T\u0101p\u0113c zin\u0101tnieki padzi\u013cin\u0101ti p\u0113ta, lai sp\u0113tu atbild\u0113t uz \u0101rstu un pacientu jaut\u0101jumiem. <\/p>\n\n\n\n
Agr\u0101k m\u0113s piln\u012bb\u0101 izpratu\u0161i ka\u0146epju auga terapeitisko iedarb\u012bbu; tagad zin\u0101tnei ir j\u0101atbild uz jaut\u0101jumiem par endokanabino\u012bdu sist\u0113ma<\/strong>. <\/p>\n\n\n\n Apskat\u012bsim, kas jau ir zin\u0101ms.<\/p>\n\n\n\n Port\u0101ls Endokanabino\u012bdu sist\u0113ma (ES)<\/strong> ir nervu sist\u0113mas modulators, kas darbojas k\u0101 t\u012bkls vis\u0101 organism\u0101, centr\u0101l\u0101s nervu sist\u0113mas regulators. <\/p>\n\n\n\n Pieaugu\u0161\u0101 cilv\u0113ka endokanabino\u012bdu sist\u0113mai ir liela ietekme uz neironu darb\u012bbas modul\u0101ciju - t\u0101 ietekm\u0113 daudzus kognit\u012bvos un fiziolo\u0123iskos procesus, piem\u0113ram, izsalkumu, miegu, atmi\u0146u, trauksmi, im\u016bnsist\u0113mu, motoriku un citus. <\/p>\n\n\n\n Port\u0101ls ES<\/strong> ir komandas sp\u0113l\u0113t\u0101js, kas nedarbojas k\u0101 izol\u0113ta sist\u0113ma; t\u0101 ir saist\u012bta ar da\u017e\u0101d\u0101m sign\u0101lu kask\u0101d\u0113m no cit\u0101m organisma sist\u0113m\u0101m.<\/p>\n\n\n\n Eiropas skolu veido tr\u012bs galvenie komponenti - ES. kanabino\u012bdu receptori<\/strong>, endog\u0113nie kanabino\u012bdi<\/strong>, un enz\u012bmi<\/strong> atbild\u012bgs par endokanabino\u012bdu molekulu sint\u0113zi un no\u0101rd\u012b\u0161anu. <\/p>\n\n\n\n Port\u0101ls endog\u0113nie kanabino\u012bdi ir<\/strong> molekulu veids, ko ra\u017eo m\u016bsu organisms, un tas ir sastopams ar\u012b dab\u0101, piem\u0113ram, ka\u0146epju augi. <\/p>\n\n\n\n M\u016bsdien\u0101s zin\u0101tnei ir zin\u0101mas tr\u012bs da\u017e\u0101das molekulas, kas sp\u0113j aktiviz\u0113t kanabino\u012bdu receptorus - 2-AG un anandam\u012bds (AEA), kas ir attiec\u012bgi 2-arahidonoilglicer\u012bna un N-arahidonoiletanolam\u012bna sa\u012bsin\u0101tie nosaukumi; abas ir klasific\u0113tas k\u0101 endog\u0113nie kanabino\u012bdi ar lip\u012bdiem l\u012bdz\u012bgu strukt\u016bru. <\/p>\n\n\n\n Tre\u0161ais, ko sauc par N- arahidonoil dopam\u012bnu jeb vienk\u0101r\u0161i NADA, ar\u012b ir lip\u012bdu strukt\u016bra un ar\u012b mijiedarbojas ar kanabino\u012bdu receptoriem..<\/strong> <\/p>\n\n\n\n Pirmie divi sp\u0113j piesaist\u012bt un aktiviz\u0113t vair\u0101kus G-prote\u012bnu saist\u012btos sign\u0101lce\u013cus - receptorus, jonu kan\u0101lus un kodolreceptorus, no kuriem p\u0113d\u0113jie ir atbild\u012bgi par stero\u012bdu un vairogdziedzera hormonu noteik\u0161anu. <\/p>\n\n\n\n Papildus molekul\u0101r\u0101s strukt\u016bras l\u012bdz\u012bb\u0101m, 2-AG <\/strong>un anandam\u012bds<\/strong> ir da\u017e\u0101das lomas ES,<\/strong> ar at\u0161\u0137ir\u012bgiem bio\u0137\u012bmiskiem cikliem organism\u0101 - atkar\u012bbas gad\u012bjum\u0101. 