{"id":14387,"date":"2021-08-17T17:07:19","date_gmt":"2021-08-17T20:07:19","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=14387"},"modified":"2024-12-05T15:52:16","modified_gmt":"2024-12-05T18:52:16","slug":"what-is-dmt-everything-researchers-know-about-it","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/kas-ir-dmt-visu-zin-par-to-petnieki-zina-par-to\/","title":{"rendered":"Kas ir DMT? Viss, ko par to zina p\u0113tnieki"},"content":{"rendered":"

Kas ir DMT?<\/h2>\n\n\n\n

DMT jeb N, N-dimetiltriptam\u012bns ir dabiska viela, kas atrodas amazones auga lap\u0101s, kura nosaukums ir Psychotria Viridis<\/em>, ko izmanto ajaskas dz\u0113rien\u0101, kas izraisa halucin\u0101cijas un izmai\u0146as uztver\u0113, emocij\u0101s un izzi\u0146\u0101 tiem, kuri to piedz\u012bvo.<\/p>\n\n\n\n

DMT ir klasific\u0113ts k\u0101 psihoakt\u012bva alkalo\u012bda viela, ko 1971. gad\u0101 aizliedza Starptautisk\u0101 konvencija par psihotropaj\u0101m viel\u0101m, un t\u0101 lieto\u0161ana ir at\u013cauta tikai reli\u0123iskaj\u0101 un ritu\u0101laj\u0101 praks\u0113 uzl\u0113juma dz\u0113riena veid\u0101, ko sauc par ayahuasca.<\/p>\n\n\n\n

\""Molekulu"<\/a>
\"Molekulu\" izp\u0113te Mind the Graph galerij\u0101.<\/figcaption><\/figure>\n\n\n\n

Lai gan ayahuasca ir paz\u012bstama jau vair\u0101k nek\u0101 gadsimtu, tikai p\u0113d\u0113jos gados t\u0101 ir piesaist\u012bjusi zin\u0101tnieku uzman\u012bbu, jo t\u0101s (pagaid\u0101m) ieguvumi nav pier\u0101d\u012bti.<\/p>\n\n\n\n

\u0160is dz\u0113riens tiek pasniegts, lai uzlabotu dz\u012bves kvalit\u0101ti un \u0101rst\u0113tu pacientus ar neirolo\u0123iskiem un emocion\u0101liem trauc\u0113jumiem, piem\u0113ram, depresiju, trauksmi un atkar\u012bbu. <\/p>\n\n\n\n

\"Ko<\/a><\/figure>\n\n\n\n

Ko p\u0113tnieki zina par DMT<\/h2>\n\n\n\n

Raksts, ko public\u0113ja Journal of Affective Disorders Zi\u0146ojumi<\/a> analiz\u0113ja datus no Global Ayahuasca Project (GAP) aptaujas, kur\u0101 piedal\u012bj\u0101s 11 912 cilv\u0113ki, kas bija piedz\u012bvoju\u0161i \u0161o dz\u0113rienu. Aptauj\u0101 dal\u012bbnieki, kuri pirms ayahuasca lieto\u0161anas zi\u0146oja par depresiju vai trauksmi, apgalvoja, ka p\u0113c \u0161\u012bs pieredzes vi\u0146i nov\u0113roju\u0161i zin\u0101mu simptomu uzlabo\u0161anos. T\u0101d\u0113j\u0101di uzlabojas vi\u0146u dz\u012bves kvalit\u0101te. <\/p>\n\n\n\n

P\u0113d\u0113jos gados arvien bie\u017e\u0101k tiek sa\u0146emti t\u0101di pacientu zi\u0146ojumi k\u0101 \u0161is, ko apkopojusi GAP. Neskatoties uz to, ka t\u0101s ir labas zi\u0146as, zin\u0101tniekiem un \u0101rstiem ir nepiecie\u0161ami piln\u012bg\u0101ki un detaliz\u0113t\u0101ki fiziolo\u0123iskie p\u0113t\u012bjumi, lai saprastu \u0161o ajahuaskas priek\u0161roc\u012bbu avotu. Augu inf\u016bzijas dz\u0113rien\u0101 ir vair\u0101kas vielas, un katra no t\u0101m cilv\u0113ka organism\u0101 var izrais\u012bt da\u017e\u0101da veida reakciju. <\/p>\n\n\n\n

