{"id":12192,"date":"2021-01-27T10:46:16","date_gmt":"2021-01-27T12:46:16","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12192"},"modified":"2023-01-05T14:40:18","modified_gmt":"2023-01-05T17:40:18","slug":"cannabis-and-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/marihuana-un-alcheimera-slimiba\/","title":{"rendered":"Kas ir zin\u0101ms par marihu\u0101nu un Alcheimera slim\u012bbu"},"content":{"rendered":"
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Alcheimera slim\u012bba (Alcheimera slim\u012bba) ir neirode\u0123enerat\u012bva slim\u012bba, kas ir atbild\u012bga par vair\u0101k nek\u0101 50% pa\u0161laik diagnostic\u0113to demences gad\u012bjumu, un t\u0101 ir tie\u0161i saist\u012bta ar noveco\u0161anu. M\u016bsdien\u0101s 40% cilv\u0113ku, kas vec\u0101ki par 85 gadiem, ir saslimu\u0161i ar k\u0101du demences l\u012bmeni.<\/p>\n\n\n\n

Agr\u0101k tika uzskat\u012bts, ka AD simptomi ir saist\u012bti tikai ar izzi\u0146as funkciju pasliktin\u0101\u0161anos, kas ietekm\u0113 \u012bstermi\u0146a atmi\u0146as, bet progres\u0113jo\u0161\u0101 slim\u012bbas stadij\u0101 - ar pacienta valodas sp\u0113ju un pat ilgtermi\u0146a atmi\u0146as pasliktin\u0101\u0161anos.<\/p>\n\n\n\n

Tom\u0113r m\u016bsdien\u0101s ir zin\u0101ms, ka pacientiem, kas cie\u0161 no AD, ir ar\u012b vair\u0101ki citi simptomi, piem\u0113ram, depresija, psihoze, agres\u012bva uzved\u012bba, kas v\u0113l vair\u0101k pasliktina slim\u012bbas gaitu. <\/p>\n\n\n\n

P\u0113d\u0113jos gados p\u0113tnieki un \u0101rsti savos p\u0113t\u012bjumos ir zi\u0146oju\u0161i par pozit\u012bviem rezult\u0101tiem, s\u0101kot \u0101rst\u0113t savus pacientus ar AD, izmantojot z\u0101les uz ka\u0146epju b\u0101zes un pan\u0101kot simptomu mazin\u0101\u0161anos.<\/p>\n\n\n\n

Endokanabino\u012bdu sist\u0113ma ir k\u013cuvusi par alternat\u012bvu pieeju da\u017e\u0101du slim\u012bbu un patolo\u0123iju \u0101rst\u0113\u0161anai, papildus t\u0101s ietekmei uz vair\u0101kiem procesiem, piem\u0113ram, neiroplasticit\u0101ti, neiroinflam\u0101ciju, uzved\u012bbas trauc\u0113jumiem, miega regul\u0101ciju, imunolo\u0123iskaj\u0101m funkcij\u0101m, iekaisuma slim\u012bb\u0101m, sirds un asinsvadu funkcij\u0101m, s\u0101p\u0113m, kust\u012bbu kontroli, ener\u0123ijas l\u012bdzsvaru un apet\u012bti. <\/p>\n\n\n\n

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Foto: Ravi Patel<\/a> vietn\u0113 Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Diem\u017e\u0113l joproj\u0101m ir maz ofici\u0101lu p\u0113t\u012bjumu, kuros tie\u0161i analiz\u0113ta saist\u012bba starp endokanabino\u012bdu sist\u0113mu un Alcheimera slim\u012bbu.<\/p>\n\n\n\n

M\u016bsdien\u0101s ir labi zin\u0101ms, ka Alcheimera slim\u012bbu izraisa \u0123en\u0113tiski un noveco\u0161an\u0101s faktori. Galvenie \u0161\u012bs slim\u012bbas vaininieki tiek attiecin\u0101ti uz senila pl\u0101ksn\u012btes<\/strong> un neirofibrilo pl\u016bsto\u0161s<\/strong>. <\/p>\n\n\n\n

Interesants fakts ir tas, ka, izmantojot AD \u017eurku mode\u013cus, p\u0113tnieki atkl\u0101ja, ka AD smadzen\u0113s ir maz\u0101ks CB1 receptoru skaits sal\u012bdzin\u0101jum\u0101 ar vesel\u0101m smadzen\u0113m - maz\u0101ks CB1 receptoru skaits var samazin\u0101t z\u0101\u013cu terapeitisko iedarb\u012bbu.<\/p>\n\n\n\n

