{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/sekmes-atvejis-zika-virusas-replikuojasi-suaugusio-zmogaus-smegenu-taske-ir-pazeidzia-sinapses-ir-atminti-pelese\/","title":{"rendered":"Zikos virusas replikuojasi suaugusio \u017emogaus smegen\u0173 audinyje ir pa\u017eeid\u017eia peli\u0173 sinapses bei atmint\u012f Paper Review"},"content":{"rendered":"

ZIKV yra pavojingas virusas, siaubiantis pasaul\u012f. Tod\u0117l \u0161iuo atveju autorius tiria jo replikacij\u0105 suaugusio \u017emogaus smegenyse.<\/p>\n\n\n\n

Zikos virusas (ZIKV) u\u017ekre\u010dia suaugusi\u0173 peli\u0173 smegen\u0173 audin\u012f ir sukelia atminties sutrikimus<\/strong><\/h2>\n\n\n\n

Farmacijos mokyklos grup\u0117, vadovaujama Claudia Figueiredo (2019 m.), tyr\u0117, kaip zikos virusas replikuojasi suaugusio \u017emogaus smegen\u0173 audinyje ir pa\u017eeid\u017eia peli\u0173 sinapses bei atmint\u012f. Zikos virusas yra Flaviviridae \u0161eimai priklausantis arbovirusas, atsakingas u\u017e neseniai kilus\u012f didel\u012f protr\u016bk\u012f Lotyn\u0173 Amerikoje. <\/p>\n\n\n\n

Suaugusi\u0173 pacient\u0173 smegenyse ir smegen\u0173 skystyje rasta ZIKV. NS2B imunoreaktyvumas kolokavo su NeuN imunoreaktyviomis l\u0105stel\u0117mis, bet ne su GFAP ar F4\/80, o tai rodo, kad ZikV brandaus \u017emogaus audiniuose yra nukreiptas \u012f neuronus. Suaugusi\u0173 imunokompetentini\u0173 peli\u0173, u\u017esikr\u0117tusi\u0173 ZikV intracerebroventrikuline infuzija, priekin\u0117je \u017eiev\u0117je ir hipokampe aptinkamas didelis ZikV RNR kiekis, o brand\u016bs neuronai yra pagrindinis u\u017esikr\u0117tusi\u0173 l\u0105steli\u0173 tipas. <\/p>\n\n\n\n

Nustatytas padid\u0117j\u0119s TNF-\u03b1 kiekis smegenyse, intensyvi mikroglioz\u0117, padid\u0117jusi komplemento sistemos baltym\u0173 (C1q ir C3) rai\u0161ka ir hipokampo sinapsi\u0173 pa\u017eeidimas.<\/p>\n\n\n\n

Tyrime dalyvavo 9 vienodi kvadratai.<\/strong><\/p>\n\n\n\n

Patikrinkite originalus straipsnis \u010dia<\/a>.<\/p>\n\n\n\n

Grafin\u0117s santraukos, sukurtos naudojant Mind the Graph<\/strong><\/h2>\n\n\n\n
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Pagaminta i\u0161 Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Pirmajame paveiksl\u0117lyje pavaizduotas atvejis, kai \u017emogaus momenin\u0117s skilties \u017eiev\u0117s audinio fragmentai buvo supjaustyti 400 \u00b5m grie\u017ein\u0117liais ir laikomi kult\u016broje 4 dienas prie\u0161 inkubuojant su ZIKV (107 PFU) arba imitacine terpe 1 val., po to i\u0161plaunant. <\/p>\n\n\n\n

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Pagaminta i\u0161 Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Antrame paveiksl\u0117lyje matyti, kad suaugusioms pel\u0117ms \u012f \u0161onin\u012f smegen\u0173 skilvel\u012f buvo infuzuota 105 PFU ZIKV, UV inaktyvuoto ZIKV arba pa\u0161aipos terp\u0117.<\/p>\n\n\n\n

Atrodo, kad i\u0161vados patvirtina tai, kas anks\u010diau buvo \u017einoma \u0161iuo klausimu: \"ZIKV veikia su atmintimi susijusias smegen\u0173 sritis nepriklausomai nuo to, ar u\u017esikr\u0117timo kelias yra centrinis, ar periferinis. Virusas aptiktas suaugusi\u0173 pacient\u0173, kuriems pasirei\u0161k\u0117 neurologini\u0173 komplikacij\u0173, smegen\u0173 skystyje\", - teig\u0117 Figueiredo.<\/p>\n\n\n\n

Jie teigia, kad ateityje reik\u0117t\u0173 atlikti tyrimus, kuri\u0173 tikslas - i\u0161tirti ilgalaik\u012f ZIKV infekcijos poveik\u012f neurodegeneracijai. Nusta\u010dius b\u016bdus, kaip u\u017ekirsti keli\u0105 signal\u0173 anomalijoms, lemian\u010dioms smegen\u0173 funkcijos sutrikimus, b\u016bt\u0173 galima parengti intervencijos strategijas, kurios pad\u0117t\u0173 atitolinti pagrindini\u0173 neurologini\u0173 lig\u0173 vystym\u0105si arba u\u017ekirsti joms keli\u0105.<\/p>\n\n\n\n

Dokument\u0173 poveikis ir na\u0161umas<\/strong><\/h2>\n\n\n\n

Galime analizuoti su Altmetric<\/a> duomen\u0173, kad \u0161io dokumento d\u0117mesio internete balas yra didesnis nei 95%<\/strong><\/strong> vis\u0173 kit\u0173 pana\u0161aus am\u017eiaus straipsni\u0173 gamtoje<\/strong> \u017durnalai.<\/strong><\/p>\n\n\n\n

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\u0160altinis Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Pasinaudokite infografikos galia ir savo straipsniui pagyvinti! Prad\u0117kite kurti Mind the Graph.<\/p>\n\n\n\n

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I\u0161bandykite Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Tyrime kalbama apie ZIKV suaugusio \u017emogaus smegenyse - pavojing\u0105 virus\u0105, kuris niokoja pasaul\u012f. Procese naudojamos Mind the Graph iliustracijos.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/lt\/sekmes-atvejis-zika-virusas-replikuojasi-suaugusio-zmogaus-smegenu-taske-ir-pazeidzia-sinapses-ir-atminti-pelese\/\" \/>\n<meta property=\"og:locale\" content=\"lt_LT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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