Viena no \u0161\u012bm viel\u0101m ir DMT. \u0160\u012b ayahuasca viela ir piesaist\u012bjusi p\u0113tnieku uzman\u012bbu t\u0101s ac\u012bmredzam\u0101 neirog\u0113zes potenci\u0101la d\u0113\u013c.   <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Kas ir neirog\u0113ze?<\/h3>\n\n\n\n

Neurogenesis<\/strong> ir defin\u0113ts k\u0101 transform\u0101cijas process nervu cilmes \u0161\u016bnas<\/strong> vai progenitor<\/strong> \u0161\u016bnas jaunos neironos. Tas ietver ar\u012b daudzas da\u017e\u0101das \u0161\u016bnu darb\u012bbas, tostarp \u0161\u016bnu prolifer\u0101ciju, migr\u0101ciju un diferenci\u0101ciju.<\/p>\n\n\n\n

Savuk\u0101rt, nervu cilmes \u0161\u016bnas<\/strong> sp\u0113j pla\u0161i pa\u0161atjaunoties, radot jaunas nervu sist\u0113mas \u0161\u016bnas, piem\u0113ram, neironus vai glijas \u0161\u016bnas. M\u016bsu smadzen\u0113s ir nervu cilmes \u0161\u016bnu ni\u0161a, kas atrodas nervu cilmes \u0161\u016bn\u0101s. subgranul\u0101r\u0101 zona<\/strong> dentate gyrus hipokamp\u0101. <\/p>\n\n\n\n

Hipokamps ir smadze\u0146u da\u013ca, kas atbild par m\u016bsu atmi\u0146u un m\u0101c\u012b\u0161an\u0101s sp\u0113j\u0101m. \u0160is smadze\u0146u re\u0123ions ir da\u013ca no limbisk\u0101s sist\u0113mas, un tam ir svar\u012bga loma \u012bstermi\u0146a atmi\u0146as p\u0101rv\u0113r\u0161an\u0101 ilgtermi\u0146a atmi\u0146\u0101. <\/p>\n\n\n\n

Neirode\u0123enerat\u012bvo slim\u012bbu, piem\u0113ram, Alcheimera slim\u012bbas, gad\u012bjum\u0101 hipokamps ir pirmais re\u0123ions, kas cie\u0161, un tas izraisa atmi\u0146as pasliktin\u0101\u0161anos. <\/p>\n\n\n\n

K\u0101 DMT ietekm\u0113 smadzenes?<\/h3>\n\n\n\n

K\u0101du laiku tika uzskat\u012bts, ka DMT saist\u0101s tikai ar seroton\u012bna receptoriem 5-HT, kas izraisa halucin\u0101cijas efektu. Tom\u0113r jaun\u0101kie p\u0113t\u012bjumi liecina, ka DMT saist\u0101s ar\u012b ar cita tipa receptoriem - neseroton\u012bner\u0123iskiem receptoriem, ko sauc par seroton\u012bner\u0123iskiem receptoriem. sigma-1 receptoru<\/strong> vai S1R<\/strong>. <\/p>\n\n\n\n

\u0160is receptors ir pla\u0161i izplat\u012bts centr\u0101laj\u0101 nervu sist\u0113m\u0101, \u012bpa\u0161i prefront\u0101laj\u0101 garoz\u0101 un hipokamp\u0101. <\/p>\n\n\n\n

Turkl\u0101t p\u0113tnieki atkl\u0101ja, ka, saistoties ar \u0161o receptoru S1R, DMT zaud\u0113 savu psihoakt\u012bvo iedarb\u012bbu, neradot halucin\u0101cijas vai uztveres izmai\u0146as. <\/p>\n\n\n\n

