{"id":7891,"date":"2018-05-27T16:44:24","date_gmt":"2018-05-27T19:44:24","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=7891"},"modified":"2022-10-18T14:37:51","modified_gmt":"2022-10-18T17:37:51","slug":"cystic-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/cistiska-fibroze\/","title":{"rendered":"Cistisk\u0101s fibrozes apzin\u0101\u0161an\u0101s m\u0113nesis"},"content":{"rendered":"

Maijs ir cistisk\u0101s fibrozes apzin\u0101\u0161an\u0101s m\u0113nesis. Cistisk\u0101 fibroze (CF) ir autosom\u0101li reces\u012bva \u0123en\u0113tiska slim\u012bba. CF izraisa mut\u0101cijas g\u0113n\u0101, kas kod\u0113 cistisk\u0101s fibrozes transmembr\u0101nas vad\u012btsp\u0113jas regulatora (CFTR) kan\u0101lu. \u0160is prote\u012bns ir atbild\u012bgs par jonu p\u0101rneses vari\u0101cij\u0101m caur \u0161\u016bnu membr\u0101n\u0101m.<\/p>\n\n\n\n

Saska\u0146\u0101 ar \u0123en\u0113tikas m\u0101jas atsauksm\u0113m 1<\/sup>, CFTR g\u0113ns nodro\u0161ina nor\u0101d\u012bjumus prote\u012bna, ko sauc par cistisk\u0101s fibrozes transmembr\u0101nas vad\u012btsp\u0113jas regulatoru, ra\u017eo\u0161anai:<\/p>\n\n\n\n

\u0160is prote\u012bns darbojas k\u0101 kan\u0101ls caur \u0161\u016bnu membr\u0101nu, kas ra\u017eo g\u013cotas, sviedrus, siekalas, asaras un gremo\u0161anas fermentus. Kan\u0101ls transport\u0113 negat\u012bvi l\u0101d\u0113tas da\u013ci\u0146as, ko sauc par hlor\u012bda joniem, uz \u0161\u016bn\u0101m un no t\u0101m. Hlor\u012bda jonu p\u0101rnese pal\u012bdz kontrol\u0113t \u016bdens kust\u012bbu audos, kas ir nepiecie\u0161ama pl\u0101nu, br\u012bvi pl\u016bsto\u0161u g\u013cotu ra\u017eo\u0161anai. G\u013cotas ir slidenas vielas, kas e\u013c\u013co un aizsarg\u0101 elpce\u013cu, gremo\u0161anas sist\u0113mas, reprodukt\u012bv\u0101s sist\u0113mas un citu org\u0101nu un audu g\u013cot\u0101das.<\/p>\n\n\n\n

CFTR prote\u012bns regul\u0113 ar\u012b citu kan\u0101lu darb\u012bbu, piem\u0113ram, t\u0101du, kas caur \u0161\u016bnu membr\u0101n\u0101m transport\u0113 pozit\u012bvi l\u0101d\u0113tas da\u013ci\u0146as, t.s. n\u0101trija jonus. \u0160ie kan\u0101li ir nepiecie\u0161ami norm\u0101lai t\u0101du org\u0101nu k\u0101 plau\u0161u un aizku\u0146\u0123a dziedzera darb\u012bbai.<\/span><\/p>\n\n\n

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\"dfaefqawefafc\"<\/a><\/figure><\/div>\n\n\n

Tas ietekm\u0113 eksokr\u012bno dziedzeru darb\u012bbu, radot biez\u0101kas, gr\u016bti izvad\u0101mas vielas (g\u013cotas, sviedrus vai aizku\u0146\u0123a dziedzera fermentus).
T\u0101d\u0113\u013c cistisk\u0101 fibroze ietekm\u0113 gremo\u0161anas un elpo\u0161anas sist\u0113mu un sviedru dziedzerus.<\/p>\n\n\n\n

Tom\u0113r slim\u012bba visvair\u0101k skar elpo\u0161anas sist\u0113mu. Plau\u0161\u0101s veidojas biezas g\u013cotas, kas var iespr\u016bst elpce\u013cos. Pacientiem ar cistisko fibrozi var att\u012bst\u012bties hroniskas bakteri\u0101las plau\u0161u infekcijas un iekaisums, kas galu gal\u0101 var izrais\u012bt plau\u0161u slim\u012bbas beigu stadiju.
Citi simptomi ir klepus ar sekr\u0113ciju, atk\u0101rtota pneimonija un hronisks bronh\u012bts.<\/p>\n\n\n\n

Sieviet\u0113m ar CF ir gr\u016bt\u0101k iest\u0101ties gr\u016btniec\u012bbai, jo biez\u0101kas dzemdes kakla g\u013cotas apgr\u016btina spermas iek\u013c\u016b\u0161anu. V\u012brie\u0161iem tas ir v\u0113l gr\u016bt\u0101k. Aptuveni 98% v\u012brie\u0161u ir neaugl\u012bgi, lai gan vi\u0146iem ir piln\u012bgi norm\u0101la dzimumsp\u0113ja un potence.<\/p>\n\n\n\n

Es izv\u0113l\u0113jos 3 CF saites, lai dal\u012btos ar jums \u0161odien.<\/p>\n\n\n\n

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Efekt\u012bvu zin\u0101tnisko fig\u016bru izveide da\u017eu min\u016b\u0161u laik\u0101<\/a><\/div>\n<\/div>\n\n\n\n

Laba komunik\u0101cija, kas demistific\u0113 cistisko fibrozi<\/h3>\n\n\n\n
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