{"id":8713,"date":"2019-04-18T18:07:31","date_gmt":"2019-04-18T21:07:31","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8713"},"modified":"2022-10-18T08:24:00","modified_gmt":"2022-10-18T11:24:00","slug":"brain-damage-pig-brains-alive-hours-death","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/smegenu-pazeidimas-kiauliu-smegenys-gyvos-valandos-mirtis\/","title":{"rendered":"Smegen\u0173 pa\u017eeidimas: infografikas, padedantis suprasti nauj\u0105j\u012f \"Nature\" straipsn\u012f"},"content":{"rendered":"

Jeilio universiteto mokslininkai kelias valandas po mirties kiauli\u0173 smegenis laik\u0117 gyvas u\u017e k\u016bno rib\u0173. Straipsnis Smegen\u0173 kraujotakos ir l\u0105steli\u0173 funkcij\u0173 atk\u016brimas pra\u0117jus kelioms valandoms po skrodimo<\/strong> paai\u0161kina eksperiment\u0105, kurio metu buvo naudojamos kiauli\u0173 smegenys ir kuris gali pad\u0117ti i\u0161ry\u0161kinti smegen\u0173 pa\u017eeidim\u0173 tyrimus. \u017durnalas \"Nature\u00a0paskelbta <\/a>dokument\u0105 baland\u017eio 17 d.<\/p>\n

\"Did\u017ei\u0105j\u0105 \u017emonijos istorijos dal\u012f mirtis buvo labai paprasta.\"<\/em> sako Christofas Kochas. Jis yra Aleno smegen\u0173 mokslo instituto Sietle, Va\u0161ingtono valstijoje, prezidentas ir vyriausiasis mokslininkas. \"Dabar turime kelti klausim\u0105, kas yra negr\u012f\u017etama.\"\u00a0<\/em><\/p>\n

\u0160iose smegenyse n\u0117ra jokio ry\u0161io tarp neuron\u0173, tod\u0117l nebuvo s\u0105mon\u0117s. Ta\u010diau l\u0105stel\u0117s buvo gyvos - ir vien tai yra labai svarbus atradimas.<\/p>\n

\"Anks\u010diau buvo nustatyta, kad i\u0161 esm\u0117s per kelias minutes l\u0105stel\u0117se prasideda l\u0105steli\u0173 \u017e\u016bties procesas\".<\/em>\u00a0spaudos konferencijoje sak\u0117 tyrimui vadovav\u0119s Jeilio universiteto neurologas Nenadas Sestanas. \"Parod\u0117me, kad l\u0105steli\u0173 \u017e\u016btis vyksta palaipsniui, o kai kuriuos i\u0161 \u0161i\u0173 proces\u0173 galima atid\u0117ti, i\u0161saugoti ar net pakeisti.\"<\/em><\/p>\n

Smegen\u0173 pa\u017eeidimo eksperimentas<\/strong><\/h3>\n

Pasak \u017eurnalo \"Nature Magazine\", tyr\u0117jai patikrino, kaip smegenys veik\u0117 \u0161e\u0161ias valandas. Jie nustat\u0117, kad neuronai ir kitos smegen\u0173 l\u0105stel\u0117s v\u0117l prad\u0117jo vykdyti \u012fprastas med\u017eiag\u0173 apykaitos funkcijas, pavyzd\u017eiui, vartoti cukr\u0173 ir gaminti anglies dioksid\u0105. Be to, atrod\u0117, kad smegen\u0173 imunin\u0117 sistema veikia. Atskir\u0173 l\u0105steli\u0173 ir smegen\u0173 sekcij\u0173 strukt\u016bros buvo i\u0161likusios. Prie\u0161ingai, kontrolini\u0173 smegen\u0173, kurios negavo maistini\u0173 med\u017eiag\u0173 ir deguonies turtingo tirpalo, l\u0105stel\u0117s suiro. O kai mokslininkai apdorot\u0173 smegen\u0173 audini\u0173 m\u0117ginius paveik\u0117 elektra, jie nustat\u0117, kad atskiri neuronai vis dar gali perduoti signal\u0105.<\/p>\n

