{"id":8713,"date":"2019-04-18T18:07:31","date_gmt":"2019-04-18T21:07:31","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8713"},"modified":"2022-10-18T08:24:00","modified_gmt":"2022-10-18T11:24:00","slug":"brain-damage-pig-brains-alive-hours-death","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/smadzenu-bojajumi-cuku-smadzenes-dzivo-stundas-mirst\/","title":{"rendered":"Smadze\u0146u boj\u0101jumi: infografika, lai izprastu jauno Nature rakstu"},"content":{"rendered":"

Jeila Universit\u0101tes zin\u0101tnieki vair\u0101kas stundas p\u0113c n\u0101ves tur\u0113ja c\u016bku smadzenes dz\u012bvas \u0101rpus \u0137erme\u0146a. Dokument\u0101 Smadze\u0146u asinsrites un \u0161\u016bnu funkciju atjauno\u0161ana vair\u0101kas stundas p\u0113c n\u0101ves<\/strong> skaidro eksperimentu, kur\u0101 izmantotas c\u016bku smadzenes, kas var dot ieskatu smadze\u0146u boj\u0101jumu izp\u0113t\u0113. \u017durn\u0101ls Nature\u00a0public\u0113ts <\/a>dokumentu 17. apr\u012bl\u012b.<\/p>\n

\"Liel\u0101ko da\u013cu cilv\u0113ces v\u0113stures n\u0101ve bija \u013coti vienk\u0101r\u0161a.\"<\/em> saka Kristofs Kochs. Vi\u0146\u0161 ir Allenas Smadze\u0146u zin\u0101tnes instit\u016bta Sietl\u0101, Va\u0161ingtonas \u0161tat\u0101, prezidents un galvenais zin\u0101tnieks. \"Tagad mums ir j\u0101jaut\u0101, kas ir neatgriezenisks.\"\u00a0<\/em><\/p>\n

\u0160aj\u0101s smadzen\u0113s starp neironiem nenotiek nek\u0101da komunik\u0101cija, t\u0101p\u0113c taj\u0101s nebija apzi\u0146as. Ta\u010du \u0161\u016bnas bija dz\u012bvas, un tas vien ir \u013coti liels atkl\u0101jums.<\/p>\n

\"Iepriek\u0161 ieg\u016btie dati liecina, ka \u0161\u016bn\u0101s b\u016bt\u012bb\u0101 p\u0113c da\u017e\u0101m min\u016bt\u0113m notiek \u0161\u016bnu boj\u0101eja,\".<\/em>\u00a0preses konferenc\u0113 sac\u012bja Jeila universit\u0101tes neirozin\u0101tnieks Nenads Sestans, kur\u0161 vad\u012bja p\u0113t\u012bjumu. \"M\u0113s par\u0101d\u0101m, ka \u0161\u016bnu boj\u0101ejas process ir pak\u0101penisks, pak\u0101penisks process, un da\u017eus no \u0161iem procesiem var atlikt, saglab\u0101t vai pat aptur\u0113t.\"\"<\/em><\/p>\n

Smadze\u0146u boj\u0101jumu eksperiments<\/strong><\/h3>\n

Saska\u0146\u0101 ar Nature Magazine p\u0113tnieki p\u0101rbaud\u012bja, k\u0101 smadzenes darboj\u0101s se\u0161u stundu laik\u0101. Vi\u0146i konstat\u0113ja, ka neironi un citas smadze\u0146u \u0161\u016bnas bija ats\u0101ku\u0161as norm\u0101las vielmai\u0146as funkcijas, piem\u0113ram, cukura pat\u0113ri\u0146u un oglek\u013ca dioks\u012bda ra\u017eo\u0161anu. \u0160\u0137ita, ka darbojas ar\u012b smadze\u0146u im\u016bnsist\u0113ma. Atsevi\u0161\u0137u \u0161\u016bnu un smadze\u0146u da\u013cu strukt\u016bras bija saglab\u0101ju\u0161\u0101s. Turpret\u012b \u0161\u016bnas kontrolsmadzen\u0113s, kas nesa\u0146\u0113ma ar bar\u012bbas viel\u0101m un sk\u0101bekli bag\u0101to \u0161\u0137\u012bdumu, sabruka. Un, kad zin\u0101tnieki apstr\u0101d\u0101to smadze\u0146u audu paraugiem pielietoja elektr\u012bbu, vi\u0146i konstat\u0113ja, ka atsevi\u0161\u0137i neironi joproj\u0101m var\u0113ja p\u0101rraid\u012bt sign\u0101lu.<\/p>\n