2012. gad\u0101 tika public\u0113ts recenz\u0113ts raksts par anandam\u012bda lomu \u0161izofr\u0113nijas gad\u012bjum\u0101.<\/a>.\u00a0<\/p>\n\n\n\n Vair\u0101ki p\u0113t\u012bjumi liecina, ka endog\u0113nos kanabino\u012bdus organisms sintez\u0113 p\u0113c vajadz\u012bbas, citiem v\u0101rdiem sakot, \"p\u0113c piepras\u012bjuma\". <\/p>\n\n\n\n Tas noz\u012bm\u0113, ka m\u0113s visu laiku nesintez\u0113jam endog\u0113nos kanabino\u012bdus, tie neveidojas asinsrit\u0113, gaidot, kad tos izsauks, bet tiek sintez\u0113ti noteikt\u0101 viet\u0101, kad tas ir nepiecie\u0161ams.<\/p>\n\n\n\n Abi kanabino\u012bdu receptori<\/strong> \u0161odien zin\u0101ms, CB1<\/strong> un CB2<\/strong> abi ir ar G-prote\u012bnu saist\u012bti receptori. <\/p>\n\n\n\n Receptoriem ir da\u017e\u0101das funkcijas, tie sp\u0113j mijiedarboties ar da\u017e\u0101d\u0101m molekul\u0101m un aktiviz\u0113t da\u017e\u0101dus sign\u0101lce\u013cus, un tas var izrais\u012bt specifisku vai at\u0161\u0137ir\u012bgu biolo\u0123isko iedarb\u012bbu.<\/p>\n\n\n\n Liel\u0101k\u0101 da\u013ca CB1 receptoru atrodas centr\u0101laj\u0101 nervu sist\u0113m\u0101, ta\u010du tos var atrast ar\u012b t\u0101dos org\u0101nos k\u0101 aknas, \u0101da un taukaudi. <\/p>\n\n\n\n Nervu sist\u0113m\u0101 CB1 ir nov\u0113rots vair\u0101kos sinaptiskos termin\u0101los, un tam ir svar\u012bga loma sinaptisk\u0101s transmisijas modul\u0113\u0161an\u0101. <\/p>\n\n\n\n \u0160im receptoram piem\u012bt ar\u012b \u012bpa\u0161\u012bba heterodimeriz\u0113ties - saist\u012bties ar da\u017e\u0101d\u0101m sav\u0101m strukt\u016br\u0101m - ar citiem G-prote\u012bna saist\u012btajiem receptoriem, piem\u0113ram, dopam\u012bna D2, hipokret\u012bna un opio\u012bdu receptoriem. Faktiski da\u017ei p\u0113t\u012bjumi liecina, ka ka ka\u0146epes pal\u012bdz mazin\u0101t s\u0101pes, samazinot opio\u012bdu devas.<\/a>\u00a0<\/p>\n\n\n\n CB2 receptori ir pla\u0161i sastopami im\u016bnsist\u0113mas \u0161\u016bn\u0101s, un, neraugoties uz to, ka tie ir izteikti \u0160o receptoru var atrast da\u017e\u0101dos org\u0101nos, piem\u0113ram, akn\u0101s, lies\u0101, aizku\u0146\u0123a dziedzer\u012b, resnaj\u0101 zarn\u0101 un kaulos. <\/p>\n\n\n\n P\u0113tnieki CB2 receptoru aktiviz\u0101ciju raksturo k\u0101 pretiekaisuma faktoru iekaisuma scen\u0101rijos. CB1 ir galvenais anandam\u012bda un THC receptors. <\/p>\n\n\n\n Gan anandam\u012bds, gan THC tiek klasific\u0113ti k\u0101 CB1 receptoru da\u013c\u0113jie agonisti, kas noz\u012bm\u0113, ka molekul\u0101m ir \u013coti zema efektivit\u0101te, izraisot receptoru reakciju, kas tie\u0161i