{"id":12121,"date":"2021-01-11T11:05:53","date_gmt":"2021-01-11T13:05:53","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12121"},"modified":"2023-01-05T14:52:03","modified_gmt":"2023-01-05T17:52:03","slug":"cause-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lv\/alcheimera-slimibas-celonis\/","title":{"rendered":"Jauna teorija m\u0113\u0123ina izskaidrot Alcheimera slim\u012bbas c\u0113loni"},"content":{"rendered":"

M\u016bsdien\u0101s vair\u0101k nek\u0101 puse demences gad\u012bjumu tiek klasific\u0113ti k\u0101 Alcheimera slim\u012bba - hroniska neirode\u0123enerat\u012bva slim\u012bba, kas pak\u0101peniski ietekm\u0113 cilv\u0113ka izzi\u0146as sp\u0113jas un atmi\u0146u. <\/p>\n\n\n\n

L\u012bdz \u0161im tika uzskat\u012bts, ka to izraisa \u0123en\u0113tiski un noveco\u0161an\u0101s faktori, par slim\u012bbas galvenajiem vaininiekiem un \u013caundariem tiek uzskat\u012btas senil\u0101s pl\u0101ksn\u012btes un neirofibrilo plankumi, kas izraisa neiroinflamm\u0101ciju un, sec\u012bgi, neironu n\u0101vi. <\/p>\n\n\n\n

Tom\u0113r jauna teorija par Alcheimera slim\u012bbas c\u0113lo\u0146iem iemirdz gaismu medic\u012bnas p\u0113t\u012bjumu debes\u012bs. <\/p>\n\n\n\n

Teorija liecina, ka \u0123en\u0113tika un noveco\u0161an\u0101s nav vien\u012bgie faktori, kas izraisa amilo\u012bda - prote\u012bna, kas uzkr\u0101jas starp neironiem un izraisa Alcheimera slim\u012bbu, - veido\u0161anos, bet t\u0101 var izrais\u012bt ar\u012b reakciju uz mikrobu infekciju.  <\/p>\n\n\n\n

Apl\u016bkosim tuv\u0101k neirolo\u0123isko skalu, lai saprastu visu to, kas notiek smadzen\u0113s ar Alcheimera slim\u012bbu. Notiek divas galven\u0101s par\u0101d\u012bbas.<\/p>\n\n\n\n

Olbaltumviela tau ir atbild\u012bga par stabilit\u0101tes uztur\u0113\u0161anu, sniedzot atbalstu mikrotubul\u0101m neironu iek\u0161ien\u0113. Smadzen\u0113s, kas cie\u0161 no \u0161\u012b st\u0101vok\u013ca, tau bio\u0137\u012bmiski p\u0101rveidojas reakcij\u0101, ko sauc par hiperfosforil\u0101ta reakciju. <\/p>\n\n\n\n

\u0160o izmai\u0146u rezult\u0101t\u0101 neirona iek\u0161ien\u0113 veidojas ne\u0161\u0137\u012bsto\u0161u olbaltumvielu gabali\u0146i, kas izjauc visu sist\u0113mu un nogalina neirona \u0161\u016bnas. <\/p>\n\n\n\n

\u0160ie ne\u0161\u0137\u012bsto\u0161ie tau olbaltumvielu gabali\u0146i apvienojas viens ar otru, veidojot neirofibril\u0101ros plankumus.<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Port\u0101ls senila pl\u0101ksn\u012btes<\/strong> ir izgatavoti no amilo\u012bda-\u03b2 pept\u012bdi<\/strong>. Neironu membr\u0101n\u0101s eso\u0161ais prote\u012bns (pre-amilo\u012bds) tiek sa\u0161\u0137elts, k\u0101 rezult\u0101t\u0101 \u0101rpus neironiem veidojas br\u012bvi amilo\u012bda-\u03b2 gabali*. <\/p>\n\n\n\n