\u0100rst\u0113\u0161ana ar kanabino\u012bdiem var rad\u012bt aizsarg\u0101jo\u0161u iedarb\u012bbu pret oksidat\u012bvo stresu un neiroiekaisumu Alcheimera slim\u012bbas pacientu smadzen\u0113s, pal\u012bdzot samazin\u0101t amilo\u012bda pl\u0101ksn\u012b\u0161u un neirofibril\u0101ro plankumu veido\u0161anos, t\u0101d\u0113j\u0101di pal\u0113ninot pacientu kognit\u012bvo sp\u0113ju pasliktin\u0101\u0161anos. <\/p>\n\n\n\n

Lai gan amilo\u012bda pl\u0101ksn\u012btes var atrast ar\u012b vesel\u0101s smadzen\u0113s, to bie\u017eums ir \u0101rk\u0101rt\u012bgi zem\u0101ks sal\u012bdzin\u0101jum\u0101 ar ADE smadzen\u0113m.<\/p>\n\n\n\n

P\u0113t\u012bjumos, kas velt\u012bti tam, lai saprastu, k\u0101p\u0113c kanabino\u012bdiem ir terapeitiska iedarb\u012bba uz pacientiem ar AD, atkl\u0101ts, ka THC molekula sp\u0113j palielin\u0101t neiromediatora, ko sauc par neirotransmiteru, biopieejam\u012bbu. acetilhol\u012bns<\/strong> (Ach), inhib\u0113jot t\u0101 no\u0101rd\u012b\u0161anas fermentu acetilhol\u012bnester\u0101ze<\/strong> (AChE) - Ach b\u016bt\u012bb\u0101 ir atbild\u012bgs par nervu impulsa p\u0101rraidi uz n\u0101kamo neironu. <\/p>\n\n\n\n

Enz\u012bma AChE uzdevums vesel\u0101s smadzen\u0113s ir no\u0101rd\u012bt Ach, tom\u0113r smadzen\u0113s ar Alcheimera slim\u012bbu \u0161is enz\u012bms ir \u013coti izteikts, no\u0101rdot daudz vair\u0101k Ach, nek\u0101 tam vajadz\u0113tu, un laika gait\u0101 izraisa smadze\u0146u izzi\u0146as funkciju pasliktin\u0101\u0161anos.   <\/p>\n\n\n\n

P\u0113tnieki zi\u0146oja, ka kanabino\u012bdi var pal\u012bdz\u0113t, jo tie inhib\u0113 fermentu AChE - ir pier\u0101d\u012bta lab\u0101ka reakcija nek\u0101 citas komerci\u0101li pieejamas z\u0101les. <\/p>\n\n\n\n

THC var ar\u012b pal\u012bdz\u0113t mazin\u0101t uzved\u012bbas trauc\u0113jumus un regul\u0113 pacientu ar smagu demenci diennakts ciklu. Da\u017ei zin\u0101tnieki pat apstiprina, ka THC un CBD kanabino\u012bdiem ir potenci\u0101ls b\u016bt pret Alcheimera slim\u012bbu.<\/p>\n\n\n\n

2015. gad\u0101 \u017eurn\u0101l\u0101 Clinical Pharmacology and Therapeutics public\u0113taj\u0101 rakst\u0101<\/a>, sniedz p\u0101rskatu par kanabino\u012bdu potenci\u0101lu v\u0113l\u012bn\u0101 Alcheimera slim\u012bbas un ar to saist\u012bto neiropsihiatrisko simptomu \u0101rst\u0113\u0161an\u0101 gados vec\u0101kiem cilv\u0113kiem, apl\u016bkojot ar\u012b uz ka\u0146ep\u0113m balst\u012btu z\u0101\u013cu efektivit\u0101tes, dro\u0161\u012bbas un farmakokin\u0113tikas aspektus.<\/p>\n\n\n\n

72 gadus vecam v\u012brietim ar Alcheimera slim\u012bbu bija uzved\u012bbas trauc\u0113jumi, piem\u0113ram, uzbudin\u0101jums un agresivit\u0101te. Vi\u0146a iepriek\u0161\u0113j\u0101 \u0101rst\u0113\u0161ana neuzr\u0101d\u012bja b\u016btisku uzlabojumu. <\/p>\n\n\n\n

Kad pacientam tika ievad\u012bts Nabilons - sint\u0113tisks THC medikaments -, vi\u0146am dr\u012bz vien uzlaboj\u0101s uzved\u012bbas trauc\u0113jumi un citi simptomi, turkl\u0101t \u0101rst\u0113\u0161anas laik\u0101 ar THC b\u0101zes medikamentu vi\u0146am nebija nek\u0101du blakuspar\u0101d\u012bbu.<\/p>\n\n\n\n

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Foto: Louis Reed<\/a> vietn\u0113 Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Cit\u0101 p\u0113t\u012bjuma grup\u0101, kur\u0101 bija piecpadsmit pacienti ar Alcheimera slim\u012bbu - vid\u0113jais vecums 72 gadi -, pirms \u0101rst\u0113\u0161anas tika konstat\u0113ti uzved\u012bbas trauc\u0113jumi un \u0113\u0161anas probl\u0113mas. <\/p>\n\n\n\n