ietekm\u0113 terapeitisko iedarb\u012bbu. <\/p>\n\n\n\n Tikm\u0113r 2-AG, kas smadzen\u0113s ir daudz izplat\u012bt\u0101ks nek\u0101 anandam\u012bds, tiek klasific\u0113ts k\u0101 \u013coti efekt\u012bvs abu receptoru - CB1 un CB2 - agonists, kas sp\u0113j piesaist\u012bties receptoriem, aktiviz\u0113jot tos un izraisot augsta l\u012bme\u0146a biolo\u0123isko reakciju. <\/p>\n\n\n\n Savuk\u0101rt CBD tiek klasific\u0113ts k\u0101 abu receptoru antagonists, kas noz\u012bm\u0113, ka molekula savienojas ar receptoru, neaktiviz\u0113jot to, un tas ne\u013cauj cit\u0101m molekul\u0101m savienoties un aktiviz\u0113t receptoru.<\/p>\n\n\n\n T\u0101 k\u0101 smadzen\u0113s ir liels endokanabino\u012bdu receptoru skaits, da\u017eas gar\u012bg\u0101s slim\u012bbas ir saist\u012btas ar endokanabino\u012bdu sist\u0113mas disregul\u0101cijas trauc\u0113jumiem un \u0123en\u0113tisko polimorfismu, piem\u0113ram, psihoze, \u0161izofr\u0113nija, trauksme, depresija un autisms. <\/p>\n\n\n\n Zin\u0101tnieki ir m\u0113\u0123in\u0101ju\u0161i saprast un noskaidrot prec\u012bzu saist\u012bbu starp iesp\u0113jam\u0101m mut\u0101cij\u0101m endokanabino\u012bdu sist\u0113m\u0101 un \u0161\u012bm slim\u012bb\u0101m.<\/p>\n\n\n\n \u0160odien pacientiem ir iesp\u0113jams nosl\u0113gt l\u012bgumu ar uz\u0146\u0113mums, lai analiz\u0113tu to \u0123en\u0113tisko kodu.<\/a> un ieg\u016bt visas iesp\u0113jam\u0101s mut\u0101cijas to endokanabino\u012bdu sist\u0113mas kodu un saprast, k\u0101 vi\u0146u organisms r\u012bkoties ar ka\u0146epju molekulas, piem\u0113ram, THC, CBD un daudzi citi. <\/p>\n\n\n\n \u0160obr\u012bd nav daudz zin\u0101\u0161anu par CB2 receptora alosterisko modul\u0101ciju, bet CB1 receptoram ir zin\u0101mi vair\u0101ki alosteriskie modulatori. <\/p>\n\n\n\n Alosteriskie modulatori sp\u0113j main\u012bt receptora kin\u0113tiku un\/vai efektivit\u0101ti - t\u0101 ir enz\u012bmu regul\u0101cija, ko raksturo efektora molekulas piesaiste citam re\u0123ionam, kas at\u0161\u0137iras no fermenta akt\u012bv\u0101s vietas, \u0161o sekund\u0101ro vietu sauc par ortostatisko vietu.<\/p>\n\n\n\n Svar\u012bgi piemin\u0113t, ka CBD ir CB1 negat\u012bvs alosterisks modulators, kas samazina CB1 aktiviz\u0101ciju ar THC. <\/p>\n\n\n\n Citiem v\u0101rdiem sakot, THC iedarb\u012bbu samazina CBD iedarb\u012bba. THC psihoaktivit\u0101te ir maz\u0101ka, ja to lieto kop\u0101 ar CBD.