{"id":8527,"date":"2019-03-20T18:17:14","date_gmt":"2019-03-20T21:17:14","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8527"},"modified":"2022-10-19T10:38:06","modified_gmt":"2022-10-19T13:38:06","slug":"nature-neuroscience","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/daba-neirologija\/","title":{"rendered":"Nature neirozin\u0101tne: saikne starp \u0161izofr\u0113niju un mikrogliju."},"content":{"rendered":"

\u0160izofr\u0113nija ir hronisks un smags gar\u012bgs trauc\u0113jums, kas ietekm\u0113 cilv\u0113ka dom\u0101\u0161anu, j\u016btas un uzved\u012bbu. Cilv\u0113kiem ar \u0161izofr\u0113niju var \u0161\u0137ist, ka vi\u0146i ir zaud\u0113ju\u0161i saikni ar realit\u0101ti. Lai izprastu \u0161izofr\u0113nijas att\u012bst\u012bbu, mums ir j\u0101run\u0101 par sinaptisko atzaro\u0161anu. Saska\u0146\u0101 ar rakstu no Nature neirozin\u0101tnes 1<\/sup>, “sinapses atzaro\u0161ana ir sinapses likvid\u0113\u0161anas process, kas notiek agr\u0101 b\u0113rn\u012bb\u0101 l\u012bdz agrai pieaugu\u0161o vecumam.\"<\/em> Smadzen\u0113m att\u012bstoties, vides ietekme ietekm\u0113 veidojas nervu sh\u0113mas. \u0160is process likvid\u0113 lieko sinapses, kas rad\u0101s agr\u012bn\u0101s att\u012bst\u012bbas laik\u0101, un nostiprina atliku\u0161\u0101s sinapses.<\/p>\n\n\n\n

Turkl\u0101t saska\u0146\u0101 ar \"sinaptisk\u0101s atzaro\u0161anas\" hipot\u0113zi p\u0101rm\u0113r\u012bga vai trauc\u0113ta sinaptisk\u0101 atzaro\u0161ana ir saist\u012bta ar \u0161izofr\u0113nijas trauc\u0113jumiem. \u0160o hipot\u0113zi 1982. gad\u0101 izvirz\u012bja psihiatrs Irvins Feinbergs.<\/p>\n\n\n\n

Turkl\u0101t pirms da\u017eiem gadiem cilv\u0113ku smadze\u0146u att\u0113lveido\u0161anas un p\u0113cn\u0101ves p\u0113t\u012bjumi sniedza jaunus pier\u0101d\u012bjumus, kas apstiprina \"sinaptisk\u0101s atzaro\u0161anas\" hipot\u0113zi. Pier\u0101d\u012bjumi liecin\u0101ja, ka \u0161izofr\u0113nijas pacientu garoz\u0101 ir samazin\u0101ts mugurkaula bl\u012bvums un pel\u0113k\u0101 viela.
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\"priek\u0161skat\u012bjums_69596<\/a><\/figure><\/div>\n\n\n

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Vai esat gatavs s\u0101kt str\u0101d\u0101t ar Mind the Graph?<\/a><\/div>\n<\/div>\n\n\n\n

 Jauni pier\u0101d\u012bjumi public\u0113ti \u017eurn\u0101l\u0101 Nature neirozin\u0101tne:<\/strong><\/h3>\n\n\n\n

T\u0101p\u0113c tagad zin\u0101tnieki cen\u0161as izprast meh\u0101nismu, kas ir \u0161\u012bs par\u0101d\u012bbas pamat\u0101. P\u0113c Karla Sellgr\u0113na, Roja Perlisa un vi\u0146u kol\u0113\u0123u dom\u0101m, im\u016bnsist\u0113mai var b\u016bt zin\u0101ma loma p\u0101rm\u0113r\u012bg\u0101 sinapses atzaro\u0161an\u0101. Vi\u0146u jaunais raksts1<\/sup> \u017eurn\u0101l\u0101 Nature neiroscience public\u0113taj\u0101 p\u0113t\u012bjum\u0101 aprakst\u012bts in vitro modelis, kur\u0101 \u0161\u016bnu p\u0101rprogramm\u0113\u0161ana tiek izmantota, lai p\u0113t\u012btu \u0161izofr\u0113nijas pacientiem specifisku mikroglijas medi\u0113tu sinapses uzs\u016bk\u0161anos.<\/p>\n\n\n\n

Mikroglijas ir kop\u012bgs neirogliju (glijas \u0161\u016bnu) veids, kas atrodas galvas un muguras smadzen\u0113s un muguras smadzen\u0113s. T\u0101s ir 10-15% no vis\u0101m galvas smadzen\u0113s atrodamaj\u0101m \u0161\u016bn\u0101m. K\u0101 rezid\u0113jo\u0161\u0101s makrof\u0101gu \u0161\u016bnas t\u0101s darbojas k\u0101 pirmais un galvenais akt\u012bv\u0101s im\u016bn\u0101s aizsardz\u012bbas veids centr\u0101laj\u0101 nervu sist\u0113m\u0101 (CNS). Turkl\u0101t mikroglijas \u0161\u016bnas sp\u0113j atpaz\u012bt sve\u0161\u0137erme\u0146us, nor\u012bt tos un darboties k\u0101 antig\u0113nu prezent\u0113jo\u0161\u0101s \u0161\u016bnas, aktiviz\u0113jot T-\u0161\u016bnas.<\/p>\n\n\n

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\"priek\u0161skat\u012bjums_69544\"<\/a><\/figure><\/div>\n\n
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\"preview_69618\"<\/a><\/figure><\/div>\n\n
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\"preview_69620\"<\/a><\/figure><\/div>\n\n\n
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S\u0101ciet veidot Mind the Graph jau tagad<\/a><\/div>\n<\/div>\n\n\n\n

Turpiniet las\u012bt par neirozin\u0101tnes t\u0113m\u0101m<\/h2>\n\n\n\n