{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"Zikas v\u012bruss replic\u0113jas pieaugu\u0161o cilv\u0113ku smadze\u0146u audos un pasliktina sinapses un atmi\u0146u pel\u0113m Paper Review"},"content":{"rendered":"

ZIKV ir b\u012bstams v\u012bruss, kas plosa pasauli. T\u0101p\u0113c \u0161aj\u0101 gad\u012bjum\u0101 autore p\u0113ta t\u0101 replik\u0101ciju pieaugu\u0161a cilv\u0113ka smadzen\u0113s.<\/p>\n\n\n\n

Zikas v\u012bruss (ZIKV) infic\u0113 pieaugu\u0161o smadze\u0146u audus un izraisa atmi\u0146as trauc\u0113jumus pel\u0113m<\/strong><\/h2>\n\n\n\n

Farmaceitisk\u0101s fakult\u0101tes grupa Klaudijas Figueiredo (Claudia Figueiredo, 2019) vad\u012bb\u0101 p\u0113t\u012bja, k\u0101 zikas v\u012bruss replic\u0113jas pieaugu\u0161a cilv\u0113ka smadze\u0146u audos un pasliktina sinapses un atmi\u0146u pel\u0113m. Zikas v\u012bruss ir arbov\u012bruss, kas pieder Flaviviridae dzimtas v\u012brusiem un ir atbild\u012bgs par neseno lielo uzliesmojumu Lat\u012b\u0146amerik\u0101. <\/p>\n\n\n\n

ZIKV ir konstat\u0113ts pieaugu\u0161o pacientu smadzen\u0113s un smadze\u0146u \u0161\u0137idrum\u0101. NS2B im\u016bnreaktivit\u0101te kolokaliz\u0113j\u0101s ar NeuN-im\u016bnreakt\u012bvaj\u0101m \u0161\u016bn\u0101m, bet ne ar GFAP vai F4\/80, nor\u0101dot, ka ZIKV m\u0113r\u0137tiec\u012bgi ietekm\u0113 neironus nobriedu\u0161a cilv\u0113ka audos. Pieaugu\u0161\u0101m im\u016bnkompetent\u0101m pel\u0113m, kas infic\u0113tas ar ZIKV intracerebroventrikul\u0101ru inf\u016bziju, front\u0101laj\u0101 garoz\u0101 un hipokamp\u0101 konstat\u0113ts augsts ZikV RNS l\u012bmenis, un galvenais infic\u0113to \u0161\u016bnu tips ir nobriedu\u0161ie neironi. <\/p>\n\n\n\n

Tiek apstiprin\u0101ts paaugstin\u0101ts TNF-\u03b1 l\u012bmenis smadzen\u0113s, intens\u012bva mikroglioze, pastiprin\u0101ta komplementa sist\u0113mas prote\u012bnu (C1q un C3) ekspresija un hipokampa sinapses boj\u0101jumi.<\/p>\n\n\n\n

P\u0113t\u012bjum\u0101 tika izmantoti 9 vien\u0101di kvadranti.<\/strong><\/p>\n\n\n\n

P\u0101rbaudiet ori\u0123in\u0101lais raksts \u0161eit<\/a>.<\/p>\n\n\n\n

Grafiskie kopsavilkumi, ko nodro\u0161ina Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Izgatavots ar Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Pirmaj\u0101 att\u0113l\u0101 att\u0113lots gad\u012bjums, kad cilv\u0113ka spuras daivas garozas garozas audu fragmenti tika sagriezti 400 \u00b5m \u0161\u0137\u0113l\u012bt\u0113s un tur\u0113ti kult\u016br\u0101 4 dienas pirms inkub\u0101cijas ar ZIKV (107 PFU) vai izsp\u0113les barotni 1 h, kam sekoja izskalo\u0161ana. <\/p>\n\n\n\n

<\/div>\n\n\n
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Izgatavots ar Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Otraj\u0101 att\u0113l\u0101 redzams, ka pieaugu\u0161\u0101m pel\u0113m smadze\u0146u s\u0101nu kambar\u012b ievad\u012bja 105 PFU ZIKV, UV inaktiv\u0113tu ZIKV vai izsp\u0113les barotni.<\/p>\n\n\n\n

Secin\u0101jumi, \u0161\u0137iet, apstiprina to, kas par \u0161o t\u0113mu bija zin\u0101ms jau iepriek\u0161: \"ZIKV ir v\u0113rsts uz atmi\u0146as smadze\u0146u re\u0123ioniem neatkar\u012bgi no t\u0101, vai infic\u0113\u0161an\u0101s ce\u013c\u0161 ir centr\u0101lais vai perif\u0113rais. V\u012bruss ir konstat\u0113ts smadze\u0146u smadze\u0146u \u0161\u0137idrum\u0101 pieaugu\u0161iem pacientiem ar neirolo\u0123isk\u0101m komplik\u0101cij\u0101m,\" apgalvoja Figueiredo.<\/p>\n\n\n\n

Vi\u0146i ierosina n\u0101kotn\u0113 veikt p\u0113t\u012bjumus, kuru m\u0113r\u0137is ir izp\u0113t\u012bt ZIKV infekcijas ilgtermi\u0146a neirode\u0123enerat\u012bvo ietekmi. Identific\u0113jot veidus, k\u0101 nov\u0113rst sign\u0101lu novirzes, kas izraisa smadze\u0146u disfunkciju, var\u0113tu pav\u0113rt ce\u013cu intervences strat\u0113\u0123ij\u0101m, lai aizkav\u0113tu vai nov\u0113rstu smagu neirolo\u0123isku saslim\u0161anu att\u012bst\u012bbu.<\/p>\n\n\n\n

Dokumenti Ietekme un veiktsp\u0113ja<\/strong><\/h2>\n\n\n\n

M\u0113s varam analiz\u0113t ar Altmetric<\/a> dati, ka \u0161\u012b dokumenta tie\u0161saistes uzman\u012bbas r\u0101d\u012bt\u0101js ir augst\u0101ks. nek\u0101 95%<\/strong><\/strong> visiem citiem l\u012bdz\u012bga vecuma izstr\u0101d\u0101jumiem dab\u0101.<\/strong> \u017durn\u0101li.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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Avots: Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Izmantojiet infografikas sp\u0113ku, lai uzlabotu ar\u012b savu rakstu! S\u0101ciet veidot Mind the Graph.<\/p>\n\n\n\n

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Izm\u0113\u0123iniet Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

P\u0113t\u012bjums ir par ZIKV pieaugu\u0161o cilv\u0113ku smadzen\u0113s - b\u012bstamo v\u012brusu, kas posto\u0161i izplat\u0101s vis\u0101 pasaul\u0113. Proces\u0101 izmantotas Mind the Graph ilustr\u0101cijas.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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