{"id":13008,"date":"2021-06-21T18:09:00","date_gmt":"2021-06-21T21:09:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=13008"},"modified":"2023-01-05T14:38:06","modified_gmt":"2023-01-05T17:38:06","slug":"napping-time-genetics","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/napping-time-genetics\/","title":{"rendered":"Miega laika \u0123en\u0113tika: K\u0101 miegs var ietekm\u0113t \u0123en\u0113tisk\u0101s vari\u0101cijas"},"content":{"rendered":"

Miega laiks dienas laik\u0101 liel\u0101kajai da\u013cai cilv\u0113ku ir vainas prieks.<\/p>\n\n\n

\n
\"Garf\u012blds<\/a><\/figure><\/div>\n\n\n

Liel\u0101koties tas ir ieradums, kas ieaudzin\u0101ts ikdienas rut\u012bn\u0101. Tas ir \u013coti izplat\u012bts daudz\u0101m sug\u0101m, s\u0101kot no mu\u0161\u0101m un beidzot ar z\u012bd\u012bt\u0101jiem.<\/p>\n\n\n\n

Miega gul\u0113\u0161ana ir saist\u012bta ar\u012b ar modr\u012bbas uzlabo\u0161anu, kas ir b\u016btiski tiem, kuri str\u0101d\u0101 v\u0113lu vakar\u0101 vai kuriem parasti tr\u016bkst miega.<\/p>\n\n\n\n

Tiek uzskat\u012bts, ka tas uzlabo veiktsp\u0113ju, atmi\u0146u un mazina stresu. <\/p>\n\n\n\n

Ta\u010du papildus \u0161\u012bm priek\u0161roc\u012bb\u0101m ilgtermi\u0146a miega sekas var\u0113tu b\u016bt hroniskas, kas ietekm\u0113 indiv\u012bda labsaj\u016btu.<\/p>\n\n\n\n

Lai gan \u0161is ir str\u012bd\u012bgs jaut\u0101jums, un iemesls tam var b\u016bt vair\u0101ki faktori, kas saist\u012bti ar auti\u0146biks\u012bt\u0113m, piem\u0113ram, nepietiekams miega cikls, slikts uzturs vai slikta vesel\u012bba.<\/p>\n\n\n\n

Vai miega laiks dienas laik\u0101 ir j\u016bsu laim\u012bg\u0101 stunda? P\u0113tnieki apgalvo pret\u0113jo. <\/strong><\/p>\n\n\n\n

P\u0113tnieku grupa analiz\u0113ja miega ietekmi, izmantojot \u0123en\u0113tisk\u0101s vari\u0101cijas.<\/p>\n\n\n\n

P\u0113t\u012bjuma m\u0113r\u0137is bija izprast da\u017e\u0101du indiv\u012bdu \u0123en\u0113tisk\u0101s vari\u0101cijas, \u0146emot v\u0113r\u0101 vi\u0146u v\u0113lmes attiec\u012bb\u0101 uz gul\u0113\u0161anas ilgumu un izv\u0113li.<\/p>\n\n\n\n

\u0160obr\u012bd genoma asoci\u0101cijas p\u0113t\u012bjum\u0101 ir atkl\u0101ti aptuveni septi\u0146i \u0123en\u0113tiskie loci, kas atbilst gul\u0113\u0161anas laikam dienas laik\u0101.<\/p>\n\n\n\n

P\u0113tnieki izmantoja Apvienot\u0101s Karalistes Biobankas Eiropas izcelsmes dal\u012bbniekus (n=452 633), no kuriem aptuveni 38,2% dal\u012bbnieku reiz\u0113m snauda, bet 5,3% dal\u012bbnieku vienm\u0113r snauda dienas laik\u0101.<\/p>\n\n\n\n

Tie, kas snaudu\u0161i, gandr\u012bz vienm\u0113r biju\u0161i vec\u0101ki v\u012brie\u0161i ar augstu \u0136MI jeb \u0137erme\u0146a masas indeksu, kuriem diagnostic\u0113ti miega trauc\u0113jumi, sm\u0113\u0137\u0113t\u0101ji vai pension\u0101ri. Vi\u0146i veica genoma asoci\u0101cijas p\u0113t\u012bjumu (GWAS) ar augstas kvalit\u0101tes attiecin\u0101miem \u0123en\u0113tiskajiem variantiem, aptverot aptuveni \u010detrus lakus dal\u012bbnieku. Tas tika veikts, mainot da\u017e\u0101dus iepriek\u0161 konstat\u0113tos faktorus.<\/p>\n\n\n\n

Vi\u0146i veiksm\u012bgi identific\u0113ja 123 \u0123en\u0113tiskos lokus kop\u0101 ar viena nukleot\u012bda polimorfismu balst\u012btu iedzimt\u012bbu, kas bija aptuveni 11,9%.<\/p>\n\n\n\n

Vi\u0146i sa\u0161aurin\u0101ja savu GWAS ar person\u0101m ar augst\u0101ku \u0136MI. <\/p>\n\n\n\n

