{"id":12175,"date":"2021-01-25T09:30:00","date_gmt":"2021-01-25T11:30:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12175"},"modified":"2023-05-22T11:11:05","modified_gmt":"2023-05-22T14:11:05","slug":"molecular-control-knob-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/molekularas-kontroles-pogas-smadzenem\/","title":{"rendered":"\"Molekul\u0101r\u0101s kontroles poga\" smadzen\u0113s, kas pal\u012bdz m\u0101c\u012bties un atcer\u0113ties"},"content":{"rendered":"

Katrai ma\u0161\u012bnai ir vad\u012bbas panelis da\u017e\u0101du funkciju, jo \u012bpa\u0161i iesl\u0113g\u0161anas un izsl\u0113g\u0161anas meh\u0101nisma, kontrolei. <\/p>\n\n\n\n

Vai k\u0101dreiz esat aizdom\u0101ju\u0161ies, ka ar\u012b m\u016bsu smadzen\u0113m ir t\u0101da funkcija, ar kuru var\u0113tu kontrol\u0113t smadze\u0146u funkcijas? <\/p>\n\n\n\n

Nu, jauni p\u0113t\u012bjumi liecina, ka \"tilpums molekul\u0101ro pogu \", kas regul\u0113 elektrisko sign\u0101lu smadzen\u0113s m\u0101c\u012b\u0161an\u0101s un jo \u012bpa\u0161i ar atmi\u0146u. <\/p>\n\n\n\n

Tas var\u0113tu b\u016bt galvenais sl\u0113d\u017ea meh\u0101nisms, kas var\u0113tu main\u012bt sp\u0113les nervu sist\u0113mas trauc\u0113jumu gad\u012bjum\u0101.<\/p>\n\n\n\n

Maikla Hoppa un vi\u0146a komandas public\u0113taj\u0101 p\u0113t\u012bjum\u0101 nor\u0101d\u012bts, ka liela noz\u012bme var\u0113tu b\u016bt elektrisko sign\u0101lu regul\u0113\u0161anai. P\u0113t\u012bjums bija v\u0113rsts uz sign\u0101lu regul\u0113jo\u0161o molekulu identific\u0113\u0161anu.<\/p>\n\n\n\n

P\u0112T\u012aJUMA KONCEPCIJA<\/p>\n\n\n\n

Sinapses ir savienojumi, kuros notiek elektrisko sign\u0101lu p\u0101rraide starp nervu \u0161\u016bn\u0101m. <\/p>\n\n\n\n

\u0160os elektriskos sign\u0101lus smadzenes p\u0101rv\u0113r\u0161 \u0137\u012bmiskos neiromediatoros, kas ce\u013co pa sinaptisk\u0101m spraug\u0101m. Komanda aprakst\u012bja, k\u0101 elektrisko sign\u0101lu formas labv\u0113l\u012bgi ietekm\u0113 sinapses darb\u012bbu. <\/p>\n\n\n\n

Neironiem, kas tiek aktiviz\u0113ti neirotransmisijas laik\u0101, ir da\u017e\u0101di mode\u013ci. <\/p>\n\n\n\n

\u0160\u012bs formas un skaita izmai\u0146as izraisa sinapses pastiprin\u0101\u0161anos vai pav\u0101jin\u0101\u0161anos (ko d\u0113v\u0113 ar\u012b par sinaptisko plastiskumu ). <\/p>\n\n\n\n

Kad smadze\u0146u \u0161\u016bnas, kas atrodas abos sinapses galos, nep\u0101rtraukti apmain\u0101s ar \u0137\u012bmiskiem sign\u0101liem, notiek ilgsto\u0161a potenc\u0113\u0161ana (LTP). <\/p>\n\n\n\n

\u0160\u012b LTP uzlabo sign\u0101lu apmai\u0146u starp \u0161\u016bn\u0101m un sinaps\u0113m, k\u0101 ar\u012b stiprina sinapses. \u0160\u012b LTP ir pamat\u0101 m\u0101c\u012b\u0161an\u0101s un atmi\u0146u veido\u0161anai smadzen\u0113s viet\u0101, ko sauc par hipokampu.<\/p>\n\n\n\n

P\u0113tnieki koncentr\u0113j\u0101s uz hipokampa zonu smadzen\u0113s. Vi\u0146i atkl\u0101ja, ka \u0161aj\u0101 apgabal\u0101 sinaps\u0113s p\u0101rraid\u012btie sign\u0101li ir analogi. <\/p>\n\n\n\n

Komanda atkl\u0101ja, ka elektriskie sign\u0101li jeb \"smailes\" tika raid\u012bti analogo, nevis digit\u0101lo sign\u0101lu veid\u0101. <\/p>\n\n\n\n

\u0160is atkl\u0101jums pav\u0113ra ce\u013cu uz skaidr\u0101ku izpratni par meh\u0101nismu. \u0160ie analogie sign\u0101li \u013c\u0101va viegl\u0101k regul\u0113t smadze\u0146u \u0137\u0113des sp\u0113ku.<\/p>\n\n\n\n

Tika atrasta ar\u012b molekula, kas regul\u0113 \u0161os elektriskos sign\u0101lus. Kv\u03b21 molekula papla\u0161in\u0101ja presinaptisko darb\u012bbu. <\/p>\n\n\n\n

\u0160\u012b molekula ne tikai regul\u0113 k\u0101lija str\u0101vu, bet ar\u012b pal\u012bdz veidot elektriskos sign\u0101lus. <\/p>\n\n\n\n

