{"id":8728,"date":"2019-04-23T16:35:01","date_gmt":"2019-04-23T19:35:01","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8728"},"modified":"2022-10-18T08:23:59","modified_gmt":"2022-10-18T11:23:59","slug":"visual-abstract-example","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/visual-abstract-example\/","title":{"rendered":"Lietot\u0101ja izveidots vizu\u0101ls kopsavilkums, lai izskaidrotu p\u0113t\u012bjuma \"Optimized Small-Molecule Pull-Downs Define MLBP1 as an Acyl-Lipid-Binding Protein\", ko sarakst\u012bjusi Je\u013cena Sterli\u0146a (Yelena Sterlin)."},"content":{"rendered":"<p style=\"text-align: justify;\">Vizu\u0101lo abstrakciju nav viegli izveidot, ta\u010du t\u0101 ir palikusi. T\u0101p\u0113c mums vienm\u0113r pat\u012bk par\u0101d\u012bt m\u016bsu lietot\u0101ju p\u0101rsteidzo\u0161os darbus k\u0101 iedvesmojo\u0161u vizu\u0101l\u0101s abstrakcijas piem\u0113ru. M\u0113s v\u0113lamies dot iesp\u0113ju zin\u0101tniekiem veidot vizu\u0101l\u0101ku un sasniedzam\u0101ku zin\u0101tni.<\/p>\n<p style=\"text-align: justify;\">\u0160aj\u0101 rakst\u0101 es jums par\u0101d\u012b\u0161u nelielu da\u013cu no s\u0101kotn\u0113j\u0101 p\u0113t\u012bjuma, ko veica&nbsp;<a href=\"https:\/\/www.researchgate.net\/profile\/Yelena_Sterlin2\" target=\"_blank\" rel=\"noopener\">Je\u013cena Sterli\u0146a<\/a> un kol\u0113\u0123iem. Vi\u0146a ir doktorant\u016bras studente Jeruzalemes Ebreju Universit\u0101tes Lauksaimniec\u012bbas, p\u0101rtikas un vides fakult\u0101t\u0113.<\/p>\n<p style=\"text-align: justify;\">Vi\u0146as jaunais raksts&nbsp;<a href=\"https:\/\/www.researchgate.net\/publication\/330976296_Optimized_Small-Molecule_Pull-Downs_Define_MLBP1_as_an_Acyl-Lipid-Binding_Protein\" target=\"_blank\" rel=\"noopener\">Optimiz\u0113ti mazmolekul\u0101ri Pull-Downs defin\u0113 MLBP1 k\u0101 acil-lip\u012bdu saisto\u0161u prote\u012bnu<\/a><strong>&nbsp;<\/strong>izgaismo olbaltumvielu un metabol\u012btu mijiedarb\u012bbu augos, \u012bpa\u0161u uzman\u012bbu piev\u0113r\u0161ot abscis\u012bnsk\u0101bes (ABA) receptoriem. Vi\u0146a ir ar\u012b pr\u0101ta grafiku abonente, t\u0101p\u0113c vi\u0146a izveidoja infografiku, kur\u0101 <a href=\"https:\/\/mindthegraph.com\">\u0146emiet v\u0113r\u0101 grafiku<\/a> izskaidrot savu metodolo\u0123iju.<\/p>\n<h2 style=\"text-align: center;\"><strong>Ar START dom\u0113nu saist\u012bto olbaltumvielu noz\u012bme<\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\">Saska\u0146\u0101 ar <a href=\"https:\/\/www.nature.com\/articles\/s41598-018-22538-9\" target=\"_blank\" rel=\"noopener\">Dabas \u017eurn\u0101ls<\/a>abscis\u012bnsk\u0101be (ABA) ir galvenais fitohormons, kas iesaist\u012bts abiotisk\u0101 stresa reakcij\u0101 un adapt\u0101cij\u0101. T\u0101 ir ar\u012b viens no agro\u0137\u012bmiskajiem kandid\u0101tiem.  ABA pirmo reizi tika atkl\u0101ta pag\u0101ju\u0161\u0101 gadsimta 60. gados. P\u0113c tam tika konstat\u0113ts, ka t\u0101 ir galvenais regulators t\u0101dos da\u017e\u0101dos procesos k\u0101 miera st\u0101voklis, d\u012bgtsp\u0113ja, d\u012bgtsp\u0113ja, s\u0113klu att\u012bst\u012bba un reakcija uz biotisko un abiotisko stresu.<\/p>\n<p style=\"text-align: justify;\">Agr\u0101kie notikumi, kas saist\u012bti ar ABA signaliz\u0101cijas ce\u013cu, ietver ABA saist\u012b\u0161anos ar PYR\/PYL\/RCARs receptoriem. \u0160ie receptori pieder pie START-dom\u0113nu super\u0123imenes.<\/p>\n<p style=\"text-align: justify;\">START olbaltumvielu dom\u0113ni ir lip\u012bdus saisto\u0161s dom\u0113ns, kas sastopams bakt\u0113riju, protistu, rauga, augu un dz\u012bvnieku genomos. Tom\u0113r tie bie\u017e\u0101k sastopami augos. Saska\u0146\u0101 ar<a href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/gb-2004-5-6-r41\" target=\"_blank\" rel=\"noopener\"> Schrick<\/a>, START dom\u0113nu kl\u0101tb\u016btne evol\u016bcijas zi\u0146\u0101 att\u0101l\u0101s sug\u0101s, piem\u0113ram, dz\u012bvniekos un augos, liecina, ka prote\u012bnu mijiedarb\u012bbas meh\u0101nisms ar lip\u012bdiem\/steroliem ir saglab\u0101jies.<\/p>\n<p style=\"text-align: justify;\">Dokuments public\u0113ts <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30735592\" target=\"_blank\" rel=\"noopener\">Augu \u017eurn\u0101ls<\/a> piev\u0113r\u0161as PYR\/PYL\/RCAR ABA receptoriem.  