\u0160os gabali\u0146us no \u0101r\u0113j\u0101s neironu vides vajadz\u0113tu att\u012br\u012bt \u012bpa\u0161\u0101m \u0161\u016bn\u0101m un fermentiem, veicot fagocitozi, ta\u010du \u0123en\u0113tisku vai noveco\u0161an\u0101s faktoru d\u0113\u013c \u0161is process nenotiek pietiekami efekt\u012bvi, k\u0101 rezult\u0101t\u0101 rodas br\u012bvi ne\u0161\u0137\u012bsto\u0161u amilo\u012bda-\u03b2 olbaltumvielu gabali\u0146i, kas s\u0101k apvienoties pl\u0101ksn\u012bt\u0113s.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Amilo\u012bda pl\u0101ksn\u012btes ir visvair\u0101k p\u0113t\u012btas un apspriestas k\u0101 Alcheimera slim\u012bbas c\u0113lonis. Ta\u010du zin\u0101tnieki ar\u012b apstiprina, ka neirofibril\u0101rie plankumi ir tie\u0161i saist\u012bti ar slim\u012bbas progres\u0113\u0161anu.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Zin\u0101tnieki atrada amilo\u012bda sabl\u012bv\u0113jumus ar\u012b vesel\u0101s smadzen\u0113s. Tas noz\u012bm\u0113, ka ar\u012b vesel\u0101s vec\u0101s smadzen\u0113s att\u012br\u012b\u0161an\u0101s process k\u013c\u016bst maz\u0101k efekt\u012bvs, bet ne tik \u013coti k\u0101 smadzen\u0113s ar Alcheimera slim\u012bbu.<\/p>\n\n\n\n

T\u0101p\u0113c Alcheimera slim\u012bbu raksturo liels skaits \u0161o senilaino pl\u0101ksn\u012b\u0161u un neirofibrilo plankumu, kas smadzen\u0113m k\u013c\u016bst \u0101rk\u0101rt\u012bgi toksiski un maina sinapses efektivit\u0101ti un kvalit\u0101ti. <\/p>\n\n\n\n

Saslimu\u0161ajiem cilv\u0113kiem ir t\u0101di simptomi k\u0101 atmi\u0146as zudums, apjukums saist\u012bb\u0101 ar laiku un atra\u0161an\u0101s vietu, depresija, trauksme, valodas un komunik\u0101cijas probl\u0113mas, garast\u0101vok\u013ca nestabilit\u0101te un citi.<\/p>\n\n\n\n

Jaunaj\u0101 ierosin\u0101taj\u0101 teorij\u0101<\/strong>, amilo\u012bda pl\u0101ksn\u012btes ir smadze\u0146u aizsardz\u012bbas meh\u0101nisms pret mikrobu infekciju. <\/p>\n\n\n\n

Amilo\u012bda-\u03b2 g\u0113ns ir sastopams liel\u0101 da\u013c\u0101 mugurkaulnieku, un tas ir saglab\u0101jies da\u017e\u0101d\u0101s sug\u0101s vair\u0101ku paaud\u017eu garum\u0101, kas noz\u012bm\u0113, ka tam vajadz\u0113tu b\u016bt noder\u012bgam un svar\u012bgam m\u016bsu organismam, nevis tikai darboties k\u0101 kait\u012bgam - ja tas neb\u016btu der\u012bgs vai noder\u012bgs, g\u0113ns evol\u016bcijas ce\u013c\u0101 jau sen b\u016btu zudis.<\/p>\n\n\n\n

Zin\u0101tnieki mekl\u0113ja t\u016bksto\u0161iem ar Alcheimera slim\u012bbu slimu cilv\u0113ku p\u0113cn\u0101ves smadze\u0146u. <\/p>\n\n\n\n

Lai gan slikto apst\u0101k\u013cu d\u0113\u013c vi\u0146i sask\u0101r\u0101s ar gr\u016bt\u012bb\u0101m analiz\u0113t \u0161o smadze\u0146u tipus, vi\u0146i var\u0113ja izp\u0113t\u012bt un apkopot inform\u0101ciju, lai v\u0113l\u0101k ierosin\u0101tu da\u017eus iesp\u0113jamos mikrobu ierosin\u0101t\u0101jus. <\/p>\n\n\n\n

\u0160ie ierosin\u0101t\u0101ji ir aizsardz\u012bbas meh\u0101nismi pret da\u017eiem cilv\u0113ka herpesv\u012brusu veidiem, piem\u0113ram, herpesv\u012brusu 1, 6A un 7, un trim bakt\u0113rij\u0101m, Hlam\u012bdiju pneimonija<\/em>, Borrelia burgdorferi<\/em>, Porphyromonas gingivalis<\/em>.<\/p>\n\n\n\n

