{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/alzheimerio-liga\/","title":{"rendered":"Alzheimerio liga: Alzheimerio liga: mokslinis infografikas"},"content":{"rendered":"

Visada d\u017eiaugiam\u0117s, kai matome nuostabius savo naudotoj\u0173 darbus.\u00a0A\u0161 jau ra\u0161iau<\/a> apie dr. Alessandros Martini, dr.\u00a0Stefania Forner<\/a>\u00a0ir j\u0173 kolegos. Jie yra Kalifornijos universiteto podoktorant\u016bros tyr\u0117jai ir r\u016bpinasi graf\u0173 vartotojais. Prie\u0161 kelis m\u0117nesius parod\u017eiau infografikos<\/a>\u00a0Dr. Stefania Forner pareng\u0117 ap\u017evalgin\u012f straipsn\u012f, paskelbt\u0105 \u017eurnale \"Trends in Neurosciences\", pavadinimu \"Synaptic impairment in Alzheimer's Disease\": A disregulated symphony.<\/p>\n

\u0160iandien noriu pakalb\u0117ti apie j\u0173 nauj\u0105 ap\u017evalgin\u012f straipsn\u012f, pavadint\u0105 I\u0161 praeities \u012f ateit\u012f: ko gyv\u016bn\u0173 modeliai mus i\u0161mok\u0117 apie Alzheimerio lig\u0105.<\/a><\/p>\n

Alzheimerio liga (AL) yra neurodegeneracinis sutrikimas, d\u0117l kurio sutrinka pa\u017einimo funkcijos ir prarandama atmintis. Norint pagerinti pacient\u0173 gyvenimo kokyb\u0119 ir rasti veiksming\u0105 gydym\u0105, svarbu suprasti ligos mechanizm\u0105. \u0160iandien, nepaisant did\u017eiuli\u0173 akademin\u0117s bendruomen\u0117s ir farmacijos pramon\u0117s pastang\u0173, veiksming\u0173 gydymo b\u016bd\u0173 n\u0117ra. Alzheimerio liga yra \u0161e\u0161toji pagrindin\u0117 mirties prie\u017eastis JAV ir ja serga 35 mln. \u017emoni\u0173 visame pasaulyje.<\/p>\n

Alzheimerio ligos infografika<\/h2>\n

 <\/p>\n

Dauguma AD sergan\u010di\u0173 pacient\u0173 yra vyresnio am\u017eiaus \u017emon\u0117s, kurie paprastai serga \u012fvairiomis gretutin\u0117mis ligomis. Diabetas, osteoporoz\u0117, inkst\u0173 ligos, nutukimas, hipertenzija ir hipercholeterolemija\/dislipidemija, insultas ir priepuoliai yra pagrindin\u0117s gretutin\u0117s ligos, turin\u010dios \u012ftakos Alzheimerio ligos atsiradimui ir progresavimui, ir dar labiau apsunkinan\u010dios ligos patogenez\u0119.<\/p>\n

\"infografika
Infografikas, rodantis Alzheimerio ligos (AD) gretutines ligas. Praeitis \u012f ateit\u012f: Gyv\u016bn\u0173 modeliai mus i\u0161mok\u0117 apie Alzheimerio lig\u0105.<\/figcaption><\/figure>\n

 <\/p>\n

\n

Nepaisant intensyvi\u0173 pastar\u0173j\u0173 keli\u0173 de\u0161imtme\u010di\u0173 mokslini\u0173 tyrim\u0173, sporadin\u0117s Alzheimerio ligos (sAD), kuri yra labiausiai paplitusi ligos forma, etiologijos mechanizmai vis dar ne\u017einomi. Bent i\u0161 dalies taip yra d\u0117l to, kad dauguma sAD sergan\u010di\u0173 pacient\u0173 yra vyresnio am\u017eiaus \u017emon\u0117s, kurie da\u017eniausiai serga \u012fvairiomis gretutin\u0117mis ligomis (pvz., insultu, stresu, diabetu, traukuliais, osteoporoze ir inkst\u0173 ligomis).<\/em><\/p>\n<\/blockquote>\n

Kitame infografike parodytas tau ir beta amiloido oligomer\u0173 toksi\u0161kumo sinaps\u0117ms susidarymas ir mechanizmai.<\/p>\n

 <\/p>\n

\"infografico
Praeitis \u012f ateit\u012f: Gyv\u016bn\u0173 modeliai mus i\u0161mok\u0117 apie Alzheimerio lig\u0105<\/figcaption><\/figure>\n

 <\/p>\n

\n

Tauopatij\u0173 metu suma\u017e\u0117ja dendritini\u0173 spygli\u0173 skai\u010dius. Tau nepatenka \u012f neurono branduol\u012f, tod\u0117l pa\u017eeid\u017eiama DNR. Suma\u017e\u0117ja mitochondrij\u0173, taip pat presinapsini\u0173 p\u016bsleli\u0173 skai\u010dius, tod\u0117l prarandamos sinaps\u0117s. Toks praradimas taip pat atsiranda d\u0117l tau patekimo \u012f dendritus ir postsinapsines sritis. Tau taip pat agreguojasi ekstral\u0105steliniu b\u016bdu, tod\u0117l j\u012f gali pagauti kiti neuronai.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

Ji taip pat suk\u016br\u0117 infografik\u0105, kuriame parodyti u\u017edegiminiai mechanizmai, susij\u0119 su Alzheimerio liga (AD).<\/p>\n

 <\/p>\n

\"infografico<\/p>\n

 <\/p>\n

\n

Pastaruosius kelerius metus ypa\u010d dom\u0117jom\u0117s, kaip u\u017edegimas veikia beta amiloido ir tau patologij\u0105. Pagyven\u0119 \u017emon\u0117s yra jautr\u016bs virusin\u0117ms ir bakterin\u0117ms infekcijoms, o \u0161ie mikrobiniai veiksniai gali sustiprinti esam\u0105 u\u017edegimin\u0119 b\u016bkl\u0119 smegenyse ir pagreitinti pa\u017einimo funkcij\u0173 blog\u0117jim\u0105.<\/em><\/p>\n<\/blockquote>\n

Pagyrimai Dr. Stefania Forner u\u017e puik\u0173 darb\u0105!<\/p>\n

Jei esate mokslininkas ir norite kurti gra\u017eius skai\u010dius savo darbui, galite tapti \"mind the graph\" naudotoju jau dabar.<\/p>\n

\"untitled-creation63724<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Visada d\u017eiaugiam\u0117s, kai matome nuostabius savo naudotoj\u0173 darbus. Jau ra\u0161iau apie daktar\u0117s Alessandros Martini, daktar\u0117s Stefanijos Forner ir j\u0173 koleg\u0173 tyrimus. Jie yra Kalifornijos universiteto podoktorant\u016bros tyr\u0117jai ir galvoja apie graf\u0173 naudotojus. Prie\u0161 kelis m\u0117nesius rod\u017eiau infografik\u0105, Dr. Stefania Forner sukurt\u0105 ap\u017evalginiam straipsniui, paskelbtam \u017eurnale \"Trends [...]<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/lt\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"lt_LT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - 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