{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/success-case-nuclear-receptors-in-liver-fibrosis\/","title":{"rendered":"Kepen\u0173 fibroz\u0117s branduoliniai receptoriai Knygos ap\u017evalga"},"content":{"rendered":"

\u0160iuo atveju autorius naudojo Mind the Graph, kad surinkt\u0173 duomenis i\u0161 \u012fvairi\u0173 \u0161altini\u0173 vienoje vietoje. Be geriausi\u0173 moksli\u0161kai tiksli\u0173 iliustracij\u0173, m\u016bs\u0173 darbo erdv\u0117 turi draugi\u0161k\u0105 s\u0105saj\u0105 ir j\u0105 labai lengva naudoti.<\/p>\n\n\n\n

Patikrinkite vis\u0105 originalus straipsnis<\/a>. <\/p>\n\n\n\n

Branduolini\u0173 receptori\u0173 vaidmuo kepen\u0173 fibrozei<\/strong><\/h2>\n\n\n\n

Philipp K\u00f6nigshofer ir kiti (2021) prane\u0161a, kad branduoliniai receptoriai yra ligand\u0173 aktyvuojami transkripcijos veiksniai, reguliuojantys \u012fvairi\u0173 pagrindini\u0173 molekulini\u0173 signal\u0173, susijusi\u0173 su kepen\u0173 fibroze, gen\u0173 rai\u0161k\u0105. <\/p>\n\n\n\n

Pagrindinis kepen\u0173 fibrogenez\u0117s l\u0105stelinis veiksnys yra aktyvuotos kepen\u0173 \u017evaig\u017edin\u0117s l\u0105stel\u0117s. Skirtingi branduoliniai receptoriai reguliuoja u\u017edegim\u0105 ir fibrogenizm\u0105 skatinan\u010di\u0173 citokin\u0173 rai\u0161k\u0105 kepenyse.<\/p>\n\n\n\n

Grafin\u0117s santraukos, sukurtos naudojant Mind the Graph<\/strong> \u0161iame straipsnyje<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Pagaminta i\u0161 Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n
<\/div>\n\n\n\n

Pirmajame paveiksl\u0117lyje pateikta branduolini\u0173 receptori\u0173 ap\u017evalga ir klasifikacija pagal sub\u0161eimas.<\/p>\n\n\n\n

<\/div>\n\n\n
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Pagaminta i\u0161 Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Vir\u0161uje matome \u012fvairi\u0173 tip\u0173 branduolini\u0173 receptori\u0173 efektori\u0173 funkcijas.<\/p>\n\n\n\n

<\/div>\n\n\n
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Pagaminta i\u0161 Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Tre\u010diajame paveiksl\u0117lyje ap\u017evelgiamas NR moduliacij\u0173, kaip galim\u0173 terapini\u0173 metod\u0173 kepen\u0173 ligoms gydyti, poveikis. <\/p>\n\n\n\n

Rodykl\u0117s rodo numanom\u0105 teigiam\u0105 poveik\u012f kepen\u0173 ligoms. \u012f vir\u0161\u0173 - (tamsiai \u017ealia)<\/strong><\/span> arba \u017eemyn (\u0161viesiai \u017ealia)<\/span><\/strong> konkre\u010di\u0173 mechanizm\u0173, kurie, kaip buvo prane\u0161ta, palaiko kepen\u0173 fibroz\u0117s regresij\u0105 arba ma\u017eina kepen\u0173 fibroz\u0119, reguliavimas. <\/p>\n\n\n\n

Oran\u017ein\u0117s rodykl\u0117s<\/mark><\/strong> nurodo NR moduliacijos poveik\u012f ir mechanizmus, kurie yra prie\u0161taringi arba dar nepakankamai \u012fvertinti.<\/p>\n\n\n\n

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Pagaminta i\u0161 Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Paskutiniame paveiksl\u0117lyje pavaizduotas molekulinis NR moduliatori\u0173, kaip galimo kepen\u0173 fibroz\u0117s gydymo b\u016bdo, poveikis, kuris, kaip prane\u0161ama, daugiausia pasirei\u0161kia HSC.<\/p>\n\n\n\n

K\u00f6nigshofer ir kolegos teigia, kad tolesni su branduoliniais receptoriais susijusi\u0173 signal\u0173 tyrimai gali pad\u0117ti klini\u0161kai kurti veiksmingus antifibrozinius gydymo b\u016bdus kepen\u0173 ligomis sergantiems pacientams.<\/p>\n\n\n\n

Dokument\u0173 poveikis ir na\u0161umas<\/strong><\/h2>\n\n\n\n

Pasirink\u0119 vieneri\u0173 met\u0173 rodikli\u0173 palyginimo variant\u0105 su kitais straipsniais ir (arba) ap\u017evalgomis, kurie taip pat buvo paskelbti tais pa\u010diais kalendoriniais metais tame \u017eurnale, galime pasteb\u0117ti, kad \u0161is straipsnis buvo cituojamas da\u017eniau nei 57% i\u0161 j\u0173<\/strong>.<\/p>\n\n\n

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\u0160altinis PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Pasinaudokite infografikos galia ir savo straipsniui pagyvinti. I\u0161bandykite Mind the Graph!<\/p>\n\n\n\n

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I\u0161bandykite Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\u0160iame straipsnyje pateikiamos mokslin\u0117s iliustracijos, sukurtos naudojant Mind the Graph, vaizduojan\u010dios branduolinius receptorius kepen\u0173 fibroz\u0117je.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nNuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/lt\/success-case-nuclear-receptors-in-liver-fibrosis\/\" \/>\n<meta property=\"og:locale\" content=\"lt_LT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/lt\/success-case-nuclear-receptors-in-liver-fibrosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-16T22:40:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nuclear receptors in liver fibrosis Paper Review - 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