{"id":13008,"date":"2021-06-21T18:09:00","date_gmt":"2021-06-21T21:09:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=13008"},"modified":"2023-01-05T14:38:06","modified_gmt":"2023-01-05T17:38:06","slug":"napping-time-genetics","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/snaudimo-laiko-genetika\/","title":{"rendered":"Mieguistumo laiko genetika: Kaip snaudimas gali tur\u0117ti \u012ftakos genetiniams poky\u010diams"},"content":{"rendered":"

Dienos metu snaudimas yra daugumos \u017emoni\u0173 kaltas malonumas.<\/p>\n\n\n

\n
\"Garfildas<\/a><\/figure><\/div>\n\n\n

Da\u017eniausiai tai b\u016bna \u012fprotis, \u012fsi\u0161aknij\u0119s kasdien\u0117je rutinoje. Tai labai b\u016bdinga daugeliui r\u016b\u0161i\u0173 - nuo musi\u0173 iki \u017einduoli\u0173.<\/p>\n\n\n\n

Mieguistumas taip pat yra susij\u0119s su budrumo didinimu, o tai labai svarbu dirbantiems v\u0117lai vakare arba tiems, kuriems paprastai tr\u016bksta miego.<\/p>\n\n\n\n

Taip pat teigiama, kad jis padeda pagerinti veiklos rezultatus, atmint\u012f ir suma\u017einti stres\u0105. <\/p>\n\n\n\n

Ta\u010diau, be \u0161ios naudos, ilgalaik\u0117s snaudimo pasekm\u0117s gali b\u016bti l\u0117tin\u0117s ir neigiamai paveikti asmens gerov\u0119.<\/p>\n\n\n\n

Nors tai prie\u0161taringa tema ir prie\u017eastis gali b\u016bti daugyb\u0117 su sauskeln\u0117mis susijusi\u0173 veiksni\u0173, pavyzd\u017eiui, netinkamas miego ciklas, netinkama mityba ar prasta sveikata.<\/p>\n\n\n\n

Ar miego laikas dienos metu yra j\u016bs\u0173 laiminga valanda? Mokslininkai teigia kitaip. <\/strong><\/p>\n\n\n\n

Grup\u0117 tyr\u0117j\u0173 analizavo miego poveik\u012f pagal genetinius poky\u010dius.<\/p>\n\n\n\n

J\u0173 tyrimo metu buvo siekiama i\u0161siai\u0161kinti skirting\u0173 asmen\u0173 genetinius skirtumus, susijusius su miego trukme ir pageidavimais.<\/p>\n\n\n\n

\u0160iuo metu atlikus genomo asociacijos tyrim\u0105 aptikta apie septynis genetinius lokusus, kurie atitinka miego laik\u0105 dienos metu.<\/p>\n\n\n\n

Tyr\u0117jai naudojo Jungtin\u0117s Karalyst\u0117s Biobanko europie\u010di\u0173 kilm\u0117s dalyvius (n=452 633), i\u0161 kuri\u0173 ma\u017edaug 38,2% dalyvi\u0173 kartais snaud\u0117, o 5,3% dalyvi\u0173 visada snaud\u0117 dienos metu.<\/p>\n\n\n\n

Beveik visada snaud\u0117 vyresnio am\u017eiaus vyrai, turintys didel\u012f KMI arba k\u016bno mas\u0117s indeks\u0105, kuriems buvo diagnozuoti miego sutrikimai, r\u016bkantys arba i\u0161\u0117j\u0119 \u012f pensij\u0105. Jie atliko genomo asociacijos tyrim\u0105 (GWAS) su auk\u0161tos kokyb\u0117s priskiriamais genetiniais variantais, apiman\u010diais apie keturis e\u017eerus dalyvi\u0173. Tai buvo daroma kei\u010diant \u012fvairius anks\u010diau nustatytus veiksnius.<\/p>\n\n\n\n

Jie s\u0117kmingai nustat\u0117 123 genetinius lokusus ir paveldimum\u0105, pagr\u012fst\u0105 vieno nukleotido polimorfizmu, kuris yra ma\u017edaug 11,9%.<\/p>\n\n\n\n