Iepriek\u0161, veicot eksperimentu, vi\u0146i izsl\u0113dza Kv\u03b21 molekulu pel\u0113m. Dr\u012bz vien rezult\u0101ti par\u0101d\u012bja pret\u0113ju reakciju, tika krasi ietekm\u0113ts pe\u013cu miega un atmi\u0146as cikls. <\/p>\n\n\n\n

Tas apstiprin\u0101ja molekulas pozit\u012bvo darb\u012bbu sist\u0113m\u0101.<\/p>\n\n\n\n

Papildus tam vi\u0146u p\u0113t\u012bjumi atkl\u0101j ar\u012b to, k\u0101 viens elektriskais impulss var p\u0101rnest vair\u0101ku bitu inform\u0101ciju, kas \u013cauj lab\u0101k kontrol\u0113t zemas frekvences sign\u0101lus. <\/p>\n\n\n\n

Tas noz\u012bm\u0113, ka m\u016bsu smadzenes ir daudz efekt\u012bv\u0101kas, nek\u0101 var iedom\u0101ties. Tehniski m\u016bsu smadzenes veic super skait\u013co\u0161anas uzdevumus pie zemas elektrisk\u0101s signaliz\u0101cijas. <\/p>\n\n\n\n

Vi\u0146u p\u0113t\u012bjumi \u013c\u0101va izm\u0113r\u012bt spriegumu un neirotransmiteru, izmantojot gaismu, kas savuk\u0101rt m\u0113r\u012bja elektriskos sign\u0101lus sinaptisko savienojumu viet\u0101s. <\/p>\n\n\n\n

Tas main\u012bja perspekt\u012bvu, k\u0101 ar\u012b papla\u0161in\u0101ja p\u0113t\u012bjumu loku molekul\u0101ro regulatoru jom\u0101, kam ir b\u016btiska noz\u012bme smadze\u0146u darb\u012bb\u0101.<\/p>\n\n\n\n

\u0160is atkl\u0101jums paver pavisam jaunu ce\u013cu farmaceitisko l\u012bdzek\u013cu izstr\u0101dei. Tas var\u0113tu pal\u012bdz\u0113t atkl\u0101t jaunas z\u0101\u013cu pieg\u0101des demences vai Alcheimera slim\u012bbas gad\u012bjum\u0101. <\/p>\n\n\n\n

Molekul\u0101rie regulatori var\u0113tu b\u016bt atsl\u0113ga, lai izmantotu visu smadze\u0146u sp\u0113ju. Daudzas neirolo\u0123iskas slim\u012bbas var\u0113tu iz\u0101rst\u0113t, ja tiktu atrasts pareizais smadze\u0146u metabolisma ce\u013c\u0161. <\/p>\n\n\n\n

K\u0101 saka, m\u0101c\u012b\u0161an\u0101s nekad neizsme\u013c pr\u0101tu, tas ir sp\u0113ks, kas var main\u012bt pasauli. \u0160is atkl\u0101jums, bez \u0161aub\u0101m, noved pie pavisam jauna l\u012bme\u0146a m\u0101c\u012b\u0161an\u0101s un sp\u0113ka to notur\u0113t.<\/p>\n\n\n\n

Lai uzzin\u0101tu vair\u0101k par vi\u0146u p\u0113t\u012bjumiem, skatiet t\u0101l\u0101k sniegto atsauci.<\/p>\n\n\n\n

Atsauce :<\/p>\n\n\n\n

In Ha Cho, Lauren C. Panzera, Morven Chin, Scott A. Alpizar, Genaro E. Olveda, Robert A. Hill, Michael B. Hoppa. K\u0101lija kan\u0101lu apak\u0161vien\u012bba Kv\u03b21 kalpo k\u0101 galvenais sinaptisk\u0101s veicin\u0101\u0161anas kontroles punkts. Proceedings of the National Academy of Sciences, 2020; 202000790.<\/p>\n\n\n\n

DOI: 10.1073\/pnas.2000790117<\/p>","protected":false},"excerpt":{"rendered":"

Katrai ma\u0161\u012bnai ir vad\u012bbas panelis da\u017e\u0101du funkciju, jo \u012bpa\u0161i iesl\u0113g\u0161anas un izsl\u0113g\u0161anas meh\u0101nisma, kontrolei. Vai k\u0101dreiz esat aizdom\u0101ju\u0161ies, ka ar\u012b m\u016bsu smadzen\u0113m ir t\u0101ds, ar kuru var kontrol\u0113t smadze\u0146u funkcijas? Jaunie p\u0113t\u012bjumi liecina, ka past\u0101v \"molekul\u0101r\u0101 poga\", kas regul\u0113 elektriskos sign\u0101lus smadzen\u0113s m\u0101c\u012b\u0161an\u0101s un jo \u012bpa\u0161i [...].<\/p>","protected":false},"author":4,"featured_media":12176,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[54,245,554],"yoast_head":"\nThe \u201cmolecular control knob\u201d that aids learning and memory - MTG<\/title>\n<meta name=\"description\" content=\"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/lv\/molekularni-nadzor-kljuc-mozgani\/\" \/>\n<meta property=\"og:locale\" content=\"lv_LV\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The \u201cmolecular control knob\u201d that aids learning and memory - MTG\" \/>\n<meta property=\"og:description\" content=\"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/lv\/molekularni-nadzor-kljuc-mozgani\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-25T11:30:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-22T14:11:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/a-molecular-control-knob-in-the-brain-that-aids-in-learning-and-memory.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1123\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The \u201cmolecular control knob\u201d that aids learning and memory - 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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