{"id":12274,"date":"2021-02-10T09:13:00","date_gmt":"2021-02-10T11:13:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12274"},"modified":"2023-01-05T13:46:34","modified_gmt":"2023-01-05T16:46:34","slug":"cannabis-and-body-pain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/marihuana-un-kermena-sapes\/","title":{"rendered":"Ka\u0146epes un \u0137erme\u0146a s\u0101pes"},"content":{"rendered":"

P\u0113d\u0113j\u0101 desmitgad\u0113 daudzos kl\u012bniskajos p\u0113t\u012bjumos tika zi\u0146ots par pozit\u012bviem un daudzsolo\u0161iem rezult\u0101tiem, izmantojot uz ka\u0146ep\u0113m balst\u012btas z\u0101les neirop\u0101tisko s\u0101pju \u0101rst\u0113\u0161anai. <\/p>\n\n\n\n

Ar ka\u0146ep\u0113m ir \u0101rst\u0113tas s\u0101pes, kas saist\u012btas ar diab\u0113tu, \u0137\u012bmijterapiju, multiplo sklerozi, fibromial\u0123iju, osteoartr\u012btu un vair\u0101k\u0101m cit\u0101m slim\u012bb\u0101m. <\/p>\n\n\n\n

Ac\u012bmredzot past\u0101v saikne starp eksog\u0113niem kanabino\u012bdiem un opio\u012bdu receptoriem, k\u0101 rezult\u0101t\u0101 palielin\u0101s pacientu analg\u0113zija - nesp\u0113ja sajust s\u0101pes. <\/p>\n\n\n\n

Pacientiem, kuri tiek \u0101rst\u0113ti ar opio\u012bdiem kop\u0101 ar z\u0101l\u0113m, kuru pamat\u0101 ir ka\u0146epes, nov\u0113ro z\u0101\u013cu siner\u0123isko efektu, kad opio\u012bdu efektivit\u0101ti palielina tetrahidrokanabinols - THC, kas ir galven\u0101 psihoakt\u012bv\u0101 molekula ka\u0146epju aug\u0101. <\/p>\n\n\n\n

Zin\u0101tnieki uz \u0161iem rezult\u0101tiem raug\u0101s pozit\u012bvi, jo past\u0101v iesp\u0113ja samazin\u0101t opio\u012bdu medikamentu devas, t\u0101d\u0113j\u0101di uzlabojot s\u0101pju pacientu dz\u012bves kvalit\u0101ti.<\/p>\n\n\n\n

Endokanabino\u012bdu sist\u0113ma, t\u0101pat k\u0101 citi metabolisma ce\u013ci, nav izol\u0113ta cilv\u0113ka organisma sist\u0113ma, to var ietekm\u0113t un ietekm\u0113t citi sign\u0101lce\u013ci, viens no tiem ac\u012bmredzot ir saist\u012bts ar opio\u012bdiem un to receptoriem. <\/p>\n\n\n\n

Opio\u012bdu receptoriem papildus s\u0101pju saj\u016btas signaliz\u0113\u0161anas funkcijai ir ar\u012b modul\u0101cijas funkcija, piem\u0113ram, termoregul\u0101cija, hormon\u0101l\u0101 stabilit\u0101te, prets\u0101pju darb\u012bba un citas \u0137erme\u0146a funkcijas. <\/p>\n\n\n\n

Gan kanabino\u012bdu, gan opio\u012bdu receptori ir G-prote\u012bna saist\u012bto receptoru grupas locek\u013ci, kas ir olbaltumvielas, kuras sp\u0113j ietekm\u0113t neirotransmisiju, kas atbild par s\u0101pju izplat\u012b\u0161anos galvas un muguras smadzen\u0113s. <\/p>\n\n\n\n

Hronisku s\u0101pju pacientu \u0101rst\u0113\u0161an\u0101 parasti tiek lietotas pak\u0101peniski pieaugo\u0161as opio\u012bdu devas, kas bie\u017ei izraisa nev\u0113lamas blakuspar\u0101d\u012bbas, piem\u0113ram, sed\u0101ciju, elpo\u0161anas trauc\u0113jumus un aizciet\u0113jumus. <\/p>\n\n\n\n

P\u0113c k\u0101da laika pacienti s\u0101k izr\u0101d\u012bt toleranci un rezistenci pret opio\u012bdu devu, nesasniedzot t\u0101s terapeitisko iedarb\u012bbu, liekot \u0101rstiem atk\u0101rtoti palielin\u0101t devu, lai sasniegtu t\u0101du pa\u0161u s\u0101pju remd\u0113\u0161anas l\u012bmeni.<\/p>\n\n\n\n