<\/p>\n\n\n\n K\u0101 redzat, endokanabino\u012bdu sist\u0113ma neb\u016bt nav vienk\u0101r\u0161a, no otras puses, t\u0101 ir \u013coti sare\u017e\u0123\u012bta sist\u0113ma, kas atrodas gandr\u012bz vis\u0101 m\u016bsu organism\u0101. <\/p>\n\n\n\n Tas ir svar\u012bgs signaliz\u0101cijas ce\u013cu regulators, un, ac\u012bmredzot. ES<\/strong> ir zin\u0101m\u0101 m\u0113r\u0101 saist\u012bti biolo\u0123isk\u0101 l\u012bmen\u012b, ko zin\u0101tnieki joproj\u0101m piln\u012bb\u0101 neizprot. <\/p>\n\n\n\n Ar\u012b eksog\u0113nie kanabino\u012bdi - kanabino\u012bdi, kurus cilv\u0113ka organisms nera\u017eo - ir \u013coti svar\u012bgas endokanabino\u012bdu sist\u0113mas molekulas, ta\u010du par t\u0101m tiks run\u0101ts tikai n\u0101kamaj\u0101 noda\u013c\u0101 \"Ka\u0146epju pasaule\".\u00a0<\/p>\n\n\n\n LU, H.-C.; MACKIE, K. P\u0101rskats par endokanabino\u012bdu sist\u0113mu. Biolo\u0123isk\u0101 psihiatrija: Kognit\u012bv\u0101 neirozin\u0101tne un neirovizualiz\u0101cija<\/strong>, 1 pirms. 2020.<\/p>\n\n\n\n MARKUS LEWEKE, F. Anandam\u012bda disfunkcija prodrom\u0101l\u0101s un konstat\u0113t\u0101s psihozes gad\u012bjum\u0101. Pa\u0161reiz\u0113jais farm\u0101cijas dizains<\/strong>, v. 18, n. 32, p. 5188-5193, 2012. gada 1. novembris. <\/p>\n\n\n\n ___<\/p>\n\n\n\n Vai jums patika \u0161aj\u0101 rakst\u0101 iek\u013caut\u0101 infografika? J\u016bs varat izveidot l\u012bdz\u012bgas infografikas vietn\u0113 Mind the Graph, varat s\u0101kt izmantot jau tagad.<\/a> <\/p>\n\n\n\n \u0160\u012b platforma var pal\u012bdz\u0113t jums izveidot infografikas, piem\u0113ram, k\u0101 \u0161aj\u0101 rakst\u0101. J\u016bs varat izmantot neirolo\u0123ija,<\/a> kardiolo\u0123ija,<\/a> endokrinolo\u0123ija<\/a>, ginekolo\u0123ija<\/a>, urolo\u0123ija<\/a>, un daudzi citi<\/a>. Ja jums ir nepiecie\u0161ama pal\u012bdz\u012bba, m\u0113s esam gatavi jums pal\u012bdz\u0113t, sazinieties ar mums<\/a>!<\/p>","protected":false},"excerpt":{"rendered":" P\u0113d\u0113j\u0101 desmitgad\u0113 \u0101rst\u0113\u0161ana ar ka\u0146ep\u0113m ir guvusi lielu zin\u0101tnieku un medi\u0137u uzman\u012bbu vis\u0101 pasaul\u0113. Ir pier\u0101d\u012bts, ka \u0101rst\u0113\u0161anas atbildes reakcijas ir daudz lab\u0101kas sal\u012bdzin\u0101jum\u0101 ar parastaj\u0101m z\u0101l\u0113m. P\u0113c tam endokanabino\u012bdu sist\u0113ma ir piesaist\u012bjusi uzman\u012bbu eksponenci\u0101l\u0101 temp\u0101; p\u0113tnieki ir ap\u0146\u0113mu\u0161ies lab\u0101k izprast, k\u0101 \u0161\u012b sist\u0113ma darbojas un k\u0101 t\u0101 [...].<\/p>","protected":false},"author":4,"featured_media":12140,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959],"tags":[819,554,964,775,820],"yoast_head":"\n![\"\"](\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/endogenous-cannabinoids-1024x1024.png\")
<\/a><\/figure><\/div>\n\n\n\n <\/s>daudz zem\u0101kos l\u012bme\u0146os nek\u0101 CB1, CB2 ir ar\u012b neironu \u0161\u016bn\u0101s. <\/p>\n\n\n\n![\"\"](\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/endocannabinoid-system.png\")
<\/a><\/figure><\/div>\n\n\n\n