Teorija ir t\u0101da, ka beta amilo\u012bdam s\u0101kotn\u0113ji ir aizsargfunkcija, kas aiztur mikrobus, kuri p\u0101rvietojas uz smadzen\u0113m, apturot iesp\u0113jamu infekciju vai slim\u012bbu. <\/p>\n\n\n\n

K\u0101 min\u0113ts, noveco\u0161an\u0101s faktoru d\u0113\u013c smadzenes zaud\u0113 sp\u0113ju efekt\u012bvi att\u012br\u012bt amilo\u012bdus. T\u0101d\u0113j\u0101di priek\u0161stats par amilo\u012bda funkciju visu laiku var\u0113tu b\u016bt nepareizs; iesp\u0113jams, tas ir iesaist\u012bts sava veida antimikrobi\u0101l\u0101 aizsardz\u012bb\u0101 pret smadze\u0146u iebruc\u0113jiem, jo tiek klasific\u0113ts k\u0101 antimikrobi\u0101ls pept\u012bds.<\/p>\n\n\n\n

Zin\u0101tnieki ir guvu\u0161i pozit\u012bvus rezult\u0101tus, m\u0113\u0123inot pier\u0101d\u012bt, ka \u03b2-amilo\u012bds var nogalin\u0101t mikroorganismus, kas izraisa da\u017eas izplat\u012btas slim\u012bbas. <\/p>\n\n\n\n

Turkl\u0101t cit\u0101 p\u0113t\u012bjum\u0101, kas tika uzs\u0101kts 2007. gad\u0101 un kuru paredz\u0113ts pabeigt 2022. gad\u0101 Kolumbijas Universit\u0101t\u0113 \u0145ujork\u0101, tiek test\u0113ts pretv\u012brusu medikaments pacientiem, kuri slimo ar kancerozi. h<\/s>erpes simplex v\u012brusu 1 un vieglu Alcheimera slim\u012bbu, lai noskaidrotu, vai z\u0101les var pal\u0113nin\u0101t slim\u012bbas progres\u0113\u0161anu. <\/p>\n\n\n\n

Pagaid\u0101m vien\u012bgais, ko varam dar\u012bt, ir cer\u0113t uz lab\u0101ko un gaid\u012bt rezult\u0101tus.<\/p>\n\n\n\n

\u0160\u012b jaun\u0101 teorija joproj\u0101m nav labi pie\u0146emta vis\u0101 zin\u0101tnieku sabiedr\u012bb\u0101. Daudzi zin\u0101tnieki apgalvo, ka pat tad, ja \u0161\u012b jaun\u0101 teorija tiks pier\u0101d\u012bta, galvenais slim\u012bbas c\u0113lonis joproj\u0101m b\u016bs \u0123en\u0113tiskie faktori un sliktas mut\u0101cijas. <\/p>\n\n\n\n

Alcheimera slim\u012bba joproj\u0101m ir slim\u012bba, par kuras patiesajiem c\u0113lo\u0146iem ir \u013coti maz zin\u0101tnisku zin\u0101\u0161anu; nav ne \u0101rst\u0113\u0161anas, ne terapeitisk\u0101s \u0101rst\u0113\u0161anas iesp\u0113ju. Ja \u0161\u012b teorija izr\u0101d\u012bsies patiesa, tas var\u0113tu b\u016bt pirmais solis ce\u013c\u0101 uz lab\u0101ku \u0101rst\u0113\u0161anu. Uz priek\u0161u, zin\u0101tne!<\/p>\n\n\n\n

Atsauces<\/strong><\/p>\n\n\n\n

ABBOTT, A. Vai da\u017eos Alcheimera slim\u012bbas gad\u012bjumos infekcijas ir Alcheimera slim\u012bbas aizs\u0101kums? Daba<\/strong>, v. 587, n. 7832, p. 22-25, 4 nov. 2020. gada 4. novembris.<\/p>\n\n\n\n

CEC\u00cd, K. et al. Biomar\u0137ieri Alcheimera slim\u012bbas gad\u012bjum\u0101. Geriatrija, gerontolo\u0123ija un noveco\u0161an\u0101s<\/strong>, t. 6, n. 3, p. 273-282, 2012. gads.<\/p>\n\n\n\n

