{"id":5346,"date":"2016-03-03T13:41:11","date_gmt":"2016-03-03T16:41:11","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=5346"},"modified":"2022-10-18T08:29:24","modified_gmt":"2022-10-18T11:29:24","slug":"zika-virus-graphical-abstract","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/zikos-viruso-grafinis-abstraktas\/","title":{"rendered":"Zikos viruso grafin\u0117 santrauka apie mikrocefalij\u0105"},"content":{"rendered":"

Suprasti Zikos viruso grafin\u0119 santrauk\u0105: kaip jis ma\u017eina smegen\u0173 dyd\u012f<\/h3>\n

\u0160iandien atliktas mokslinis tyrimas pateik\u0117 \u012fdomi\u0173 \u012frodym\u0173 apie Zikos viruso vaidmen\u012f nervini\u0173 audini\u0173 apsigimim\u0173 atsiradimui. Ak, taip, prie\u0161 jums klausiant, \u017emogaus nervinis audinys.<\/p>\n

Tai eleganti\u0161kai padar\u0117 daktaro Stevenso Reheno, tarptautiniu mastu \u017einomo kamienini\u0173 l\u0105steli\u0173 tyrim\u0173, o pastaruoju metu ir l\u0105steli\u0173 perprogramavimo srityje, grup\u0117.<\/p>\n

Toliau pateiktame paveiksl\u0117lyje apibendrintos i\u0161vados popierius<\/a>, bet pabandysiu trumpai paai\u0161kinti.<\/p>\n

 <\/p>\n

\"dienora\u0161tis<\/p>\n

\u0160is \u012f\u017evalgus Zikos viruso grafinis abstraktas buvo atliktas naudojant \"Mind the graph\". Argi ne \u0161aunu?<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

Kaip matote paveiksl\u0117lyje, \u0161iame tyrime buvo taikomi trys skirtingi metodai. Visi jie patvirtina, kad Zikos virusas daro tiesiogin\u0119 \u012ftak\u0105 tam, kaip smegen\u0173 l\u0105stel\u0117s evoliucionuoja, kad suformuot\u0173 tinkam\u0105 neuronin\u012f audin\u012f, dar vadinam\u0105 \"ink\u0161tir\u0173 smegen\u0173 malformacija\".\"Zikos<\/a>Mikrocefalija yra tik vienas i\u0161 smegen\u0173 apsigimim\u0173. Straipsnyje teigiama, kad tai yra dar svarbesnis dalykas.<\/p>\n

Jie rodo, kaip Zikos virusas:<\/p>\n

    \n
  1. Skatina l\u0105steli\u0173 mirt\u012f<\/li>\n
  2. Sukelia morfologinius poky\u010dius (neurosferose)<\/li>\n
  3. Suma\u017eina smegen\u0173 organoid\u0173 (mini smegen\u0173) augim\u0105 ir dyd\u012f<\/li>\n<\/ol>\n

    Tai yra visi b\u016bdai, kaip Zikos virusas gali paveikti neurogenez\u0119 \u017emogaus smegen\u0173 vystymosi metu ir sukelti toliau matom\u0105 fenotip\u0105.<\/p>\n

    \"Zikos<\/a><\/p>\n

    <\/h3>\n

    Kod\u0117l tai nebuvo padaryta anks\u010diau?<\/h3>\n

    Naujovi\u0161kas metodas buvo indukuotos pliuripotencijos kamienini\u0173 l\u0105steli\u0173 (iPS l\u0105steli\u0173) panaudojimas, kad b\u016bt\u0173 galima tirti virus\u0173 infekcij\u0105 \u017emogaus l\u0105stel\u0117se.<\/p>\n

    \u0160io proceso metu i\u0161 \u017emogaus paimtos somatin\u0117s l\u0105stel\u0117s perprogramuojamos \u012f pradin\u0119 pluripotentin\u0117s l\u0105stel\u0117s b\u016bsen\u0105 ir v\u0117liau gali b\u016bti diferencijuojamos \u012f \u012fvairias l\u0105steles, audinius, o pastaruoju metu ir organus. Tai yra \"\u017emogaus audini\u0173 in\u017einerijos\" prad\u017eia.<\/p>\n

    Tyrime autoriai ne tik naudojo iPS l\u0105steles, bet ir suk\u016br\u0117 smegen\u0173 organoidai<\/a>, dar vadinamomis \"ma\u017eosiomis smegenimis\", siekiant i\u0161siai\u0161kinti, kaip Zikos virusas veikia \u0161io neuroninio audinio formavim\u0105si.<\/p>\n

    Tokios l\u0105steli\u0173 kult\u016bros laikomos trimat\u0117mis (3D) strukt\u016bromis ir suteikia daugiau informacijos apie organ\u0173 architekt\u016br\u0105. Tai yra organoido metai pagal Ekonomistas<\/a>. Taikydami \u0161\u012f naujovi\u0161k\u0105 metod\u0105 mokslininkai gal\u0117jo suprasti, kaip zikos virusas veikia \u017emogaus smegen\u0173 l\u0105steles, ma\u017eindamas j\u0173 gyvybingum\u0105 ir augim\u0105 neurosfer\u0173 ir smegen\u0173 organoid\u0173 pavidalu.<\/p>\n