Liela THC deva vien tiek uzskat\u012bta par prets\u0101pju l\u012bdzekli, ta\u010du parasti tai seko nev\u0113lamas blakuspar\u0101d\u012bbas, piem\u0113ram, trauksme, galvass\u0101pes, sausums mut\u0113, reibonis, eiforija un tahikardija, savuk\u0101rt mazas devas visp\u0101r neizraisa prets\u0101pju efektu. <\/p>\n\n\n\n

Tom\u0113r kombin\u0101cij\u0101 ar opio\u012bdiem \u0161o iedarb\u012bbu var piln\u012bb\u0101 main\u012bt.<\/p>\n\n\n\n

P\u0113t\u012bjumi, kas veikti ar dz\u012bvnieku mode\u013ciem, liecina, ka eksog\u0113nie kanabino\u012bdi, piem\u0113ram, THC, var palielin\u0101t opio\u012bdu, piem\u0113ram, morf\u012bna, efektivit\u0101ti. <\/p>\n\n\n\n

\u0160\u0137iet, ka THC prets\u0101pju darb\u012bbu izraisa opio\u012bdu receptori, savstarp\u0113ji mijiedarbojoties kanabino\u012bdu un opio\u012bdu signaliz\u0101cijas ce\u013ciem. <\/p>\n\n\n\n

Ka\u0146epju p\u0113tnieki zi\u0146o, ka THC lieto\u0161ana var stimul\u0113t endog\u0113no opio\u012bdu pept\u012bdu veido\u0161anos organism\u0101, kas galu gal\u0101 saist\u0101s ar jau zin\u0101majiem opio\u012bdu receptoriem - delta un kappa - un t\u0101d\u0113j\u0101di starpnieko kanabino\u012bdu iedarb\u012bbu. <\/p>\n\n\n\n

Morf\u012bna ievad\u012b\u0161anas laik\u0101 aktiviz\u0113jas ar\u012b tre\u0161ais opio\u012bdu receptoru mu. \u0160o tr\u012bs opio\u012bdu receptoru aktiviz\u0101cija var b\u016bt izskaidrojums antinocicept\u012bv\u0101 afekta - analg\u0113zijas procesa, kas blo\u0137\u0113 s\u0101p\u012bga stimula atkl\u0101\u0161anu, - efektivit\u0101tes palielin\u0101jumam, sal\u012bdzinot ar morf\u012bna vai THC vien \u0101rst\u0113\u0161anas rezult\u0101tiem.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

A 2004. gad\u0101 Life Sciences \u017eurn\u0101l\u0101 public\u0113tais p\u0113t\u012bjums<\/a> apstiprin\u0101ja saikni starp THC un morfiju, inhib\u0113jot opio\u012bdu receptorus ar specifisk\u0101m molekul\u0101m. <\/p>\n\n\n\n

Blo\u0137\u0113jo\u0161o molekulu kl\u0101tb\u016btne izrais\u012bja morf\u012bna efektivit\u0101tes samazin\u0101\u0161anos, sec\u012bgi samazinot t\u0101 terapeitisko iedarb\u012bbu. <\/p>\n\n\n\n

\u0160is rezult\u0101ts apstiprina, cik svar\u012bga ir \u0161o receptoru pieejam\u012bba un to aktiviz\u0113\u0161ana morf\u012bna - un THC - \u0101rst\u0113\u0161anas efektivit\u0101tei. Cit\u0101 eksperiment\u0101, kas tika veikts ar naloksonu - opio\u012bdu antagonistu -, tika blo\u0137\u0113ta THC aktivit\u0101te da\u017e\u0101dos smadze\u0146u re\u0123ionos, piem\u0113ram, ventr\u0101l\u0101s tegment\u0101l\u0101s zonas, hipotal\u0101ma un periakvedukt\u0101l\u0101 pel\u0113k\u0101 (PAG), kas liecina, ka \u0161ie re\u0123ioni ir svar\u012bgi opio\u012bdu un kanabino\u012bdu mijiedarb\u012bbai. <\/p>\n\n\n\n

Turkl\u0101t p\u0113t\u012bjum\u0101 ar\u012b zi\u0146ots, ka pe\u013cu \u0101rst\u0113\u0161ana ar maz\u0101m THC un morfija dev\u0101m kop\u0101 neizrais\u012bja opio\u012bdu toleranci.<\/p>\n\n\n\n

\u0160is un daudzi citi p\u0113t\u012bjumi ir public\u0113ti, lai apstiprin\u0101tu ideju, ka kanabino\u012bdi kombin\u0101cij\u0101 var palielin\u0101t opio\u012bdu iedarb\u012bbu. <\/p>\n\n\n\n