Mokslininkai suk\u016br\u0117 sistem\u0105 \"BrainEx\", specialiai sukurt\u0105 tam, kad susilpnint\u0173 kai kuriuos procesus, lemian\u010dius pomirtini\u0173 smegen\u0173 audini\u0173 irim\u0105. Sistema apima tirpalo, vadinamo BEx perfuzatu, pumpavim\u0105. Tirpalas yra patentuotas apsaugini\u0173, stabilizuojan\u010di\u0173 ir kontrastini\u0173 med\u017eiag\u0173 mi\u0161inys, kuris veikia kaip kraujo pakaitalas. Perfuzate taip pat yra chemini\u0173 med\u017eiag\u0173, kurios stabdo k\u016bno audini\u0173 oksidacij\u0105, stabdo apoptoz\u0119. Jame taip pat yra nervin\u0117s veiklos blokatoriaus, kurio paskirtis yra dvejopa. Jie pumpavo tirpal\u0105 \u012f izoliuot\u0173 smegen\u0173 pagrindines arterijas esant normaliai k\u016bno temperat\u016brai.<\/p>\n

 <\/p>\n

\"kiaul\u0117s\"<\/a>
Straipsnio paveiksl\u0117lyje parodyta, kaip prie BEx prietaiso buvo prijungtos visos smegenys. Kiaul\u0117s smegenys prie perfuzijos sistemos buvo prijungtos arterin\u0117mis linijomis.\u00a0<\/strong><\/figcaption><\/figure>\n

 <\/p>\n

Tyr\u0117jai naudojo apie 300 kiauli\u0173 galv\u0173 i\u0161 JAV \u017dem\u0117s \u016bkio departamento skerdyklos. Optimizavusi technologij\u0105, komanda prie \"BrainEx\" sistemos prijung\u0117 32 kiauli\u0173 smegenis. Jie prijung\u0117 smegenis pra\u0117jus 4 valandoms po to, kai kiaul\u0117s buvo nu\u017eudytos, ir i\u0161\u0117m\u0119 smegenis i\u0161 kaukoli\u0173. \u0160is kompiuterizuotas siurbli\u0173, \u0161ildytuv\u0173 ir filtr\u0173 tinklas \u0161e\u0161ias valandas kontroliavo sraut\u0105, temperat\u016br\u0105 ir patentuot\u0105 perfuzato tirpal\u0105.<\/p>\n

Infografikas, padedantis suprasti eksperiment\u0105<\/strong><\/h2>\n

 <\/p>\n

\"Per\u017ei\u016br\u0117ti_77833<\/a><\/p>\n

 <\/p>\n

Infografik\u0105 suk\u016briau naudodamasis Mind the Graph. Jei norite naudoti patrauklias mokslines iliustracijas, kad savo tyrimais pasiektum\u0117te daugiau \u017emoni\u0173, taip pat galite naudoti \"mind the Graph\"!<\/p>\n

\"Per\u017ei\u016bra_250\"<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Jeilio universiteto mokslininkai kelias valandas po mirties kiauli\u0173 smegenis laik\u0117 gyvas u\u017e k\u016bno rib\u0173. Straipsnyje \"Smegen\u0173 kraujotakos ir l\u0105steli\u0173 funkcij\u0173 atk\u016brimas pra\u0117jus kelioms valandoms po mirties\" paai\u0161kinamas eksperimentas, atliktas naudojant kiauli\u0173 smegenis, kuris gali pad\u0117ti i\u0161ry\u0161kinti smegen\u0173 pa\u017eeidim\u0173 tyrimus. \u017durnalas \"Nature\" \u0161\u012f straipsn\u012f paskelb\u0117 baland\u017eio 17 d. \"Did\u017ei\u0105j\u0105 \u017emonijos istorijos dal\u012f mirtis buvo labai paprasta\", - [...]<\/p>","protected":false},"author":11,"featured_media":8721,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[54,288,287,286,282,554,71,964,775,70],"yoast_head":"\nBrain damage: an infographic to understand the new Nature paper - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Scientists from Yale University kept pig brains alive for hours after death. 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