    Svetain\u0117 popierius<\/a> yra i\u0161 anksto i\u0161spausdintas novatori\u0161kame \u017eurnale \"PeerJ\". Proceso metu netgi galite pateikti komentar\u0173 ir pad\u0117ti autoriams j\u012f patobulinti. Toliau galite pamatyti santrauk\u0105, o vis\u0105 prieig\u0105 prie jos rasite paspaud\u0119 \u010dia<\/a>.<\/p>\n

    \"Zikos<\/a><\/p>\n

    Pastaba: Pra\u0117jus dviem m\u0117nesiams po 2016 m. kovo m\u0117n., kai \"PeerJ\" buvo i\u0161spausdintas i\u0161ankstinis atspaudas, buvo i\u0161leistas galutinis straipsnis ir, m\u016bs\u0173 nuostabai, jis buvo paskelbta \"Science <\/a>\u017durnalas, vienas presti\u017ei\u0161kiausi\u0173 mokslini\u0173 \u017eurnal\u0173 planetoje.<\/p>\n

    -> Skaitykite vis\u0105 Garcez ir kt. straipsn\u012f \u017eurnale \"Science\" <-<\/a><\/p>\n

    \"Zikos<\/a><\/p>\n

    Tegul apie tai su\u017eino daugiau \u017emoni\u0173, kurie dalijasi \u0161iuo prane\u0161imu. Tai yra pasaulin\u0117s visuomen\u0117s sveikatos klausimas, kaip jau teig\u0117 Pasaulio sveikatos organizacija<\/a>\u00a0(PSO).<\/p>\n

    \n

     <\/p>\n

    \u017dinokite, k\u0105 PSO pataria d\u0117l Zikos viruso<\/a>\u00a0perdavim\u0105 ir infekcij\u0105:<\/p>\n

    \n

    Transmisija<\/h3>\n

    Zikos virusas \u017emon\u0117ms pirmiausia perduodamas per \u012fkandimus nuo Aedes<\/i> uodai, kurie da\u017enai gyvena aplink pastatus miestuose ir paprastai b\u016bna aktyv\u016bs \u0161viesiu paros metu (did\u017eiausias \u012fkandim\u0173 aktyvumas b\u016bna ankstyv\u0105 ryt\u0105 ir v\u0117lyv\u0105 popiet\u0119).<\/p>\n

    Kai kurie duomenys rodo, kad Zikos virusas taip pat gali b\u016bti perduodamas \u017emon\u0117ms perpilant krauj\u0105, perinataliniu ir lytiniu b\u016bdu. Ta\u010diau \u0161ie b\u016bdai yra labai reti.<\/p>\n

    Inkubacinis laikotarpis paprastai trunka nuo 2 iki 7 dien\u0173.<\/p>\n

    Po\u017eymiai ir simptomai<\/h3>\n

    Zikos viruso infekcijai b\u016bdingas nedidelis kar\u0161\u010diavimas (ma\u017eiau nei 38,5 \u00b0C), kur\u012f da\u017enai lydi makulopapulinis b\u0117rimas. Kiti da\u017eni simptomai: raumen\u0173 skausmas, s\u0105nari\u0173 skausmas su galimu patinimu (ypa\u010d smulki\u0173j\u0173 rank\u0173 ir koj\u0173 s\u0105nari\u0173), galvos skausmas, skausmas u\u017e aki\u0173 ir konjunktyvitas. Kadangi simptomai da\u017enai b\u016bna lengvi, infekcija gali b\u016bti neatpa\u017e\u012fstama arba klaidingai diagnozuojama kaip deng\u0117.<\/p>\n

    Tikimasi, kad Zikos virusas, kaip ir kiti flavivirusai, pavyzd\u017eiui, Deng\u0117 virusas ir Vakar\u0173 Nilo virusas, labai da\u017enai u\u017esikre\u010dia besimptome infekcija. Dauguma \u017emoni\u0173 visi\u0161kai pasveiksta be sunki\u0173 komplikacij\u0173, o hospitalizacijos atvej\u0173 skai\u010dius yra nedidelis. Iki \u0161iol nebuvo u\u017eregistruota n\u0117 vieno mirties atvejo, susijusio su Zikos virusu.<\/p><\/blockquote>\n

     <\/p>\n

    Atnaujinta 2016 m. gegu\u017e\u0117s 3 d.<\/p>","protected":false},"excerpt":{"rendered":"

    Suprasti Zikos viruso grafin\u0119 santrauk\u0105: kaip jis ma\u017eina smegen\u0173 dyd\u012f \u0160iandien atliktas mokslinis tyrimas pateik\u0117 \u012fdomi\u0173 \u012frodym\u0173 apie Zikos viruso vaidmen\u012f nervini\u0173 audini\u0173 formavimosi ydoms. Ak, taip, prie\u0161 jums klausiant, \u017emogaus nervinis audinys. Tai eleganti\u0161kai padar\u0117 daktaro Stevenso Reheno (Stevens Rehen), tarptautiniu mastu \u017einomo mokslininko, tyrin\u0117jusio [...]<\/p>","protected":false},"author":4,"featured_media":7136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[956],"tags":[96,201,200,203,202,205,554,71,250,204,199],"yoast_head":"\nZika virus graphical abstract on microcephaly - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This insightful Zika virus graphical abstract was done with Mind the graph. 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