Kanabino\u012bdi ac\u012bmredzot var main\u012bt ar\u012b opio\u012bdu panesam\u012bbu un atkar\u012bbu no tiem. <\/p>\n\n\n\n

Ilgsto\u0161a opio\u012bdu lieto\u0161ana parasti ir saist\u012bta ar pacientu atkar\u012bbu, kas noved pie \u013caunpr\u0101t\u012bgas lieto\u0161anas vielas, kurai s\u0101kotn\u0113ji bija tikai terapeitisks m\u0113r\u0137is. <\/p>\n\n\n\n

T\u0101p\u0113c kanabino\u012bdu un opio\u012bdu - piem\u0113ram, THC un morfija - kombin\u0101cija var\u0113tu k\u013c\u016bt par jaunu kombin\u0113t\u0101s terapijas analg\u0113tisko strat\u0113\u0123iju, kas \u013cautu \u0101rstiem samazin\u0101t pacientu liel\u0101s opio\u012bdu devas, k\u0101 ar\u012b mazin\u0101t pacientu \u013caunpr\u0101t\u012bgas lieto\u0161anas un atkar\u012bbas l\u012bmeni no opio\u012bdiem. <\/p>\n\n\n\n

Papildus teorijai, ka kanabino\u012bdi stimul\u0113 endog\u0113nos opio\u012bdus, joproj\u0101m nav skaidrs detaliz\u0113ts kanabino\u012bdu un opio\u012bdu mijiedarb\u012bbas sist\u0113mas meh\u0101nisms. <\/p>\n\n\n\n

Hipot\u0113ze, kas m\u0113\u0123ina izskaidrot iesp\u0113jamo darb\u012bbas meh\u0101nismu, ir t\u0101da, ka kanabino\u012bdi, iesp\u0113jams, veicina opio\u012bdu pept\u012bdu sint\u0113zi vai atbr\u012bvo\u0161anos, palielinot aktiviz\u0113to opio\u012bdu receptoru skaitu, k\u0101 rezult\u0101t\u0101 rodas prets\u0101pju l\u012bmenis. <\/p>\n\n\n\n

Nav skaidrs un zin\u0101ms, kuri pept\u012bdi ir iesaist\u012bti \u0161aj\u0101 proces\u0101, t\u0101p\u0113c zin\u0101tniekiem b\u016btu \u013coti svar\u012bgi piln\u012bb\u0101 izprast \u0161o molekulu strukt\u016bru un to, k\u0101 kanabino\u012bdus var izmantot, lai rad\u012btu prets\u0101pju iedarb\u012bbu, k\u0101 ar\u012b pal\u012bdz\u0113t opio\u012bdu atkar\u012bbas gad\u012bjum\u0101. <\/p>\n\n\n\n

Tom\u0113r kanabino\u012bdi kopum\u0101 ir uzr\u0101d\u012bju\u0161i p\u0101rsteidzo\u0161us rezult\u0101tus, nep\u0101rtraukti iekarojot vietu medic\u012bnas profesion\u0101\u013cu vid\u016b un pier\u0101dot savu potenci\u0101lu k\u0101 alternat\u012bvs medikaments. <\/p>\n\n\n\n

Lai p\u0113tnieki var\u0113tu piln\u012bb\u0101 izprast uz ka\u0146ep\u0113m balst\u012btu z\u0101\u013cu re\u0101lo labumu un iesp\u0113jas cilv\u0113ka organismam un to, k\u0101 vislab\u0101k izmantot ka\u0146epju augu k\u0101 \u0101rstniec\u012bbas l\u012bdzekli, ir j\u0101veic v\u0113l vair\u0101ki p\u0113t\u012bjumi.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Vai jums patika \u0161aj\u0101 rakst\u0101 iek\u013caut\u0101 infografika? Visi ikonas<\/a> \u0160aj\u0101 rakst\u0101 izmantotie un daudzi citi ir pieejami Mind the Graph. Pieejam\u0101s ilustr\u0101cijas varat apskat\u012bt m\u016bsu galerija<\/a>.<\/p>\n\n\n\n

Turkl\u0101t jums nav j\u0101s\u0101k veidot infografikas no nulles - m\u0113s saviem lietot\u0101jiem pied\u0101v\u0101jam redi\u0123\u0113jamas infografiku veidnes, t\u0101p\u0113c vi\u0146iem nav j\u0101s\u0101k no tuk\u0161a audekla. \u0160eit varat apskat\u012bt infografikas veidnes.<\/a><\/p>\n\n\n\n

Varat abon\u0113t ar\u012b vec\u0101ka gadag\u0101juma abonementu un izveidot neierobe\u017eotu skaitu fig\u016bru, noklik\u0161\u0137iniet \u0161eit, lai s\u0101ktu<\/a>!<\/p>\n\n\n\n