P\u0113tnieki nol\u0113ma optimiz\u0113t metodi, kas \u013cautu identific\u0113t START dom\u0113na un ar START dom\u0113nu saist\u012bto prote\u012bnu ligandus augos, jo<em>&nbsp;\"START dom\u0113na olbaltumvielu ligandi ir nepiecie\u0161ami to olbaltumvielu pareizai funkcion\u0113\u0161anai gan dz\u012bvniekiem, gan augiem, un ir pier\u0101d\u012bts, ka augu START dom\u0113na olbaltumvielas ir iesaist\u012btas b\u016btiskos fiziolo\u0123iskos procesos\".<\/em><\/p>\n<h2 style=\"text-align: center;\"><strong>Metodolo\u0123ijas vizu\u0101lais kopsavilkums<\/strong><\/h2>\n<p>&nbsp;<\/p>\n<h4 style=\"text-align: center;\"><strong>Lai izskaidrotu savu metodolo\u0123iju, zin\u0101tnieki izveidoja infografiku ar diagrammu ilustr\u0101cij\u0101m. T\u0101 ir pievilc\u012bga un viegl\u0101k saprotama.&nbsp;<\/strong><\/h4>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\">Zem\u0101k redzamaj\u0101 infografik\u0101 par\u0101d\u012bta eksperiment\u0101l\u0101 darba pl\u016bsma. K\u0101 redzams, tika izspiesti un att\u012br\u012bti \u010detri START prote\u012bni. Vi\u0146i filtr\u0113ja un inkub\u0113ja supernatantu, kas satur dab\u012bgo \u0161\u0137\u012bsto\u0161o frakciju, izmantojot streptavid\u012bna sef\u0101zi, afinit\u0101tes sve\u0137us, kas nodro\u0161ina dro\u0161u un augstu \u0161\u0137\u012bsto\u0161o frakciju.<wbr>-iz\u0161\u0137irtsp\u0113jas biomolekulu att\u012br\u012b\u0161ana. P\u0113c tam vi\u0146i analiz\u0113ja alikvotus, izmantojot Western blot. Lai identific\u0113tu ligandu, vi\u0146i elu\u0113ja iesp\u0113jamos ligandus un veica LC-MS (\u0161\u0137idruma hromatogr\u0101fijas un masspektrometrijas) sist\u0113mas anal\u012bzi. Ar tand\u0113mmasspektrometrijas metodi tika noteikta interes\u0113jo\u0161o iesp\u0113jamo ligandu molekul\u0101r\u0101 strukt\u016bra.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-8735 size-full\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/04\/yelena.png\" alt=\"yelena sterlin vizu\u0101l\u0101 abstrakcija \" width=\"610\" height=\"650\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/04\/yelena.png 610w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/04\/yelena-282x300.png 282w\" sizes=\"(max-width: 610px) 100vw, 610px\" \/><\/p>\n<p style=\"text-align: justify;\">Autori iepaz\u012bstin\u0101ja ar labu tehniku prote\u012bnu ligandu s\u0101kotn\u0113jai izp\u0113tei augos. Vi\u0146i piel\u0101goja pieeju, lai atkl\u0101tu START ligandus. Tom\u0113r, piel\u0101gojot anal\u012btiskos apst\u0101k\u013cus, metodi var piel\u0101got da\u017e\u0101das \u0137\u012bmisk\u0101s dabas ligandiem.<\/p>\n<p style=\"text-align: justify;\">Ja v\u0113laties par\u0101d\u012bt savu p\u0113t\u012bjumu, izmantojot zin\u0101tniskas ilustr\u0101cijas un vizu\u0101lus kopsavilkumus, varat izmantot ar\u012b Mind the Graph. T\u0101tad, vai esat gatavs uzlabot savu komunik\u0101ciju zin\u0101tn\u0113?<\/p>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/mindthegraph.com\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-6577 size-full\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2017\/01\/start_get-mind-the-graph-medical-illustrations.png\" alt=\"priek\u0161skat\u012bjums_250\" width=\"310\" height=\"100\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2017\/01\/start_get-mind-the-graph-medical-illustrations.png 310w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2017\/01\/start_get-mind-the-graph-medical-illustrations-300x97.png 300w\" sizes=\"(max-width: 310px) 100vw, 310px\" \/><\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Vizu\u0101lo abstrakciju nav viegli izveidot, ta\u010du t\u0101 ir palikusi. T\u0101p\u0113c mums vienm\u0113r pat\u012bk par\u0101d\u012bt m\u016bsu lietot\u0101ju p\u0101rsteidzo\u0161os darbus k\u0101 iedvesmojo\u0161u vizu\u0101l\u0101s abstrakcijas piem\u0113ru. M\u0113s v\u0113lamies dot iesp\u0113ju zin\u0101tniekiem veidot vizu\u0101l\u0101ku un sasniedzam\u0101ku zin\u0101tni. \u0160aj\u0101 rakst\u0101 es jums par\u0101d\u012b\u0161u nedaudz no [...]<\/p>","protected":false},"author":11,"featured_media":8741,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[193,40],"tags":[291,96,292,245,294,295,554,775,293,382],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Visual abstract created by Mind the Graph user. 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