Zin\u0101tnieki izveidoja sist\u0113mu ar nosaukumu BrainEx, kas ir \u012bpa\u0161i izstr\u0101d\u0101ta, lai v\u0101jin\u0101tu da\u017eus procesus, kas izraisa audu degrad\u0101ciju p\u0113cn\u0101ves smadzen\u0113s. Sist\u0113ma ietver \u0161\u0137\u012bduma, ko sauc par BEx perfuz\u0101tu, s\u016bkn\u0113\u0161anu. \u0160\u0137\u012bdums ir patent\u0113ts aizsarg\u0101jo\u0161u, stabiliz\u0113jo\u0161u un kontrastvielu mais\u012bjums, kas darbojas k\u0101 asins aizst\u0101j\u0113ji. Perf\u016bz\u0101ts satur ar\u012b \u0137\u012bmiskas vielas, kas aptur \u0137erme\u0146a audu oksid\u0101ciju, kas aptur apoptozi. Tas satur ar\u012b nervu aktivit\u0101tes blokatoru, kura m\u0113r\u0137is ir div\u0113j\u0101ds. Vi\u0146i iepild\u012bja \u0161\u0137\u012bdumu izol\u0113to smadze\u0146u galvenaj\u0101s art\u0113rij\u0101s norm\u0101l\u0101 \u0137erme\u0146a temperat\u016br\u0101.<\/p>\n

 <\/p>\n

\"c\u016bkas\"<\/a>
Raksta att\u0113l\u0101 redzams, k\u0101 pie BEx ier\u012bces tika piesl\u0113gtas veselas smadzenes. C\u016bkas smadze\u0146u piesl\u0113g\u0161ana perf\u016bzijas sist\u0113mai tika veikta, izmantojot arteri\u0101l\u0101s l\u012bnijas.\u00a0<\/strong><\/figcaption><\/figure>\n

 <\/p>\n

P\u0113tnieki izmantoja aptuveni 300 c\u016bku galvas no ASV Lauksaimniec\u012bbas departamenta kautuves. P\u0113c tehnolo\u0123ijas optimiz\u0113\u0161anas komanda savienoja 32 c\u016bku smadzenes ar BrainEx sist\u0113mu. Vi\u0146i to veica 4 stundas p\u0113c c\u016bku nogalin\u0101\u0161anas un p\u0113c tam, kad no galvaskausiem bija iz\u0146emtas smadzenes. \u0160is datoriz\u0113tais s\u016bk\u0146u, sild\u012bt\u0101ju un filtru t\u012bkls se\u0161as stundas kontrol\u0113ja pl\u016bsmu, temperat\u016bru un patent\u0113tu perfuz\u0101ta \u0161\u0137\u012bdumu.<\/p>\n

Infografika eksperimenta izpratnei<\/strong><\/h2>\n

 <\/p>\n

\"preview_77833<\/a><\/p>\n

 <\/p>\n

\u0160o infografiku izveidoju, izmantojot Mind the Graph. Ja v\u0113laties izmantot pievilc\u012bgas zin\u0101tniskas ilustr\u0101cijas, lai ar savu p\u0113t\u012bjumu sasniegtu vair\u0101k cilv\u0113ku, varat izmantot ar\u012b mind the Graph!<\/p>\n

\"priek\u0161skat\u012bjums_250\"<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Jeila Universit\u0101tes zin\u0101tnieki vair\u0101kas stundas p\u0113c n\u0101ves tur\u0113ja c\u016bku smadzenes dz\u012bvas \u0101rpus \u0137erme\u0146a. Darb\u0101 \"Smadze\u0146u asinsrites un \u0161\u016bnu funkciju atjauno\u0161ana stundas p\u0113c n\u0101ves\" skaidrots eksperiments, kur\u0101 izmantotas c\u016bku smadzenes, kas var ienest gaismu smadze\u0146u boj\u0101jumu p\u0113tniec\u012bb\u0101. \u017durn\u0101ls Nature public\u0113ja \u0161o darbu 17. apr\u012bl\u012b. \"Liel\u0101ko da\u013cu cilv\u0113ces v\u0113stures n\u0101ve bija \u013coti vienk\u0101r\u0161a,\" [...]<\/p>","protected":false},"author":11,"featured_media":8721,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[54,288,287,286,282,554,71,964,775,70],"yoast_head":"\nBrain damage: an infographic to understand the new Nature paper - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Scientists from Yale University kept pig brains alive for hours after death. 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