P\u0113t\u012bjumi in vitro un in vivo<\/h3>\n\n\n\n

P\u0113t\u012bjum\u0101, kas public\u0113ts Translational Psychiatry Journal<\/a> 2020. gad\u0101 tika p\u0113t\u012bta DMT iedarb\u012bba smadzen\u0113s caur sigma-1 receptoru. <\/p>\n\n\n\n

Izmantojot 5-HT antagonistus, p\u0113tnieki nov\u0113roja, ka DMT stimul\u0113 neirog\u0113zi caur S1R. <\/p>\n\n\n\n

Turkl\u0101t ieg\u016btie dati liecina, ka DMT ne tikai stimul\u0113 nervu cilmes \u0161\u016bnu nobrie\u0161anu, prolifer\u0101ciju un migr\u0101ciju in vitro, bet ar\u012b palielina m\u0101c\u012b\u0161an\u0101s un atmi\u0146as sp\u0113jas in vivo. <\/p>\n\n\n\n

P\u0113t\u012bjuma autori zi\u0146oja, ka in vitro DMT veicin\u0101ja neironu progenitoru \u0161\u016bnu prolifer\u0101ciju no hipokampa pieaugu\u0161o neirog\u0113n\u0101s ni\u0161as. \u0160\u012b darb\u012bba palielin\u0101ja \u0161\u016bnu skaitu un lielumu. neirosf\u0113ras<\/strong> p\u0113c ned\u0113\u013cas \u0101rst\u0113\u0161anas ar DMT. <\/p>\n\n\n\n

Turkl\u0101t, pamatojoties uz specifisku olbaltumvielu ekspresiju, p\u0113tnieki ar\u012b nov\u0113roja, ka DMT veicina \u0161o nervu cilmes \u0161\u016bnu diferenci\u0101ciju. <\/p>\n\n\n\n

Ar DMT apstr\u0101d\u0101taj\u0101s neirosf\u0113r\u0101s palielin\u0101j\u0101s olbaltumvielu, kas sastopamas tikai jaunos un nobriedu\u0161os neironos, \u03b2-III-tubul\u012bna un MAP-2, ekspresija. Tas noz\u012bm\u0113, ka DMT veicina diferenci\u0101ciju uz neironu fenotipu. <\/p>\n\n\n\n

P\u0113tnieki paman\u012bja ar\u012b citu \u0161\u016bnu fenotipu, piem\u0113ram, astroc\u012btu un oligodendroc\u012btu, veicin\u0101\u0161anu, izmantojot S1R.<\/p>\n\n\n\n

In vivo DMT, \u0161\u0137iet, aktiviz\u0113ja subgranul\u0101r\u0101s zonas ni\u0161u caur S1R. <\/p>\n\n\n\n

Pieaugu\u0161\u0101m pel\u0113m, kuras \u0101rst\u0113ja ar DMT, bija \"pastiprin\u0101ta nervu prekursoru prolifer\u0101cija un migr\u0101cija subgranul\u0101raj\u0101 zon\u0101\", teikts rakst\u0101. \u0160is rezult\u0101ts liecina, ka DMT model\u0113jo\u0161i ietekm\u0113 hipokampa neirog\u0113zi, palielinot jaunu neironu skaitu. <\/p>\n\n\n\n

Praks\u0113 pieaugu\u0161\u0101m pel\u0113m, kas tika \u0101rst\u0113tas ar DMT, uzved\u012bbas uzdevumos bija lab\u0101ki rezult\u0101ti nek\u0101 t\u0101m, kas to nedar\u012bja. \u0100rst\u0113taj\u0101 grup\u0101 tika nov\u0113roti uzlabojumi m\u0101c\u012b\u0161an\u0101s un atmi\u0146as uzdevumos. <\/p>\n\n\n\n

\"DMT<\/a><\/figure>\n\n\n\n

Secin\u0101jums<\/h2>\n\n\n\n

Visi \u0161ie rezult\u0101ti ir lieliskas zi\u0146as medic\u012bnas sabiedr\u012bbai. <\/p>\n\n\n\n