Atsauces <\/strong><\/p>\n\n\n\n

BROWN, J. D.; WINTERSTEIN, A. G. Potenci\u0101li nev\u0113lami z\u0101\u013cu blakuspar\u0101d\u012bbas un z\u0101\u013cu mijiedarb\u012bba, lietojot kanabidiolu (CBD) medic\u012bn\u0101 un pat\u0113r\u0113t\u0101jiem. Journal of Clinical Medicine, v. 8, n. 7, 2019. gada 8. j\u016blijs.<\/p>\n\n\n\n

CICHEWICZ, D. L. Kanabino\u012bdu un opio\u012bdu analg\u0113ti\u0137u siner\u0123isk\u0101 mijiedarb\u012bba. Life Sciences, v. 74, n. 11, p. 1317-1324, 30 jan. 2004.<\/p>\n\n\n\n

HANEY, M.; BISAGA, A.; FOLTIN, R. W. Naltreksona un peror\u0101l\u0101 THC mijiedarb\u012bba smagu marihu\u0101nas sm\u0113\u0137\u0113t\u0101ju vid\u016b. Psychopharmacology, v. 166, n. 1, p. 77-85, 1 fev. 2003.<\/p>\n\n\n\n

KUHLEN, M. et al. Efekt\u012bva spasticit\u0101tes \u0101rst\u0113\u0161ana, izmantojot dronabinolu b\u0113rnu paliat\u012bvaj\u0101 apr\u016bp\u0113. European Journal of Pediatric Neurology, t. 20, n. 6, p. 898-903, 2016. gada 1. novembris.<\/p>\n\n\n\n

L\u00d6TSCH, J. et al. Z\u0101\u013cu mijiedarb\u012bba ar pacienta kontrol\u0113tu analg\u0113ziju. Clinical Pharmacokinetics, t. 41, n. 1, p. 31-57, 2002. gada 1. janv\u0101ris.<\/p>\n\n\n\n

LYNCH, M. E.; CLARK, A. J. Cannabis Reduces Opioid Dose in the Treatment of Chronic Non-Cancer Pain. Journal of Pain and Symptom Management, t. 25, n. 6, p. 496-498, 2003. gada 1. j\u016bnijs.<\/p>\n\n\n\n

MANZANARES, J. et al. Opio\u012bdu un kanabino\u012bdu farmakolo\u0123isk\u0101 un bio\u0137\u012bmisk\u0101 mijiedarb\u012bba. Trends in Pharmacological Sciences, v. 20, n. 7, p. 287-294, 1.j\u016bl. 1999.<\/p>\n\n\n\n

WAKLEY, A. A.; CRAFT, R. M. THC-metadona un THC-naltreksona mijiedarb\u012bba attiec\u012bb\u0101 uz \u017eurku diskrimin\u0101ciju, antinocicepciju un lokomociju. Behavioural Pharmacology, t. 22, n. 5 un 6, p. 489-497, komplekts. 2011.<\/p>\n\n\n\n

WELCH, S. P. Kanabino\u012bdu un opio\u012bdu sist\u0113mu mijiedarb\u012bba nocicepcijas modul\u0101cij\u0101. International Review of Psychiatry, t. 21, n. 2, p. 143-151, 2009. gada 1. janv\u0101ris.<\/p>","protected":false},"excerpt":{"rendered":"

P\u0113d\u0113j\u0101 desmitgad\u0113 daudzos kl\u012bniskajos p\u0113t\u012bjumos tika zi\u0146ots par pozit\u012bviem un daudzsolo\u0161iem rezult\u0101tiem, izmantojot uz ka\u0146ep\u0113m balst\u012btas z\u0101les neirop\u0101tisko s\u0101pju \u0101rst\u0113\u0161anai. Ar ka\u0146ep\u0113m ir \u0101rst\u0113tas s\u0101pes, kas saist\u012btas ar diab\u0113tu, \u0137\u012bmijterapiju, multiplo sklerozi, fibromial\u0123iju, osteoartr\u012btu un vair\u0101k\u0101m cit\u0101m slim\u012bb\u0101m. Ac\u012bmredzot past\u0101v saikne starp eksog\u0113niem kanabino\u012bdiem un opio\u012bdu receptoriem, k\u0101 rezult\u0101t\u0101 rodas [...]<\/p>","protected":false},"author":4,"featured_media":12276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[819,51,554],"yoast_head":"\nCannabis and Body Pain - MTG<\/title>\n<meta name=\"description\" content=\"Do you want to know cannabis can impact the body pain? 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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