Piecpadsmit pacienti se\u0161as ned\u0113\u013cas tika \u0101rst\u0113ti ar dronabinola - paz\u012bstama ar\u012b k\u0101 marinols - sint\u0113tisku THC narkotiku. <\/p>\n\n\n\n

P\u0113c \u0101rst\u0113\u0161anas perioda vi\u0146i nov\u0113roja uzved\u012bbas uzlabo\u0161anos, svara pieaugumu un uzbudin\u0101juma samazin\u0101\u0161anos, sal\u012bdzinot ar placebo. Tika nov\u0113rotas da\u017eas nev\u0113lamas blakuspar\u0101d\u012bbas, piem\u0113ram, nogurums, miegain\u012bba un eiforija, kas visas ir apstiprin\u0101ju\u0161as, ka ir saist\u012btas ar dronabinola lieto\u0161anu.<\/p>\n\n\n\n

Cita se\u0161u pacientu grupa, kuru vid\u0113jais vecums bija 81 gads, da\u017ei no vi\u0146iem bija ar Alcheimera slim\u012bbu, bet citi cieta no smagas demences, s\u0101ka divu ned\u0113\u013cu \u0101rst\u0113\u0161anu ar dronabinola prepar\u0101tu. <\/p>\n\n\n\n

Rezult\u0101ti liecin\u0101ja par iev\u0113rojamu \u0161o pacientu nakts motorisko aktivit\u0101\u0161u uzlabo\u0161anos un lab\u0101ku uzved\u012bbu. \u0160aj\u0101 grup\u0101 netika nov\u0113rotas nek\u0101das blakuspar\u0101d\u012bbas.<\/p>\n\n\n\n

Cit\u0101 p\u0113t\u012bjum\u0101 piedal\u012bj\u0101s 40 pacienti ar da\u017e\u0101da l\u012bme\u0146a demenci, no kuriem 13 bija ar Alcheimera slim\u012bbu. <\/p>\n\n\n\n

Visiem tika uzs\u0101kta \u0101rst\u0113\u0161ana ar dronabinolu, lai \u0101rst\u0113tu uzved\u012bbas probl\u0113mas un apet\u012btes trauc\u0113jumus. <\/p>\n\n\n\n

\u0100rst\u0113\u0161anas periods bija 17 dienas, un pacientiem uzlaboj\u0101s abos aspektos. Tika zi\u0146ots par t\u0101d\u0101m nev\u0113lam\u0101m blakuspar\u0101d\u012bb\u0101m k\u0101 sed\u0101cija, del\u012brijs, ur\u012bnce\u013cu infekcijas un apjukums, ta\u010du, k\u0101 nor\u0101da p\u0113tnieki, t\u0101s nebija tie\u0161i saist\u012btas ar dronabinola lieto\u0161anu.<\/p>\n\n\n\n

Neskatoties uz vair\u0101kiem p\u0113t\u012bjumiem, kuru rezult\u0101ti liecina par pozit\u012bviem rezult\u0101tiem, izmantojot kanabino\u012bdus demences pacientu \u0101rst\u0113\u0161an\u0101, da\u017ei p\u0113tnieki apgalvo, ka joproj\u0101m nav pietiekami daudz pier\u0101d\u012bjumu, lai pier\u0101d\u012btu, ka kanabino\u012bdi ir patie\u0161\u0101m labi un dro\u0161i uzved\u012bbas trauc\u0113jumu un demences \u0101rst\u0113\u0161an\u0101.<\/p>\n\n\n\n

P\u0113tnieki arvien bie\u017e\u0101k zi\u0146o, ka z\u0101les, kuru pamat\u0101 ir marihu\u0101na, tiek lietotas pacientu ar Alcheimera slim\u012bbu \u0101rst\u0113\u0161an\u0101, un ne tikai, t\u0101s tiek izmantotas ar\u012b Parkinsona slim\u012bbas un autisma \u0101rst\u0113\u0161an\u0101, un \u0101rsti un zin\u0101tnieki zi\u0146o, ka p\u0113c tam, kad pacienti s\u0101ku\u0161i lietot z\u0101les, kuru pamat\u0101 ir marihu\u0101na, vi\u0146u dz\u012bves kvalit\u0101te ir uzlabojusies. Bet tas ir temats n\u0101kamajam rakstam.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Vai esat no neirolo\u0123ijas jomas? Mind the Graph ir liela neirolo\u0123ijas ilustr\u0101ciju kategorija, kur\u0101 j\u016bs varat atrast visu, kas nepiecie\u0161ams j\u016bsu neirolo\u0123ijas refer\u0101tam vai prezent\u0101cijai. P\u0101rbaudiet \u0161eit<\/a>.  <\/strong><\/p>\n\n\n\n

