm) un v\u012brusu apvalki, kas p\u0101rkl\u0101j to aizsarg\u0101jo\u0161o ikozaedrisko nukleokaps\u012bdu. Ar\u012b \u0123en\u0113tiskais materi\u0101ls ir RNS, un tie par\u0101d\u0101s elektronu mikroskop\u0101.<\/p>\n

Zem\u0101k redzamaj\u0101 infografik\u0101 par\u0101d\u012bta zikas v\u012brusa pamatstrukt\u016bra:<\/p>\n

\"priek\u0161skat\u012bjums_90481\"<\/a><\/p>\n

 Zikas v\u012brusu galvenok\u0101rt izplata sievietes Stegomya aegypti<\/em> mosk\u012btu, kam vajag asinis, lai d\u0113tu olas. Kom\u0101rs ir akt\u012bvs galvenok\u0101rt dienas laik\u0101.<\/p>\n

Uzvar\u0113t\u0101js pap\u012brs<\/strong><\/h2>\n

P\u0113d\u0113j\u0101 laik\u0101 daudzi p\u0113tnieki p\u0113ta neirolo\u0123iskos trauc\u0113jumus, kas saist\u012bti ar iedzimtu saslim\u0161anu ar zikas v\u012brusu (ZIKV).<\/p>\n

Turkl\u0101t iedzimta mikrocef\u0101lija ir viena no visizteikt\u0101kaj\u0101m sek\u0101m, par ko zi\u0146ots ZIKV infic\u0113tiem jaundzimu\u0161ajiem. T\u0101p\u0113c p\u0113tniec\u012bb\u0101 tiek piev\u0113rsta uzman\u012bba ZIKV izrais\u012btas iedzimtas mikrocef\u0101lijas meh\u0101nismu izpratnei.<\/p>\n

Tom\u0113r tikai 1 l\u012bdz 13% pak\u013cautajiem aug\u013ciem p\u0113c piedzim\u0161anas konstat\u0113 fiziskas anom\u0101lijas. Turkl\u0101t tr\u016bkst inform\u0101cijas par perinat\u0101l\u0101s infekcijas ilgtermi\u0146a sek\u0101m.<\/p>\n

T\u0101p\u0113c Isis de Souza un vi\u0146as kol\u0113\u0123i izmantoja peles, lai p\u0113t\u012btu uzved\u012bbas un neiropatolo\u0123iskos apst\u0101k\u013cus un \u012bstermi\u0146a un ilgtermi\u0146a sekas, un public\u0113ja rezult\u0101tus rakst\u0101 ar nosaukumu. Zikas v\u012brusa infekcijas ak\u016btas un hroniskas neirolo\u0123iskas sekas pe\u013cu agr\u012bn\u0101 dz\u012bves posm\u0101.<\/strong><\/p>\n

Cilv\u0113kiem ar zikas v\u012brusa iedarb\u012bbu ir saist\u012bti daudzi kl\u012bniski st\u0101vok\u013ci, kas par\u0101d\u0101s vair\u0101kus m\u0113ne\u0161us vai gadus p\u0113c dzim\u0161anas. T\u0101p\u0113c pat tad, ja b\u0113rni nav piedzimu\u0161i ar mikrocef\u0101liju, vi\u0146iem var b\u016bt motoriski trauc\u0113jumi, ar krampjiem saist\u012bta garozas displ\u0101zija un citi neirolo\u0123iski trauc\u0113jumi.<\/p>\n

Autori nor\u0101da, ka \"sist\u0113miski infic\u0113ja jaundzimu\u0161\u0101s savva\u013cas tipa peles ar ZIKV un veica ilgtermi\u0146a nov\u0113ro\u0161anu attiec\u012bb\u0101 uz uzved\u012bbas, neiropatolo\u0123iskaj\u0101m un molekul\u0101raj\u0101m infekcijas sek\u0101m. M\u0113s zi\u0146ojam par \u012bstermi\u0146a un ilgtermi\u0146a komplik\u0101cij\u0101m p\u0113c ZIKV infekcijas pel\u0113m un par\u0101d\u0101m, ka agr\u012bna audz\u0113ja nekrozes faktora-\u03b1 (TNF-\u03b1) neitraliz\u0101cija da\u013c\u0113ji nov\u0113r\u0161 \u0161\u012bs kait\u012bg\u0101s sekas. M\u016bsu atkl\u0101jumi atkl\u0101j nepiecie\u0161am\u012bbu piev\u0113rst \u012bpa\u0161u uzman\u012bbu potenci\u0101lajam neiropatolo\u0123isko komplik\u0101ciju slogam b\u0113rniem un pusaud\u017eiem p\u0113c iedzimtas ZIKV iedarb\u012bbas un liecina, ka agr\u012bna neiroiekaisuma nom\u0101k\u0161ana var b\u016bt potenci\u0101ls \u0101rst\u0113\u0161anas veids, lai nov\u0113rstu ilgtermi\u0146a neirolo\u0123isk\u0101s sekas ZIKV infic\u0113tiem b\u0113rniem.\"<\/em><\/p>\n

