{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/success-case-nuclear-receptors-in-liver-fibrosis\/","title":{"rendered":"Kodola receptori aknu fibroz\u0113 Pap\u012bra p\u0101rskats"},"content":{"rendered":"

\u0160aj\u0101 gad\u012bjum\u0101 autors izmantoja Mind the Graph, lai apkopotu datus no da\u017e\u0101diem avotiem vienuviet. Papildus lab\u0101kaj\u0101m zin\u0101tniski prec\u012bzaj\u0101m ilustr\u0101cij\u0101m m\u016bsu darba vietai ir draudz\u012bga saskarne, un to ir \u013coti viegli izmantot.<\/p>\n\n\n\n

P\u0101rbaudiet pilnu ori\u0123in\u0101lais raksts<\/a>. <\/p>\n\n\n\n

Kodolreceptoru loma aknu fibroz\u0113<\/strong><\/h2>\n\n\n\n

Philipp K\u00f6nigshofer et al. (2021) zi\u0146o, ka kodolreceptori ir ligandu aktiviz\u0113ti transkripcijas faktori, kas regul\u0113 g\u0113nu ekspresiju da\u017e\u0101diem galvenajiem molekul\u0101rajiem sign\u0101liem, kas saist\u012bti ar aknu fibrozi. <\/p>\n\n\n\n

Aknu fibro\u0123en\u0113zes galvenais \u0161\u016bnu virz\u012bt\u0101jsp\u0113ks ir aktiv\u0113tas aknu stell\u0101t\u0101s \u0161\u016bnas. Da\u017e\u0101di kodolreceptori regul\u0113 proiekaisuma un pro-fibrog\u0113nu citok\u012bnu ekspresiju akn\u0101s.<\/p>\n\n\n\n

Grafiskie kopsavilkumi, ko nodro\u0161ina Mind the Graph<\/strong> \u0161aj\u0101 pant\u0101<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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\"\"<\/a>
Izgatavots ar Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n
<\/div>\n\n\n\n

Pirmais att\u0113ls ir kodolreceptoru apskats un klasifik\u0101cija pa apak\u0161\u0123imen\u0113m.<\/p>\n\n\n\n

<\/div>\n\n\n
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\"\"<\/a>
Izgatavots ar Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Virs teksta redzamas da\u017e\u0101das kodolreceptoru efektoru funkcijas.<\/p>\n\n\n\n

<\/div>\n\n\n
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\"\"<\/a>
Izgatavots ar Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Tre\u0161aj\u0101 att\u0113l\u0101 ir sniegts p\u0101rskats par NR modul\u0101ciju k\u0101 potenci\u0101lo terapeitisko pieeju aknu slim\u012bbu \u0101rst\u0113\u0161anai. <\/p>\n\n\n\n

Ar bulti\u0146\u0101m nor\u0101d\u012bta iesp\u0113jam\u0101 labv\u0113l\u012bg\u0101 ietekme uz aknu slim\u012bb\u0101m, ko rada uz aug\u0161u - (tum\u0161i za\u013ca)<\/strong><\/span> vai uz leju (gai\u0161i za\u013c\u0161)<\/span><\/strong> specifisku meh\u0101nismu regul\u0113\u0161ana, kas, k\u0101 zi\u0146ots, veicina aknu fibrozes regresiju vai samazina aknu fibrozi. <\/p>\n\n\n\n

Oran\u017e\u0101s bultas<\/mark><\/strong> nor\u0101da uz NR modul\u0101cijas ietekmi un meh\u0101nismiem, kas ir vai nu pretrun\u012bgi, vai ar\u012b v\u0113l nav pietiekami nov\u0113rt\u0113ti.<\/p>\n\n\n\n

<\/div>\n\n\n
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\"\"<\/a>
Izgatavots ar Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

P\u0113d\u0113j\u0101 att\u0113l\u0101 att\u0113lota NR modulatoru molekul\u0101r\u0101 iedarb\u012bba k\u0101 potenci\u0101la aknu fibrozes \u0101rst\u0113\u0161anas metode, kas, k\u0101 zi\u0146ots, p\u0101rsvar\u0101 notiek HSC.<\/p>\n\n\n\n

K\u0113nigshofers un kol\u0113\u0123i ierosina, ka turpm\u0101ka ar kodolreceptoriem saist\u012bto sign\u0101lu izp\u0113te var novest pie efekt\u012bvas pretfibrotisk\u0101s terapijas izstr\u0101des pacientiem ar aknu slim\u012bb\u0101m.<\/p>\n\n\n\n

Dokumenti Ietekme un veiktsp\u0113ja<\/strong><\/h2>\n\n\n\n

Izv\u0113loties viena gada iesp\u0113ju sal\u012bdzin\u0101t r\u0101d\u012bt\u0101jus ar citiem rakstiem\/p\u0101rskatiem, kas ar\u012b public\u0113ti taj\u0101 pa\u0161\u0101 kalend\u0101raj\u0101 gad\u0101 min\u0113taj\u0101 \u017eurn\u0101l\u0101, var paman\u012bt, ka \u0161is raksts tika cit\u0113ts vair\u0101k nek\u0101 57% no tiem<\/strong>.<\/p>\n\n\n

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\"\"<\/a>
Avots: PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Izmantojiet infografikas iesp\u0113jas, lai uzlabotu ar\u012b savu rakstu. Izm\u0113\u0123iniet Mind the Graph!<\/p>\n\n\n\n

\n
Izm\u0113\u0123iniet Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\u0160aj\u0101 rakst\u0101 ir zin\u0101tniskas ilustr\u0101cijas, kas veidotas ar Mind the Graph, lai att\u0113lotu kodolreceptorus aknu fibroz\u0113.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nNuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/lv\/success-case-nuclear-receptors-in-liver-fibrosis\/\" \/>\n<meta property=\"og:locale\" content=\"lv_LV\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/lv\/success-case-nuclear-receptors-in-liver-fibrosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-16T22:40:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nuclear receptors in liver fibrosis Paper Review - 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