{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/autofagija-iegust-nobela-premiju-medicina\/","title":{"rendered":"Nobela pr\u0113mija medic\u012bn\u0101 par autof\u0101\u0123iju"},"content":{"rendered":"

Autof\u0101gijas process ir saist\u012bts ar vair\u0101k\u0101m slim\u012bb\u0101m, piem\u0113ram, v\u0113zi un neirolo\u0123isk\u0101m slim\u012bb\u0101m. Tas darbojas k\u0101 organisma iek\u0161\u0113j\u0101 p\u0101rstr\u0101des programma. Tom\u0113r autof\u0101gijas darb\u012bbas trauc\u0113jumi ir saist\u012bti ar Parkinsona slim\u012bbu, diab\u0113tu, v\u0113zi un citiem ar vecumu saist\u012btiem trauc\u0113jumiem.<\/p>\n

P\u0113c \u0161\u012b neliel\u0101 ievada par autof\u0101\u0123ijas procesa noz\u012bmi nav nek\u0101ds p\u0101rsteigums, ka par jauniem atkl\u0101jumiem \u0161aj\u0101 jom\u0101 var sa\u0146emt Nobela pr\u0113miju. Patie\u0161\u0101m, pag\u0101ju\u0161aj\u0101 pirmdien\u0101 p\u0113tniece Yoshino Ohsumi sa\u0146\u0113ma Nobela pr\u0113mija medic\u012bn\u0101<\/a> lai noteiktu pirmos autof\u0101\u0123ijai b\u016btiskos g\u0113nus.<\/p>\n

\"Es nej\u016btos komfortabli, sacen\u0161oties ar daudziem cilv\u0113kiem, un man pat\u012bkam\u0101k ir dar\u012bt kaut ko t\u0101du, ko neviens cits nedara. Sav\u0101 zi\u0146\u0101 tie\u0161i tas ir zin\u0101tne, un prieks, ko sniedz tas, ka es kaut ko atkl\u0101ju, mani iedvesmo.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

K\u0101 Ohsumi to izdar\u012bja?<\/h3>\n

Sav\u0101 laboratorij\u0101 Ohsumi bija rad\u012bjis rauga celmus, kas bada laik\u0101 uzkr\u0101j autofagosomas. \u0160\u0101da akumul\u0101cija var\u0113ja notikt tikai tad, ja autofagijai b\u016btiski g\u0113ni bija neakt\u012bvi. T\u0101d\u0113j\u0101di Ohsumi s\u0101ka manipul\u0113t ar \u0161\u016bn\u0101m, izmantojot vair\u0101kas g\u0113nu mut\u0101cijas, un vi\u0146am izdev\u0101s izrais\u012bt autofagiju.<\/p>\n

\"Nobela<\/a><\/p>\n

Autof\u0101gija ir paz\u012bstama jau kop\u0161<\/h3>\n

Lai gan autof\u0101gija ir zin\u0101ma jau 50 gadus, tikai 90. gados, pateicoties Ohsumi p\u0113t\u012bjumiem, tika atz\u012bta \u0161\u012b procesa noz\u012bme.
\nPar savu darbu Ohsumi jau ir nopeln\u012bjis da\u017eus fanus:<\/p>\n

\"Nobela<\/a><\/p>\n

\n

\"Es \u013coti priec\u0101jos, ka vi\u0146\u0161 \u0161ogad sa\u0146\u0113ma Nobela pr\u0113miju, t\u0101 ir \u013coti peln\u012bta. Vi\u0146a laboratorija galvenok\u0101rt str\u0101d\u0101 ar raugu. Vi\u0146i veica s\u0101kotn\u0113jos skr\u012bningus, kas \u013c\u0101va atkl\u0101t galvenos g\u0113nus, kuri ir iesaist\u012bti autof\u0101gij\u0101. Tik daudzas citas laboratorijas ir tie\u0161i vai netie\u0161i izmantoju\u0161as vi\u0146a atkl\u0101jumus, lai noskaidrotu, k\u0101p\u0113c tas ir svar\u012bgi slim\u012bbu gad\u012bjumos.\"<\/p>\n

David Rubinsztein<\/a> - Kembrid\u017eas Medic\u012bnas p\u0113t\u012bjumu instit\u016bta direktora vietnieks.<\/p>\n<\/blockquote>\n

\"Nobela<\/a><\/p>\n

\n

\"Manupr\u0101t, ir \u013coti svar\u012bgi, lai \u0161\u012b zin\u0101tnes joma tiktu atz\u012bta. Svar\u012bgs princips \u0161eit ir mekl\u0113t kop\u012bgus meh\u0101nismus slim\u012bbu gad\u012bjum\u0101. Tas paver iesp\u0113jas \u0161o trauc\u0113jumu \u0101rst\u0113\u0161anai, kas at\u0161\u0137iras no tradicion\u0101l\u0101m, konkr\u0113t\u0101m slim\u012bb\u0101m rakstur\u012bg\u0101m pieej\u0101m.\"<\/p>\n

Giovanna Mallucci<\/a> - Kembrid\u017eas Universit\u0101tes kl\u012bnisk\u0101s neirozin\u0101tnes profesors.<\/p>\n<\/blockquote>\n

\"Nobela<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Autof\u0101\u0123ijas process ir iesaist\u012bts vair\u0101kos st\u0101vok\u013cos, piem\u0113ram, v\u0113\u017ea un neirolo\u0123isku slim\u012bbu gad\u012bjumos. Tas darbojas k\u0101 organisma iek\u0161\u0113j\u0101 p\u0101rstr\u0101des programma. Tom\u0113r autof\u0101gijas darb\u012bbas trauc\u0113jumi ir saist\u012bti ar Parkinsona slim\u012bbu, diab\u0113tu, v\u0113zi un citiem ar vecumu saist\u012btiem trauc\u0113jumiem. P\u0113c \u0161\u012b neliel\u0101 ievada par autof\u0101\u0123ijas procesa noz\u012bmi nav p\u0101rsteigums, ka jaunie atkl\u0101jumi [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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