MAKIN, S. Amilo\u012bda hipot\u0113ze ties\u0101. Daba<\/strong>, v. 559, n. 7715, p. S4-S7, 25 j\u016bl. 2018.<\/p>\n\n\n\n

YOO, K.-Y.; PARK, S.-Y. Terpeno\u012bdi k\u0101 potenci\u0101li pret Alcheimera slim\u012bbu terapeitiskie l\u012bdzek\u013ci. Molekulas<\/strong>, v. 17, n. 3, p. 3524-3538, mar. 2012.<\/p>\n\n\n\n

___
Ja jums, t\u0101pat k\u0101 man, ir nepiecie\u0161ams izveidot infografiku zin\u0101tniskiem m\u0113r\u0137iem, Mind the Graph varat izveidot jebk\u0101da veida infografiku, kas jums nepiecie\u0161ama un ko v\u0113laties. \u0160\u012b platforma ir \u0161eit, lai p\u0101rv\u0113rstu zin\u0101tniekus par dizaineriem un palielin\u0101tu vi\u0146u ietekmi! Pievienojieties mums platform\u0101, klik\u0161\u0137iniet \u0161eit<\/a>!<\/p>","protected":false},"excerpt":{"rendered":"

M\u016bsdien\u0101s vair\u0101k nek\u0101 puse demences gad\u012bjumu tiek klasific\u0113ti k\u0101 Alcheimera slim\u012bba - hroniska neirode\u0123enerat\u012bva slim\u012bba, kas pak\u0101peniski ietekm\u0113 cilv\u0113ka izzi\u0146as sp\u0113jas un atmi\u0146u. L\u012bdz \u0161im tika uzskat\u012bts, ka to izraisa \u0123en\u0113tiski un noveco\u0161an\u0101s faktori, bet par slim\u012bbas galvenajiem vaininiekiem tiek uzskat\u012bti [...].<\/p>","protected":false},"author":4,"featured_media":12125,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[213,554,964,136],"yoast_head":"\nNew Theory Tries to Explain The Cause of Alzheimer\u2019s<\/title>\n<meta name=\"description\" content=\"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/lv\/cauza-bolii-alzheimer\/\" \/>\n<meta property=\"og:locale\" content=\"lv_LV\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Theory Tries to Explain The Cause of Alzheimer\u2019s\" \/>\n<meta property=\"og:description\" content=\"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/lv\/cauza-bolii-alzheimer\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-11T13:05:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-05T17:52:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/new-theory-tries-to-explain-the-cause-of-alzheimers-disease.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1110\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New Theory Tries to Explain The Cause of Alzheimer\u2019s","description":"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/lv\/cauza-bolii-alzheimer\/","og_locale":"lv_LV","og_type":"article","og_title":"New Theory Tries to Explain The Cause of Alzheimer\u2019s","og_description":"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.","og_url":"https:\/\/mindthegraph.com\/blog\/lv\/cauza-bolii-alzheimer\/","og_site_name":"Mind the Graph Blog","article_published_time":"2021-01-11T13:05:53+00:00","article_modified_time":"2023-01-05T17:52:03+00:00","og_image":[{"width":1110,"height":600,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/new-theory-tries-to-explain-the-cause-of-alzheimers-disease.png","type":"image\/png"}],"author":"Fabricio Pamplona","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabricio Pamplona","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/","url":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/","name":"New Theory Tries to Explain The Cause of Alzheimer\u2019s","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2021-01-11T13:05:53+00:00","dateModified":"2023-01-05T17:52:03+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3"},"description":"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/#breadcrumb"},"inLanguage":"lv","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/ro\/cauza-bolii-alzheimer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"New Theory Tries to Explain The Cause of Alzheimer\u2019s Disease"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"lv"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3","name":"Fabricio Pamplona","image":{"@type":"ImageObject","inLanguage":"lv","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","caption":"Fabricio Pamplona"},"description":"Fabricio Pamplona is the founder of Mind the Graph - a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/lv\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/posts\/12121"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/comments?post=12121"}],"version-history":[{"count":3,"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/posts\/12121\/revisions"}],"predecessor-version":[{"id":26048,"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/posts\/12121\/revisions\/26048"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/media\/12125"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/media?parent=12121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/categories?post=12121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lv\/wp-json\/wp\/v2\/tags?post=12121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}