 GE Healthcare Life Sciences atbalst\u012bt\u0101 balva<\/strong><\/h2>\n

\"Pr\u00eamio Jovem Talento em Ci\u00eancias da Vida\" jeb Jaun\u0101 talanta balvu dz\u012bv\u012bbas zin\u0101tn\u0113s (Young Talent Award in Life Sciences) veicina Braz\u012blijas Bio\u0137\u012bmijas un molekul\u0101r\u0101s biolo\u0123ijas biedr\u012bba un GE Healthcare Life Sciences. Zin\u0101tnisk\u0101 komiteja izv\u0113l\u0113j\u0101s piecus kandid\u0101tus, kuri prezent\u0113s savus darbus ikgad\u0113j\u0101 kongres\u0101, kas ir pas\u0101kums, kur\u0101 piedal\u0101s profesori un studenti no visas Lat\u012b\u0146amerikas.<\/p>\n

Komiteja izv\u0113l\u0113j\u0101s Isis de Oliveiru, un vi\u0146a iepaz\u012bstin\u0101ja ar savu p\u0113t\u012bjumu par zikas v\u012brusa iedarb\u012bbas sek\u0101m.<\/p>\n

\"zin\u0101tnisk\u0101
Isis de Oliveira iepaz\u012bstina ar rezult\u0101tiem<\/figcaption><\/figure>\n

Vi\u0146a uzrakst\u012bja ierakstu, kur\u0101 pateic\u0101s savai universit\u0101tei un stipendijai, kas vi\u0146ai \u013c\u0101va stud\u0113t. Turkl\u0101t vi\u0146a izteica cer\u012bbu, ka n\u0101kamajai paaudzei b\u016bs iesp\u0113jas turpin\u0101t zin\u0101tnieka karjeru, k\u0101 tas bija vi\u0146ai.<\/p>\n

T\u0101p\u0113c m\u0113s v\u0113lamies apsveikt Isis par vi\u0146as apbr\u012bnojamo darbu! Es ceru, ka vi\u0146a ar savu darbu iedvesmos vair\u0101k cilv\u0113ku k\u013c\u016bt par zin\u0101tniekiem.<\/p>\n

Un, ja v\u0113laties datus padar\u012bt vizu\u0101l\u0101kus, lai lab\u0101k sazin\u0101tos zin\u0101tn\u0113, varat izm\u0113\u0123in\u0101t Mind the Graph:<\/p>\n

\"pr\u0101t\u0101<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Vienm\u0113r ir p\u0101rsteidzo\u0161i par\u0101d\u012bt m\u016bsu lietot\u0101ju zin\u0101tnisko darbu. T\u0101p\u0113c \u0161odien es iepaz\u012bstin\u0101\u0161u j\u016bs ar Braz\u012blijas zin\u0101tnieci Isis de Souza un vi\u0146as darbu ar zikas v\u012brusu. Isis un vi\u0146as kol\u0113\u0123i p\u0113ta Zikas v\u012brusa infekcijas ietekmi uz pel\u0113m agr\u012bn\u0101 dz\u012bves posm\u0101. Vi\u0146a ir ar\u012b mind the graph lietot\u0101ja, un uzvar\u0113t\u0101jas prezent\u0101cija ir [...]<\/p>","protected":false},"author":11,"featured_media":9080,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[40],"tags":[299,282,554,71,775,293,316,315],"yoast_head":"\nZika virus: the award-winning study that sheds light on the future<\/title>\n<meta name=\"description\" content=\"Microcephaly is a known effect related to congenital exposure to zika virus. 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