Vai <\/strong>j\u016bs mekl\u0113jat bio\u0137\u012bmija <\/a>un molekul\u0101r\u0101 biolo\u0123ija<\/a> ilustr\u0101cijas var atrast ar\u012b Mind the Graph. <\/p>\n\n\n\n

Un m\u0113s esam gatavi jums pal\u012bdz\u0113t, ja jums ir nepiecie\u0161ams v\u0113l kaut kas cits. pieteikties sav\u0101 kont\u0101<\/a> un nos\u016btiet mums zi\u0146u PIEPRAS\u012aT IKONU<\/strong>. <\/p>\n\n\n\n

Atsauces<\/strong><\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoids in late-onset Alzheimer's disease. Kl\u012bnisk\u0101 farmakolo\u0123ija un terapija<\/strong>, v. 97, n. 6, p. 597-606, 2015. gads.<\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoids in late-onset Alzheimer's disease. Kl\u012bnisk\u0101 farmakolo\u0123ija un terapija<\/strong>, v. 97, n. 6, p. 597-606, 2015. gads.<\/p>\n\n\n\n

BALASH, Y. et al. Medic\u012bnisk\u0101 marihu\u0101na Parkinsona slim\u012bbas gad\u012bjum\u0101: Re\u0101l\u0101 pacientu pieredze. Kl\u012bnisk\u0101 neirofarmakolo\u0123ija<\/strong>, v. 40, n. 6, p. 268-272, dez. 2017.<\/p>\n\n\n\n

BENITO, C. et al. Endokanabino\u012bdu sist\u0113ma un Alcheimera slim\u012bba. Molekul\u0101r\u0101 neirobiolo\u0123ija<\/strong>, t. 36, n. 1, p. 75-81, 1 ago. 2007.<\/p>\n\n\n\n

DE FARIA, S. M. et al. Ak\u016btas kanabidiola lieto\u0161anas ietekme uz trauksmi un tr\u012bci, ko izraisa simul\u0113ts publisk\u0101s runas tests pacientiem ar Parkinsona slim\u012bbu. Journal of Psychopharmacology<\/strong>, t. 34, n. 2, p. 189-196, 2020. gada 1. febru\u0101ris.<\/p>\n\n\n\n

FALCO, A. D. et al. DOEN\u00c7A DE ALZHEIMER: HIP\u00d3TESES ETIOL\u00d3GICAS E PERSPECTIVAS DE TRATAMENTO. Qu\u00edmica Nova<\/strong>, t. 39, n. 1, p. 63-80, 2016. gada janv\u0101ris.<\/p>\n\n\n\n

LEEHEY, M. A. et al. Cannabidiol safety and Tolerability in Parkinson Disease: An Open Label, Dose-Escalation Study. Ka\u0146epju un kanabino\u012bdu p\u0113tniec\u012bba<\/strong>, 19 mar. 2020.<\/p>\n\n\n\n

POLEG, S. et al. Cannabidiol as a suggested candidate for treatment of autism spectrum disorder. Progress neirofizofarmakolo\u0123ij\u0101 un biolo\u0123iskaj\u0101 psihiatrij\u0101<\/strong>, v. 89, p. 90-96, 8 mar. 2019.YOO, K.-Y.; PARK, S.-Y. Terpenoids as Potential Anti-Alzheimer's Disease Therapeutics. Molekulas<\/strong>, v. 17, n. 3, p. 3524-3538, mar. 2012.<\/p>","protected":false},"excerpt":{"rendered":"

Alcheimera slim\u012bba (Alcheimera slim\u012bba) ir neirode\u0123enerat\u012bva slim\u012bba, kas ir atbild\u012bga par vair\u0101k nek\u0101 50% pa\u0161laik diagnostic\u0113to demences gad\u012bjumu, un t\u0101 ir tie\u0161i saist\u012bta ar noveco\u0161anu. M\u016bsdien\u0101s 40% cilv\u0113ku, kas vec\u0101ki par 85 gadiem, ir saslimu\u0161i ar k\u0101du demences l\u012bmeni. Agr\u0101k tika uzskat\u012bts, ka AD simptomi ir saist\u012bti tikai ar izzi\u0146as funkciju pasliktin\u0101\u0161anos, kas ietekm\u0113 \u012bstermi\u0146a atmi\u0146u, bet [...]<\/p>","protected":false},"author":4,"featured_media":12193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959],"tags":[213,819,554],"yoast_head":"\nWhat is Out There About Cannabis and Alzheimer\u2019s Disease - MTG<\/title>\n<meta name=\"description\" content=\"Do you know Cannabis and Alzheimer's Disease can be related? 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