Jie susiaurino savo GWAS su didesnio KMI asmenimis. <\/p>\n\n\n\n

Nustatyta, kad i\u0161 123 lokus\u0173 110 lokus\u0173 buvo sulaikyti genomo mastu.<\/p>\n\n\n\n

Jie taip pat analizavo skirting\u0173 ly\u010di\u0173 miego modeli\u0173 skirtumus, susijusius su X chromosoma. <\/p>\n\n\n\n

Be to, jie taip pat padar\u0117 i\u0161vad\u0105 d\u0117l gen\u0173, kurie buvo atsakingi u\u017e nutukimo hipersomnolencij\u0105: PNOC (prepronociceptinas), <\/em>ir PATJ (trupini\u0173 l\u0105steli\u0173 poliari\u0161kumo komponentas).<\/em><\/p>\n\n\n\n

Be to, FADS1 (riebal\u0173 r\u016bg\u0161\u010di\u0173 desaturaz\u0117s) geno, kuris buvo kolonizuotas, rai\u0161ka parod\u0117 pleiotropin\u012f lipid\u0173 apykaitos poveik\u012f miego modeliui.<\/p>\n\n\n\n

Kitos koreliacijos, susijusios su genomo genetiniais ir tokiais po\u017eymiais kaip glikemijos indeksas, antropometriniai ir kardiometaboliniai rodikliai, i\u0161 kuri\u0173 daugelis koreliacij\u0173 suma\u017e\u0117jo atsi\u017evelgus \u012f KMI. <\/p>\n\n\n\n

Dar daugiau - tai, kad rezultatas, i\u0161analizuotas pagal fenomo masto asociacij\u0105, naudojant dienos miego genomo masto poligenin\u012f genom\u0105, pad\u0117jo nustatyti lig\u0173, susijusi\u0173 su nutukimu, hipertenzija ir, svarbiausia, tam tikromis kardiometabolin\u0117mis ligomis, koreliacij\u0105. <\/p>\n\n\n\n

Apibendrinant galima teigti, kad j\u0173 i\u0161vados atveria akis. Kartais b\u016btent tokie \u012fpro\u010diai sukelia kelet\u0105 nepageidaujam\u0173 komplikacij\u0173 m\u016bs\u0173 organizme. Reikia laikytis sveikos dienotvark\u0117s ir geros gyvensenos praktikos. <\/p>\n\n\n

\n
\"vyras<\/a><\/figure><\/div>\n\n\n

Nor\u0117dami daugiau su\u017einoti apie j\u0173 tyrimus, per\u017ei\u016br\u0117kite toliau pateikt\u0105 nuorod\u0105.<\/p>\n\n\n\n

Dashti, H.S., Daghlas, I., Lane, J.M. ir kt.<\/em> Dienos miego genetiniai veiksniai ir poveikis kardiometabolinei sveikatai. Nat Commun<\/em> 12, 900 (2021). DOI: https:\/\/doi.org\/10.1038\/s41467-020-20585-3<\/a><\/p>\n\n\n\n

Mind the Graph galerijoje rasite daug su genetika susijusi\u0173 iliustracij\u0173. Spustel\u0117kite \u017eemiau esant\u012f paveiksl\u0117l\u012f ir per\u017ei\u016br\u0117kite.<\/p>\n\n\n

\n
\"\"\/<\/a><\/figure><\/div>","protected":false},"excerpt":{"rendered":"

Dienos metu snaudimas yra daugumos \u017emoni\u0173 kaltas malonumas. Da\u017eniausiai tai taip pat b\u016bna \u012fprotis, \u012fsi\u0161aknij\u0119s kasdien\u0117je rutinoje. Tai labai b\u016bdinga daugeliui r\u016b\u0161i\u0173 - nuo musi\u0173 iki \u017einduoli\u0173. Snaudimas taip pat siejamas su budrumo gerinimu, o tai labai svarbu tiems, kurie dirba v\u0117lai vakare, arba tiems, kurie [...]<\/p>","protected":false},"author":18,"featured_media":13012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nDid you know that taking that nap can influence genetic - MTG<\/title>\n<meta name=\"description\" content=\"Is napping time your happy hour? 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