{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/autofagija-gauna-nobelio-premija-medicina\/","title":{"rendered":"Nobelio medicinos premija u\u017e autofagij\u0105"},"content":{"rendered":"

Autofagijos procesas yra susij\u0119s su keliomis ligomis, pavyzd\u017eiui, v\u0117\u017eiu ir neurologin\u0117mis ligomis. Jis veikia kaip vidin\u0117 organizmo perdirbimo programa. Ta\u010diau sutrik\u0119s autofagijos veikimas siejamas su Parkinsono liga, diabetu, v\u0117\u017eiu ir kitais su am\u017eiumi susijusiais sutrikimais.<\/p>\n

Po \u0161ios nedidel\u0117s \u012f\u017eangos apie autofagijos proceso svarb\u0105 nenuostabu, kad nauji atradimai \u0161ioje srityje gali lemti Nobelio premijos skyrim\u0105. I\u0161 ties\u0173, pra\u0117jus\u012f pirmadien\u012f mokslinink\u0117 Yoshino Ohsumi laim\u0117jo Nobelio medicinos premija<\/a> nustatant pirmuosius autofagijai b\u016btinus genus.<\/p>\n

\"Nesijau\u010diu patogiai var\u017eydamasis su daugeliu \u017emoni\u0173, tod\u0117l man maloniau daryti tai, ko niekas kitas nedaro. Tam tikra prasme tai ir yra mokslas, o d\u017eiaugsmas k\u0105 nors atrasti mane \u012fkvepia.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Kaip tai padar\u0117 Ohsumi?<\/h3>\n

Savo laboratorijoje Ohsumi suk\u016br\u0117 mieli\u0173 padermes, kurios badavimo metu kaup\u0117 autofagosomas. \u0160is kaupimasis gal\u0117jo \u012fvykti tik tuo atveju, jei autofagijai b\u016btini genai buvo neaktyv\u016bs. Taigi Ohsumi \u0117m\u0117 manipuliuoti l\u0105stel\u0117mis, kad b\u016bt\u0173 kelios gen\u0173 mutacijos, ir jam pavyko sukelti autofagij\u0105.<\/p>\n

\"Nobelio<\/a><\/p>\n

Autofagija jau seniai<\/h3>\n

Nors apie autofagij\u0105 \u017einoma jau 50 met\u0173, \u0161io proceso svarba pripa\u017einta tik 1990-aisiais, atlikus Ohsumi tyrimus.
\nU\u017e savo darb\u0105 Ohsumi jau peln\u0117 kelet\u0105 gerb\u0117j\u0173:<\/p>\n

\"Nobelio<\/a><\/p>\n

\n

\"Labai d\u017eiaugiuosi, kad jis \u0161iemet gavo Nobelio premij\u0105, ji labai pelnyta. Jo laboratorija daugiausia dirba su miel\u0117mis. Jie atliko pirminius atrankinius tyrimus, kurie leido atrasti pagrindinius genus, dalyvaujan\u010dius autofagijoje. Daugyb\u0117 kit\u0173 laboratorij\u0173 tiesiogiai ar netiesiogiai pasinaudojo jo atradimais, kad i\u0161siai\u0161kint\u0173, kod\u0117l tai svarbu sergant ligomis.\"<\/p>\n

David Rubinsztein<\/a> - Kembrid\u017eo medicinos tyrim\u0173 instituto direktoriaus pavaduotojas<\/p>\n<\/blockquote>\n

\"Nobelio<\/a><\/p>\n

\n

\"Manau, labai svarbu, kad \u0161i mokslo sritis b\u016bt\u0173 pripa\u017einta. Svarbus principas - ie\u0161koti bendr\u0173 lig\u0173 mechanizm\u0173. Tai atveria kelius gydyti \u0161iuos sutrikimus, kurie skiriasi nuo labiau \u012fprast\u0173, konkre\u010dioms ligoms b\u016bding\u0173 metod\u0173.\"<\/p>\n

Giovanna Mallucci<\/a> - Kembrid\u017eo universiteto klinikin\u0117s neurologijos profesorius.<\/p>\n<\/blockquote>\n

\"Nobelio<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Autofagijos procesas yra susij\u0119s su keliomis ligomis, pavyzd\u017eiui, v\u0117\u017eiu ir neurologin\u0117mis ligomis. Jis veikia kaip vidin\u0117 organizmo perdirbimo programa. Ta\u010diau sutrik\u0119s autofagijos veikimas siejamas su Parkinsono liga, diabetu, v\u0117\u017eiu ir kitais su am\u017eiumi susijusiais sutrikimais. Po \u0161ios nedidel\u0117s \u012f\u017eangos apie autofagijos proceso svarb\u0105 nenuostabu, kad nauji atradimai [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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