Tika konstat\u0113ts, ka no 123 lokusiem 110 tika aiztur\u0113ti genoma m\u0113roga noz\u012bm\u012bguma zi\u0146\u0101.<\/p>\n\n\n\n

Vi\u0146i ar\u012b analiz\u0113ja da\u017e\u0101du dzimumu dres\u016bras mode\u013cu at\u0161\u0137ir\u012bbas saist\u012bb\u0101 ar X hromosomu. <\/p>\n\n\n\n

Turkl\u0101t vi\u0146i secin\u0101ja ar\u012b par g\u0113niem, kas bija atbild\u012bgi par aptauko\u0161an\u0101s hipersomnolences ce\u013cu: PNOC (prepronocicept\u012bns), <\/em>un PATJ (drupu \u0161\u016bnu polarit\u0101tes komponents).<\/em><\/p>\n\n\n\n

Turkl\u0101t koloniz\u0113t\u0101 FADS1 (tauksk\u0101bju desatur\u0101zes) g\u0113na ekspresija liecin\u0101ja par lip\u012bdu metabolisma pleiotropo ietekmi uz miega modeli.<\/p>\n\n\n\n

Citas korel\u0101cijas tika nov\u0113rotas saist\u012bb\u0101 ar genoma \u0123en\u0113tisko kop\u0101 ar t\u0101d\u0101m paz\u012bm\u0113m k\u0101 glik\u0113miskais indekss, antropometriskais, k\u0101 ar\u012b kardiometaboliskais, no kur\u0101m daudzas korel\u0101cijas tika samazin\u0101tas p\u0113c \u0136MI uzskaites. <\/p>\n\n\n\n

V\u0113l vair\u0101k par to, ka rezult\u0101ts, ko analiz\u0113ja fenoma m\u0113roga asoci\u0101cija, izmantojot dienas miega genoma m\u0113roga polig\u0113nu, pal\u012bdz\u0113ja korel\u0113\u0161anai ar aptauko\u0161anos, hipertensiju un, kas ir vissvar\u012bg\u0101k, ar\u012b ar noteikt\u0101m kardiometabolisk\u0101m slim\u012bb\u0101m saist\u012bt\u0101m slim\u012bb\u0101m. <\/p>\n\n\n\n

Nobeigum\u0101 var secin\u0101t, ka p\u0113t\u012bjuma rezult\u0101ti ir atkl\u0101ti. Da\u017ek\u0101rt tie\u0161i \u0161\u0101di ieradumi izraisa vair\u0101kus nev\u0113lamus sare\u017e\u0123\u012bjumus m\u016bsu organism\u0101. Ir j\u0101iev\u0113ro vesel\u012bga ikdiena un laba dz\u012bvesveida prakse. <\/p>\n\n\n

\n
\"v\u012brietis<\/a><\/figure><\/div>\n\n\n

Lai uzzin\u0101tu vair\u0101k par vi\u0146u p\u0113t\u012bjumiem, skatiet t\u0101l\u0101k sniegto atsauci.<\/p>\n\n\n\n

Dashti, H.S., Daghlas, I., Lane, J.M. et al.<\/em> Dienas miega \u0123en\u0113tiskie faktori un ietekme uz kardiometabolisko vesel\u012bbu. Nat Commun<\/em> 12, 900 (2021). DOI : https:\/\/doi.org\/10.1038\/s41467-020-20585-3<\/a><\/p>\n\n\n\n

Mind the Graph galerij\u0101 var atrast daudzas ar \u0123en\u0113tiku saist\u012btas ilustr\u0101cijas. Noklik\u0161\u0137iniet uz att\u0113la zem\u0101k, lai apskat\u012btu.<\/p>\n\n\n

\n
\"\"\/<\/a><\/figure><\/div>","protected":false},"excerpt":{"rendered":"

Miega laiks dienas laik\u0101 liel\u0101kajai da\u013cai cilv\u0113ku ir vainas prieks. Liel\u0101koties tas ir ar\u012b ieradums, kas ieaudzin\u0101ts ikdienas rut\u012bn\u0101. Tas ir \u013coti izplat\u012bts daudz\u0101m sug\u0101m, s\u0101kot no mu\u0161\u0101m un beidzot ar z\u012bd\u012bt\u0101jiem. Miega gul\u0113\u0161ana ir saist\u012bta ar\u012b ar modr\u012bbas uzlabo\u0161anu, kas ir b\u016btiska tiem, kuri str\u0101d\u0101 v\u0113lu vakar\u0101, vai tiem, kuri ir [...].<\/p>","protected":false},"author":18,"featured_media":13012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nDid you know that taking that nap can influence genetic - MTG<\/title>\n<meta name=\"description\" content=\"Is napping time your happy hour? 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Researchers analyzed the effects of napping through genetics variation.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/lv\/dremez-genetika\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-21T21:09:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-05T17:38:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/06\/napping-time-genetics-img.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"628\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Bruna Soldera\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Napping Time Genetics: How Taking a Nap Can Influence Genetic Variation\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/06\/napping-time-genetics-twitter.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Bruna Soldera\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Did you know that taking that nap can influence genetic - MTG","description":"Is napping time your happy hour? 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