{"id":16651,"date":"2022-09-12T18:50:00","date_gmt":"2022-09-12T21:50:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16651"},"modified":"2023-03-17T14:47:35","modified_gmt":"2023-03-17T17:47:35","slug":"success-case-immunotherapeutic-potential-of-crotoxin-anti-inflammatory-and-immunosuppressive-properties","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/veiksmes-gadijuma-imunterapijas-potencials-rotoksina-pretiekaisuma-un-imunsupresivo-ipasibu\/","title":{"rendered":"Krotoks\u012bna imunoterapeitiskais potenci\u0101ls: pretiekaisuma un im\u016bnsupres\u012bv\u0101s \u012bpa\u0161\u012bbas Paper Review"},"content":{"rendered":"<p>Bez atbilsto\u0161iem att\u0113liem var\u0113tu b\u016bt mazliet gr\u016bti izskaidrot krotoks\u012bna pretiekaisuma modul\u0101ciju, ta\u010du tie\u0161i t\u0101p\u0113c past\u0101v Mind the Graph!<\/p>\n\n\n\n<h2><strong>P\u0101rskats par zin\u0101tniskajiem p\u0113t\u012bjumiem par krotoks\u012bnu - grauz\u0113ja \u010d\u016bskas indi<\/strong><\/h2>\n\n\n\n<p>Marco Sartim et al. (2018) rakst\u0101 \"Krotoks\u012bna imunoterapeitiskais potenci\u0101ls\" (Immunotherapeutic potential of Crotoxin) nor\u0101da, ka p\u0113d\u0113jo 80 gadu laik\u0101 krotoks\u012bns ir k\u013cuvis par vienu no visvair\u0101k p\u0113t\u012btajiem izol\u0113tajiem \u010d\u016bsku indes toks\u012bniem. <\/p>\n\n\n\n<p>Krotoks\u012bns ir galven\u0101 toksisk\u0101 sast\u0101vda\u013ca Dienvidamerikas \u017eurku \u010d\u016bskas Crotalus durissus terrificus kod\u0113. P\u0113t\u012bjumi liecina, ka C.d.t. imunomodul\u0113jo\u0161\u0101 iedarb\u012bba ir saist\u012bta ar pretiekaisuma mediatoru veido\u0161anos. <\/p>\n\n\n\n<p>Krotoks\u012bna un t\u0101 apak\u0161vien\u012bbu sp\u0113ja modul\u0113t im\u016bnsist\u0113mu atkl\u0101ja jaunas perspekt\u012bvas k\u0101 potenci\u0101liem terapeitiskiem l\u012bdzek\u013ciem.<\/p>\n\n\n\n<p><strong>P\u0113tnieki p\u0101rskat\u012bja 161 rakstu.<\/strong><\/p>\n\n\n\n<p>P\u0101rbaudiet <a href=\"https:\/\/jvat.biomedcentral.com\/articles\/10.1186\/s40409-018-0178-3\" target=\"_blank\" rel=\"noreferrer noopener\">ori\u0123in\u0101lais raksts \u0161eit<\/a>.<\/p>\n\n\n\n<h2><strong>Grafiskie kopsavilkumi, ko nodro\u0161ina Mind the Graph<\/strong><\/h2>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html.webp\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"1003\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-1024x1003.webp\" alt=\"\" class=\"wp-image-20251\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-1024x1003.webp 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-300x294.webp 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-768x752.webp 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-12x12.webp 12w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-100x98.webp 100w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html.webp 1418w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>Izgatavots ar <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Autors izmantoja Mind the Graph platformu, lai izveidotu shematisku att\u0113lu par asinsrites, audu un \u0161\u016bnu notikumiem, ko modul\u0113 krotoks\u012bns un t\u0101 apak\u0161vien\u012bbas iekaisuma stimul\u0113\u0161anas laik\u0101.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_Fig3_HTML.webp\"><img decoding=\"async\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_Fig3_HTML-839x1024.webp\" alt=\"\" class=\"wp-image-20252\"\/><\/a><figcaption class=\"wp-element-caption\"><em>Izgatavots ar <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Autors ar\u012b detaliz\u0113ti aprakst\u012bja asinsriti, limfoc\u012btu nok\u013c\u016b\u0161anu limfmezglos un \u0161\u016bnu notikumus, kas saist\u012bti ar krotoks\u012bna un t\u0101 apak\u0161vien\u012bbu im\u016bnsupres\u012bvo iedarb\u012bbu.<\/p>\n\n\n\n<p><strong>Tas ir infografikas sp\u0113ks!<\/strong><\/p>\n\n\n\n<p>\u0160\u0137iet, ka autoru secin\u0101jumi nostiprina iepriek\u0161\u0113jo darbu \u0161aj\u0101 jom\u0101: \"Krotoks\u012bns sp\u0113ja nom\u0101kt specifisku anti-HSA IgG1 un IgG2a antivielu veido\u0161anos no HAS imuniz\u0113t\u0101m pel\u0113m, nor\u0101dot uz t\u0101 sp\u0113ju modul\u0113t Th1 un Th2 atbildes reakcijas,\" apgalvoja Sartim.<\/p>\n\n\n\n<h2><strong>Dokumenti Ietekme un veiktsp\u0113ja<\/strong><\/h2>\n\n\n\n<p>M\u0113s varam analiz\u0113t ar <a href=\"https:\/\/mindthegraph.com\/blog\/altmetric\/\" target=\"_blank\" rel=\"noreferrer noopener\">Altmetric<\/a> dati, ka \u0161im dokumentam bija vair\u0101k cit\u0101tu <strong>nek\u0101 <strong>84%<\/strong><\/strong> <strong>citi raksti no Springer Nature.<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1.png\"><img decoding=\"async\" loading=\"lazy\" width=\"322\" height=\"578\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1.png\" alt=\"\" class=\"wp-image-20254\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1.png 322w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1-167x300.png 167w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1-7x12.png 7w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1-56x100.png 56w\" sizes=\"(max-width: 322px) 100vw, 322px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>Avots: <a href=\"https:\/\/citations.springernature.com\/item?doi=10.1186\/s40409-018-0178-3&amp;start=11&amp;years=&amp;journals=&amp;books=&amp;authors=\" target=\"_blank\" rel=\"noreferrer noopener\">Crossref<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Izmantojiet infografikas iesp\u0113jas, lai veicin\u0101tu un <a href=\"https:\/\/mindthegraph.com\/blog\/research-journal-impact-factor\/\">ietekm\u0113t j\u016bsu rakstu<\/a> k\u0101 ar\u012b. Izm\u0113\u0123iniet Mind the Graph!<\/p>\n\n\n\n<div class=\"is-layout-flex wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"https:\/\/mindthegraph.com\/app\/auth\/register?from_url=\/\" style=\"border-radius:100px;background-color:#dc1866\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Izm\u0113\u0123iniet Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Var\u0113tu b\u016bt mazliet gr\u016bti izskaidrot krotoks\u012bna pretiekaisuma modul\u0101ciju bez atbilsto\u0161iem att\u0113liem, bet Mind the Graph past\u0101v!<\/p>","protected":false},"author":29,"featured_media":20047,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - 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