Tas liecina, ka ar DMT ir iesp\u0113jams ne tikai stimul\u0113t neirog\u0113zi, bet ar\u012b sasniegt \u0161os rezult\u0101tus bez halucinog\u0113na efekta, izmantojot specifisku receptoru. <\/p>\n\n\n\n

\"\u0160\u012b sp\u0113ja modul\u0113t smadze\u0146u plastiskumu liecina, ka tai ir liels terapeitiskais potenci\u0101ls da\u017e\u0101du psihisku un neirolo\u0123isku trauc\u0113jumu, tostarp neirode\u0123enerat\u012bvo slim\u012bbu, \u0101rst\u0113\u0161an\u0101,\" sac\u012bja Hos\u0113 Anhels Moraless (Jos\u00e9 \u00c1ngel Morales). pazi\u0146ojums<\/a>, viens no raksta autoriem. <\/p>\n\n\n\n

\u0160ie rezult\u0101ti var b\u016btiski ietekm\u0113t turpm\u0101kos p\u0113t\u012bjumus, kas saist\u012bti ar ajahuasku un DMT. Izpratne par to, k\u0101 kontrol\u0113t un ietekm\u0113t neirog\u0113zes procesu, var\u0113tu piln\u012bb\u0101 main\u012bt neirode\u0123ener\u0101cijas slim\u012bbu \u0101rst\u0113\u0161anas veidu.<\/p>\n\n\n\n

Tom\u0113r ir liels piepras\u012bjums p\u0113c p\u0113t\u012bjumiem, lai zin\u0101tnieki piln\u012bb\u0101 izprastu t\u0101du vielu k\u0101 DMT un daudzsolo\u0161u receptoru, piem\u0113ram, sigma-1 receptora, lomu neirog\u0113n\u0113z\u0113. <\/p>\n\n\n\n

L\u012bdz ar pozit\u012bvu perspekt\u012bvu tas var\u0113tu pal\u012bdz\u0113t ne tikai rast jaunus neirode\u0123enerat\u012bvo slim\u012bbu \u0101rst\u0113\u0161anas veidus, bet ar\u012b iz\u0101rst\u0113t \u0161\u012bs slim\u012bbas. <\/p>\n\n\n\n

__________________________<\/p>\n\n\n\n

Vai jums patika infografikas, kas izveidotas, izmantojot zin\u0101tniskaj\u0101 rakst\u0101 sniegtos rezult\u0101tus?<\/p>\n\n\n\n

\u0160\u012bs infografikas tika veidotas, izmantojot gatavas veidnes, kas pieejamas Mind the Graph<\/a>, \u0161is viens<\/a> un \u0161is cits<\/a>. Es izdar\u012bju da\u017eas izmai\u0146as, un \u012bs\u0101 laik\u0101 tas bija gatavs!<\/p>\n\n\n\n

To pa\u0161u varat dar\u012bt ar\u012b ar savu p\u0113tniecisko darbu, jums nav j\u0101s\u0101k no nulles. P\u0101rbaudiet visas veidnes<\/a> pieejams Mind the Graph<\/a>. <\/p>\n\n\n\n

Un s\u0101ciet darbu pie infografikas tie\u0161i tagad<\/a>! <\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

Kas ir DMT? DMT jeb N, N-dimetiltriptam\u012bns ir dabiska viela, kas atrodas amazones auga Psychotria Viridis lap\u0101s, ko izmanto ajahuaskas dz\u0113rien\u0101, kas izraisa halucin\u0101cijas un uztveres, emociju un izzi\u0146as izmai\u0146as tiem, kuri to piedz\u012bvo. DMT ir klasific\u0113ts k\u0101 psihoakt\u012bva alkalo\u012bda viela, un t\u0101 lieto\u0161ana vis\u0101 pasaul\u0113 ir aizliegta, jo [...]<\/p>","protected":false},"author":18,"featured_media":14389,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[840,841,51,839,554,250,775,838],"yoast_head":"\nWhat is DMT? Everything Researchers Know About It - MTG<\/title>\n<meta name=\"description\" content=\"Known for its psychoactive activity, the DMT is a substance present in the ayahuasca beverage. 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